文献库，生知库 | 链接生命科学的每一步

Chen, Shuang; Yu, Muchen; Xu, Manming; Decherchi, Sergio; Taracila, Magdalena A; Hujer, Andrea M; Bethel, Christopher R; Bonomo, Robert A; Haider, Shozeb

发表日期：2026

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Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

Ω环突变通过调节PDC-3 β-内酰胺酶中的氢键网络来控制活性位点的动力学。

期刊:Elife

影响因子:6.4

doi:10.7554/eLife.107688

Chen, Shuang; Mack, Andrew R; Hujer, Andrea M; Bethel, Christopher R; Bonomo, Robert A; Haider, Shozeb

发表日期：2026

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Vitamin B12 promotes cefiderocol resistance and small-colony variants in carbapenem-resistant Acinetobacter baumannii

维生素B12促进耐碳青霉烯类鲍曼不动杆菌产生头孢地洛耐药性和小菌落变异株。

期刊:mBio

影响因子:4.7

doi:10.1128/mbio.03760-25

Mezcord, Vyanka; Luu, Irene; Akhar, Usman; Traglia, German M; Rodríguez, Cecilia; Moheb, Samyar; Sanchez, Shayra D; Soto, Maria T; Cima Clave, Maria J; Sieira, Rodrigo; Tuttobene, Marisel R; Corso, Alejandra; Tolmasky, Marcelo E; Bonomo, Robert A; Actis, Luis A; Rao, Gauri; Pasteran, Fernando; Ramirez, Maria S

发表日期：2026

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Zinc starvation uncovers bacterial host-specific proteases that shape NDM adaptability in Acinetobacter baumannii

锌饥饿揭示了鲍曼不动杆菌中影响NDM适应性的细菌宿主特异性蛋白酶

期刊:mBio

影响因子:4.7

doi:10.1128/mbio.03447-25

Parodi, Clarisa; Saposnik, Lucas; Martino, Román A; Ramirez, María Soledad; Cassataro, Juliana; Smania, Andrea M; Bonomo, Robert A; Vila, Alejandro J; González, Lisandro J

微生物学

发表日期：2026

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A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant Klebsiella pneumoniae isolates with diverse phenotypic and genotypic resistance mechanisms

基于机制的药代动力学/药效学分析：以多粘菌素B为基础的联合疗法对抗具有不同表型和基因型耐药机制的碳青霉烯类耐药肺炎克雷伯菌分离株。

期刊:Antimicrobial Agents and Chemotherapy

影响因子:4.5

doi:10.1128/aac.00782-25

Mahadevan, Ramya; Garcia, Estefany; Sharma, Rajnikant; Qiu, Hongqiang; Elsheikh, Ahmed; Parambi, Robert; Abboud, Cely Saad; Pasteran, Fernando; Ramirez, Maria Soledad; Kaye, Keith S; Bonomo, Robert A; Rao, Gauri G

肺炎

发表日期：2026

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Impact of Pseudomonas aeruginosa biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity

铜绿假单胞菌生物膜胞外多糖组成对噬菌体及噬菌体-抗生素联合用药活性的影响

期刊:Antimicrobial Agents and Chemotherapy

影响因子:4.5

doi:10.1128/aac.00925-25

Van Helden, Sean R; Bleick, Callan R; Holger, Dana J; El Ghali, Amer; Alexander, Jose; Kaye, Keith S; Marshall, Steven H; Rojas, Laura J; Bonomo, Robert A; Lehman, Susan M; Rybak, Michael J

微生物学

发表日期：2026

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Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-based model

氨苄西林/舒巴坦联合头孢他啶/阿维巴坦治疗产金属β-内酰胺酶的耐碳青霉烯类鲍曼不动杆菌：基于基因组学机制的模型

期刊:Journal of Infectious Diseases

影响因子:4.5

doi:10.1093/infdis/jiaf567

Arun, Bhavatharini; Liu, Eloise; Vallé, Quentin; Sharma, Rajnikant; Bui, Ngoc Minh; Mezcord, Vyanka; Luu, Irene; Traglia, German Matias; Pasteran, Fernando; Paterson, David; Bonomo, Robert A; Ramirez, María Soledad; Rao, Gauri G

