Boot-Handford Raymond P相关文献与解析，生知库

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

椎间盘含有内在的生物钟，这些生物钟受年龄和细胞因子调控，并与椎间盘退变有关。

doi:10.1136/annrheumdis-2016-209428

Dudek, Michal; Yang, Nan; Ruckshanthi, Jayalath Pd; Williams, Jack; Borysiewicz, Elzbieta; Wang, Ping; Adamson, Antony; Li, Jian; Bateman, John F; White, Michael R; Boot-Handford, Raymond P; Hoyland, Judith A; Meng, Qing-Jun

Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism

细胞内蛋白水解增加可减轻内质网应激相关侏儒症的疾病严重程度。

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI93094

Mullan, Lorna A; Mularczyk, Ewa J; Kung, Louise H; Forouhan, Mitra; Wragg, Jordan Ma; Goodacre, Royston; Bateman, John F; Swanton, Eileithyia; Briggs, Michael D; Boot-Handford, Raymond P

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

XBP1非依赖性UPR通路抑制内质网应激相关骨骼疾病中C/EBP-β介导的软骨细胞分化

期刊:PLoS Genetics

影响因子:

doi:10.1371/journal.pgen.1005505

Cameron, Trevor L; Bell, Katrina M; Gresshoff, Irma L; Sampurno, Lisa; Mullan, Lorna; Ermann, Joerg; Glimcher, Laurie H; Boot-Handford, Raymond P; Bateman, John F

Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia

在假性软骨发育不全的靶向小鼠模型中，软骨生长板中软骨细胞的异常凋亡受遗传背景和CHOP基因缺失的影响。

期刊:PLoS One

影响因子:2.6

doi:10.1371/journal.pone.0085145

Piróg, Katarzyna A; Irman, Andreja; Young, Siobhan; Halai, Poonam; Bell, Peter A; Boot-Handford, Raymond P; Briggs, Michael D

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

Armet/Manf 和 Creld2 是由二硫键异常形成引发的特殊内质网应激反应的组成部分：对遗传性骨骼疾病的意义

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddt383

Hartley, Claire L; Edwards, Sarah; Mullan, Lorna; Bell, Peter A; Fresquet, Maryline; Boot-Handford, Raymond P; Briggs, Michael D

内质网应激

发表日期：2013

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Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

对三种不同遗传性骨骼疾病小鼠模型的软骨蛋白质组进行分析，揭示了共同的和独特的疾病特征。

期刊:Biology Open

影响因子:1.7

doi:10.1242/bio.20135280

Bell, Peter A; Wagener, Raimund; Zaucke, Frank; Koch, Manuel; Selley, Julian; Warwood, Stacey; Knight, David; Boot-Handford, Raymond P; Thornton, David J; Briggs, Michael D

发表日期：2013

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The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis

小鼠软骨细胞中的生物钟调控着控制软骨稳态关键方面的基因。

期刊:

影响因子:

doi:10.1002/art.38035

Gossan, Nicole; Zeef, Leo; Hensman, James; Hughes, Alun; Bateman, John F; Rowley, Lynn; Little, Christopher B; Piggins, Hugh D; Rattray, Magnus; Boot-Handford, Raymond P; Meng, Qing-Jun

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

骨关节炎进展和终末期疾病中超氧化物歧化酶的下调

期刊:Annals of the Rheumatic Diseases

影响因子:20.6

doi:10.1136/ard.2009.119966

Scott, Jenny L; Gabrielides, Christos; Davidson, Rose K; Swingler, Tracey E; Clark, Ian M; Wallis, Gillian A; Boot-Handford, Raymond P; Kirkwood, Tom B L; Taylor, Robert W; Young, David A

关节炎

发表日期：2010

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A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia

小鼠模型为假性软骨发育不全和多发性骨骺发育不良常伴随的肌病和肌腱病提供了新的见解

期刊:Human Molecular Genetics

影响因子:3.2

doi:10.1093/hmg/ddp466

Piróg, Katarzyna A; Jaka, Oihane; Katakura, Yoshihisa; Meadows, Roger S; Kadler, Karl E; Boot-Handford, Raymond P; Briggs, Michael D

发育与干细胞

发表日期：2010

文献求助收藏

Gene cloning to clinical trials-the trials and tribulations of a life with collagen

从基因克隆到临床试验——胶原蛋白之路上的种种考验与磨难

The intervertebral disc contains intrinsic circadian clocks that are regulated by age and cytokines and linked to degeneration

椎间盘含有内在的生物钟，这些生物钟受年龄和细胞因子调控，并与椎间盘退变有关。

Increased intracellular proteolysis reduces disease severity in an ER stress-associated dwarfism

细胞内蛋白水解增加可减轻内质网应激相关侏儒症的疾病严重程度。

XBP1-Independent UPR Pathways Suppress C/EBP-β Mediated Chondrocyte Differentiation in ER-Stress Related Skeletal Disease

XBP1非依赖性UPR通路抑制内质网应激相关骨骼疾病中C/EBP-β介导的软骨细胞分化

Abnormal chondrocyte apoptosis in the cartilage growth plate is influenced by genetic background and deletion of CHOP in a targeted mouse model of pseudoachondroplasia

在假性软骨发育不全的靶向小鼠模型中，软骨生长板中软骨细胞的异常凋亡受遗传背景和CHOP基因缺失的影响。

Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases

Armet/Manf 和 Creld2 是由二硫键异常形成引发的特殊内质网应激反应的组成部分：对遗传性骨骼疾病的意义

Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures

对三种不同遗传性骨骼疾病小鼠模型的软骨蛋白质组进行分析，揭示了共同的和独特的疾病特征。

The circadian clock in murine chondrocytes regulates genes controlling key aspects of cartilage homeostasis

小鼠软骨细胞中的生物钟调控着控制软骨稳态关键方面的基因。

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

骨关节炎进展和终末期疾病中超氧化物歧化酶的下调

A mouse model offers novel insights into the myopathy and tendinopathy often associated with pseudoachondroplasia and multiple epiphyseal dysplasia

小鼠模型为假性软骨发育不全和多发性骨骺发育不良常伴随的肌病和肌腱病提供了新的见解