日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Long-term engrafting multilineage hematopoietic cells differentiated from human induced pluripotent stem cells

长期移植由人诱导多能干细胞分化而来的多系造血细胞

Ng, Elizabeth S; Sarila, Gulcan; Li, Jacky Y; Edirisinghe, Hasindu S; Saxena, Ritika; Sun, Shicheng; Bruveris, Freya F; Labonne, Tanya; Sleebs, Nerida; Maytum, Alexander; Yow, Raymond Y; Inguanti, Chantelle; Motazedian, Ali; Calvanese, Vincenzo; Capellera-Garcia, Sandra; Ma, Feiyang; Nim, Hieu T; Ramialison, Mirana; Bonifer, Constanze; Mikkola, Hanna K A; Stanley, Edouard G; Elefanty, Andrew G

Fusion gene depletion eliminates stemness and induces bidirectional differentiation of acute myeloid leukemia

融合基因缺失消除了干性并诱导急性髓系白血病的双向分化。

Derevyanko, Polina K; Swart, Laura E; Mata Casimiro, L Daniel; van Oort, Anita; du Plessis, Manisha; van den Brink, Luca; Ashtiani, Minoo; Zwaan, C Michel; Krippner-Heidenreich, Anja; Bonifer, Constanze; Schiffelers, Raymond; Vormoor, Josef; Kellaway, Sophie G; Heidenreich, Olaf

A heterozygous CEBPA mutation disrupting the bZIP domain in a RUNX1 and SRSF2 mutational background causes MDS disease progression.

在 RUNX1 和 SRSF2 突变背景下,杂合 CEBPA 突变破坏了 bZIP 结构域,导致 MDS 疾病进展

Almaghrabi Ruba, Alyahyawi Yara, Keane Peter, Mian Syed A, Habel Khadidja, Atkinson Amelia, Ward Carl, Bayley Rachel, Sargas Claudia, Menendez Pablo, Murphy George J, Sobahy Turki, Baghdadi Mohammed A, Flemban Arwa F, Kabrah Saeed M, Torres-Ruiz Raul, Papapetrou Eirini P, Akerman Ildem, Raghavan Manoj, Barragan Eva, Bonnet Dominique, Bonifer Constanze, Garcia Paloma

Fusion-specific chromatin profiles mediate transcriptional heterogeneity in MLL-rearranged acute lymphoblastic leukemia

融合特异性染色质谱介导MLL重排急性淋巴细胞白血病中的转录异质性

Lin, Shan; Kotliar, Michael; Vallabh, Sushmitha; Ptasinska, Anetta; Assi, Salam A; Wunderlich, Mark; Bonifer, Constanze; Barski, Artem; Mulloy, James C

Gene regulation in t(6;9) DEK::NUP214 Acute Myeloid Leukemia resembles that of FLT3-ITD/NPM1 Acute Myeloid Leukemia but with an altered HOX/MEIS axis

t(6;9) DEK::NUP214 急性髓系白血病中的基因调控与 FLT3-ITD/NPM1 急性髓系白血病相似,但 HOX/MEIS 轴发生改变。

Potluri, Sandeep; Kellaway, Sophie G; Coleman, Daniel J L; Keane, Peter; Imperato, Maria Rosaria; Assi, Salam A; Cockerill, Peter N; Bonifer, Constanze

Genome-scale clustered regularly interspaced short palindromic repeats screen identifies nucleotide metabolism as an actionable therapeutic vulnerability in diffuse large B-cell lymphoma.

基因组规模的规律成簇间隔短回文重复序列筛选发现核苷酸代谢是弥漫性大B细胞淋巴瘤中可操作的治疗弱点

Davies Nicholas, Francis Tegan, Oldreive Ceri, Azam Maria, Wilson Jordan, Byrd Philip J, Burley Megan, Sharma-Oates Archana, Keane Peter, Alatawi Sael, Higgs Martin R, Rudzki Zbigniew, Ibrahim Maha, Perry Tracey, Agathanggelou Angelo, Hewitt Anne-Marie, Smith Edward, Bonifer Constanze, O'Connor Mark, Forment Josep V, Murray Paul G, Fennell Eanna, Kelly Gemma, Chang Catherine, Stewart Grant S, Stankovic Tatjana, Kwok Marwan, Taylor Alexander Malcolm

Regulation of developmentally controlled enhancer activity by extrinsic signals in normal and malignant cells: AP-1 at the centre

正常细胞和恶性细胞中外源信号对发育控制增强子活性的调控:AP-1 处于中心地位

Maytum, Alexander; Obier, Nadine; Cauchy, Pierre; Bonifer, Constanze

Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment

基因调控网络和信号通路重连:血癌细胞如何改变形态以逃避药物治疗

Bonifer, Constanze; Cockerill, Peter N

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

基因调控网络分析预测了FLT3-ITD+ AML生长所需的协同转录因子调控子。

Coleman, Daniel J L; Keane, Peter; Luque-Martin, Rosario; Chin, Paulynn S; Blair, Helen; Ames, Luke; Kellaway, Sophie G; Griffin, James; Holmes, Elizabeth; Potluri, Sandeep; Assi, Salam A; Bushweller, John; Heidenreich, Olaf; Cockerill, Peter N; Bonifer, Constanze

Identification and characterization of enhancer elements controlling cell type-specific and signalling dependent chromatin programming during hematopoietic development

鉴定和表征造血发育过程中控制细胞类型特异性和信号依赖性染色质编程的增强子元件

Maytum, Alexander; Edginton-White, Ben; Bonifer, Constanze