发表日期：2026

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Exploring the activity of a novel orally bioavailable β-lactam-β-lactamase inhibitor combination, ceftibuten-ledaborbactam, against Enterobacterales-carrying bla(OXA-48)

探索一种新型口服生物利用度高的β-内酰胺-β-内酰胺酶抑制剂组合头孢布烯-雷达博巴坦对携带bla(OXA-48)基因的肠杆菌科细菌的活性

期刊:Microbiology Spectrum

影响因子:3.8

doi:10.1128/spectrum.03148-25

Mojica, Maria F; Zeiser, Elise T; Becka, Scott A; Six, David A; Moeck, Greg; Bonomo, Robert A; Papp-Wallace, Krisztina M

微生物学

发表日期：2026

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Enterobacter hormaechei co-harbouring bla (KPC-2), bla (VIM-24), and bla (NDM-1): the rise of the 'unholy trinity'

霍氏肠杆菌共携带 bla (KPC-2)、bla (VIM-24) 和 bla (NDM-1)： “邪恶三位一体”的崛起

期刊:JACAntimicrobial Resistance

影响因子:3.7

doi:10.1093/jacamr/dlag025

Rojas, Laura J; De La Cadena, Elsa; Marshall, Steven H; Rudin, Susan D; García, Pilar; Serrano, Norma C; Meneses, Ligia Stella; Villegas, María V; Bonomo, Robert A

发表日期：2026

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Cryptic Binding Pockets in PDC‑3 β‑Lactamase Modulate Resistance Profiles

PDC-3 β-内酰胺酶中的隐蔽结合口袋调节耐药谱

Structural and Kinetic Basis for the Rational Design of Next-Generation β-Lactamase Inhibitors

下一代β-内酰胺酶抑制剂合理设计的结构和动力学基础

Ω-Loop mutations control dynamics of the active site by modulating the hydrogen-bonding network in PDC-3 β-lactamase

Ω环突变通过调节PDC-3 β-内酰胺酶中的氢键网络来控制活性位点的动力学。

Vitamin B12 promotes cefiderocol resistance and small-colony variants in carbapenem-resistant Acinetobacter baumannii

维生素B12促进耐碳青霉烯类鲍曼不动杆菌产生头孢地洛耐药性和小菌落变异株。

Zinc starvation uncovers bacterial host-specific proteases that shape NDM adaptability in Acinetobacter baumannii

锌饥饿揭示了鲍曼不动杆菌中影响NDM适应性的细菌宿主特异性蛋白酶

A mechanism-based pharmacokinetic/pharmacodynamic analysis of polymyxin B-based combination therapy against carbapenem-resistant Klebsiella pneumoniae isolates with diverse phenotypic and genotypic resistance mechanisms

基于机制的药代动力学/药效学分析：以多粘菌素B为基础的联合疗法对抗具有不同表型和基因型耐药机制的碳青霉烯类耐药肺炎克雷伯菌分离株。

Impact of Pseudomonas aeruginosa biofilm exopolysaccharide composition on bacteriophage and bacteriophage-antibiotic combination activity

铜绿假单胞菌生物膜胞外多糖组成对噬菌体及噬菌体-抗生素联合用药活性的影响

Ampicillin/Sulbactam in Combination with Ceftazidime/Avibactam Against Metallo-β-Lactamase-Producing Carbapenem-Resistant Acinetobacter baumannii: A Genomics-Informed Mechanism-based model

氨苄西林/舒巴坦联合头孢他啶/阿维巴坦治疗产金属β-内酰胺酶的耐碳青霉烯类鲍曼不动杆菌：基于基因组学机制的模型

Exploring the activity of a novel orally bioavailable β-lactam-β-lactamase inhibitor combination, ceftibuten-ledaborbactam, against Enterobacterales-carrying bla(OXA-48)

探索一种新型口服生物利用度高的β-内酰胺-β-内酰胺酶抑制剂组合头孢布烯-雷达博巴坦对携带bla(OXA-48)基因的肠杆菌科细菌的活性

Enterobacter hormaechei co-harbouring bla (KPC-2), bla (VIM-24), and bla (NDM-1): the rise of the 'unholy trinity'

霍氏肠杆菌共携带 bla (KPC-2)、bla (VIM-24) 和 bla (NDM-1)： “邪恶三位一体”的崛起