日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mechanistic insights into dual-active liver and blood-stage antiplasmodials

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat, Mukul; Boonyalai, Nonlawat; Smidt, Cindy; Luth, Madeline R; Chen, Daisy; Plater, Andrew; Post, John; Lin, De; McMillan, Joel; Eadsforth, Thomas; Moliner-Cubel, Sonia; Billker, Oliver; Rayner, Julian C; Gamo, Fransisco-Javier; Baragaña, Beatriz; Winzeler, Elizabeth A; Lee, Marcus C S

Protein Arginine Methyltransferase Inhibitors Target Multiple Stages of Plasmodium falciparum Parasites In Vitro

蛋白质精氨酸甲基转移酶抑制剂在体外靶向恶性疟原虫的多个发育阶段

Opperman, Daniel; Rabie, Tayla; Maré, Marché; Naude, Mariska; van der Watt, Mariette; Thibaud, Jessica L; Shannon, Megan; Sanders, Nicole; Bolscher, Judith M; van der Laak, Rianne; Willemsen, Rowy; Bronkhorst, Alfred; Boonyalai, Nonlawat; Lee, Marcus C S; Birkholtz, Lyn-Marié

Targeting Aurora Kinases as Essential Cell-Cycle Regulators to Deliver Multi-Stage Antimalarials Against Plasmodium Falciparum

以 Aurora 激酶为关键细胞周期调节因子,开发针对恶性疟原虫的多阶段抗疟药物

Langeveld, Henrico; Maepa, Keletso; Maree, Marché; Thibaud, Jessica L; Salomane, Nicolaas; Bridgwater, Rosie; Famodimu, Mufuliat T; Godoy, Luiz C; Pasaje, Charisse Flerida A; Boonyalai, Nonlawat; de Souza, Mariana Laureano; Fong, Justin; Rabie, Tayla; van der Watt, Mariëtte; Theart, Rensu P; Ghidelli-Disse, Sonja; Niles, Jacquin C; Lee, Marcus C S; Winzeler, Elizabeth A; Delves, Michael J; Chibale, Kelly; Wicht, Kathryn J; Coulson, Lauren B; Birkholtz, Lyn-Marié

Optimization and Characterization of the Antimalarial Activity of N-Aryl Acetamides that are Susceptible to Mutations in ROM8 and CSC1

对易受ROM8和CSC1突变影响的N-芳基乙酰胺类化合物的抗疟活性进行优化和表征

Nguyen, William; Boulet, Coralie; Dans, Madeline G; Loi, Katie; Jarman, Kate E; Barnes, Claudia B G; Yeo, Tomas; Sheth, Tanaya; Mukherjee, Partha; Chakraborty, Arnish; Famodimu, Mufuliat T; Delves, Michael J; Pollard, Harry; Sutherland, Colin J; Coyle, Rachael; Sevilleno, Nicole; Boonyalai, Nonlawat; Lee, Marcus C S; Rabie, Tayla; Birkholtz, Lyn-Marié; Baud, Delphine; Brand, Stephen; Chowdury, Mrittika; de Koning-Ward, Tania F; Fidock, David A; Gilson, Paul R; Sleebs, Brad E

Optimization of 2,8-Diaryl-1,5-naphthyridines as Plasmodium falciparum Phosphatidylinositol 4-Kinase Inhibitors with Improved ADME Profiles and In Vivo Efficacy

优化 2,8-二芳基-1,5-萘啶类化合物作为恶性疟原虫磷脂酰肌醇 4-激酶抑制剂,以改善其 ADME 特性和体内疗效

Dziwornu, Godwin A; Seanego, Donald; Fienberg, Stephen; Sypu, Venkata S; Salomane, Nicolaas; Krugmann, Liezl; Taylor, Dale; Masike, Keabetswe; Njoroge, Mathew; Boonyalai, Nonlawat; Lee, Marcus C S; Godoy, Luiz C; Pasaje, Charisse Flerida; Niles, Jacquin C; Basarab, Gregory S; Coulson, Lauren B; Ghorpade, Sandeep R; Chibale, Kelly

Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity

一种具有抗疟活性的II型人激酶抑制剂可抑制恶性疟原虫蛋白激酶6和血红素的形成。

Flore Nardella ,Tiantian Jiang ,Lushun Wang ,Monica J Bohmer ,Subhoja Chakraborty ,John Okombo ,Jaeson Calla ,Tatiane Macedo Silva ,Samuel Pazicky ,Jianwei Che ,Jin Jeon ,Evie Vincent ,Nonlawat Boonyalai ,Rachael Coyle ,Mairi J Buchanan ,Samuel Schaefer ,Daisy Chen ,Amaan Khan ,Emily Mayville ,Mariana Laureano De Souza ,Mayland Treat ,Jordan Charlton ,Patrick K Tumwebaze ,Seth Tjia ,Lukas Montejo ,Karen Cover ,Philip J Rosenthal ,Roland A Cooper ,Zbynek Bozdech ,Marcus C S Lee ,Ratna Chakrabarti ,Sanjay A Desai ,David A Fidock ,Jinhua Wang ,Nathanael S Gray ,Elizabeth A Winzeler ,Debopam Chakrabarti

Preclinical in vitro and in vivo evaluation of omadacycline against multidrug-resistant Acinetobacter baumannii

奥马环素对多重耐药鲍曼不动杆菌的临床前体外和体内评价

Vanachayangkul, Pattaraporn; Ruamsap, Nattaya; Caridha, Diana; Imerbsin, Rawiwan; Ball, Erin; Chattagul, Supaksorn; Tungtang, Anchalee; Gonwong, Siriphan; Kodchakorn, Chanikarn; Lertsethtakarn, Paphavee; Silapong, Sasikorn; Chaisatit, Chaiyaporn; Khemnu, Nuanpan; Boudreaux, Daniel; Boonyalai, Nonlawat; Demons, Samandra; Pierce, Jessica V; Martin, Monica; Anastasiou, Diane; Serio, Alisa W; Vesely, Brian; Lanteri, Charlotte Anne

Shared Binding Site but Divergent Resistance Profiles Uncover Novel Resistance Mechanisms in Plasmodium HSP90 Inhibitors

疟原虫HSP90抑制剂的共同结合位点和不同的耐药谱揭示了新的耐药机制

Ko, Fu-Hsuan; Lukens, Amanda K; de Souza, Mariana Laureano; Foy, Alex; Hsiao, Jason; Ndiaye, Tolla; Okombo, John; Yeo, Tomas; Park, Heekuk; Uhlemann, Anne-Catrin; Boonyalai, Nonlawat; Kumpornsin, Krittikorn; Girling, Gareth; Pasaje, Charisse; Godoy, Luiz; Ottilie, Sabine; Durst, Gregory L; Chatterjee, Arnab; Niles, Jacquin; Lee, Marcus; Fidock, David A; Wirth, Dyann F; Winzeler, Elizabeth A

Mechanistic Insights into Dual-Active Liver and Blood-Stage Antiplasmodials.

对具有双重活性的肝期和血期抗疟药物的机制研究

Rawat Mukul, Boonyalai Nonlawat, Smidt Cindy, Luth Madeline R, Chen Daisy, Plater Andrew, Post John, Lin De, McMillan Joel, Eadsforth Thomas, Moliner-Cubel Sonia, Billker Oliver, Rayner Julian C, Gamo Francisco-Javier, Baragaña Beatriz, Winzeler Elizabeth A, Lee Marcus C S

Common Patterns and Unique Threats in Antimicrobial Resistance as Demonstrated by Global Gonococcal Surveillance

全球淋球菌监测揭示的抗菌素耐药性的共同模式和独特威胁

Le Van, Adriana; Rahman, Nazia; Sandy, Reuel; Dozier, Nelson; Smith, Hunter J; Martin, Melissa J; Bartlett, Katelyn V; Harncharoenkul, Krit; Nanava, Anna; Akhvlediani, Tamar; Rios, Paul; Mehta, Supriya D; Agingu, Walter; Byarugaba, Denis K; Wabwire-Mangen, Fred; Kibuuka, Hannah; Erima, Bernard; Kabatasi, Hope O; Attram, Naiki; Peerapongpaisarn, Dutsadee; Oransathit, Wilawan; Oransathit, Wirote; Suksawad, Umaporn; Lurchachaiwong, Woradee; Sriplienchan, Somchai; Boonyalai, Nonlawat; Somsri, Maneerat; Chaitaveep, Nithinart; Jerse, Ann; Garges, Eric