日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Pharmacological targeting of RIG-I can selectively activate the integrated stress response

通过药物靶向RIG-I可以选择性地激活整合应激反应。

Cuoco, Caroline A; Ren, Wen; Baron, Kelsey R; Gologo, Sakina; Perea, Valerie; Mathur, Prakhyat; Bora, Prerona; Ta, Amina; Chu, Alan; Aldakhlallah, Rama; Rhoades, Derek; Cole, Christian M; Tan, Ee Phie; Hou, William C; Yoon, Leonard; Guo, Xiaoyan; Rosarda, Jessica D; Baran, Phil S; Kampmann, Martin; Tillery, Lakeisha; Johnson, Kristen A; Powers, Evan T; Wiseman, R Luke; Kelly, Jeffery W

Drug repurposing screen identifies an HRI activating compound that promotes adaptive mitochondrial remodeling in MFN2-deficient cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑。

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Aldakhlallah Rama, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

Pharmacologic activation of integrated stress response kinases inhibits pathologic mitochondrial fragmentation.

整合应激反应激酶的药理学激活可抑制病理性线粒体碎片化

Baron Kelsey R, Oviedo Samantha, Krasny Sophia, Zaman Mashiat, Aldakhlallah Rama, Bora Prerona, Mathur Prakhyat, Pfeffer Gerald, Bollong Michael J, Shutt Timothy E, Grotjahn Danielle A, Wiseman R Luke

Optimizing PDIA1 Inhibition as a Strategy to Inhibit NLRP3 Inflammasome Activation and Activity.

优化 PDIA1 抑制作为抑制 NLRP3 炎症小体激活和活性的策略

Buasakdi Chavin, Stanton Caroline R, Bora Prerona, Chatterjee Priyadarshini, Bollong Michael J, Wiseman R Luke

Drug Repurposing Screen Identifies an HRI Activating Compound that Promotes Adaptive Mitochondrial Remodeling in MFN2-deficient Cells.

药物再利用筛选发现了一种 HRI 激活化合物,该化合物可促进 MFN2 缺陷细胞中的线粒体适应性重塑

Bora Prerona, Zaman Mashiat, Oviedo Samantha, Kutseikin Sergei, Madrazo Nicole, Mathur Prakhyat, Pannikkat Meera, Krasny Sophia, Chu Alan, Johnson Kristen A, Grotjahn Danielle A, Shutt Timothy E, Wiseman R Luke

The glycolytic metabolite methylglyoxal covalently inactivates the NLRP3 inflammasome.

糖酵解代谢产物甲基乙二醛通过共价键使 NLRP3 炎症小体失活

Stanton Caroline, Buasakdi Chavin, Sun Jie, Levitan Ian, Bora Prerona, Kutseikin Sergei, Wiseman R Luke, Bollong Michael J

Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation

利用酶/人工底物系统增强细胞过硫化物并减轻神经炎症

Bora, Prerona; Manna, Suman; Nair, Mrutyunjay A; Sathe, Rupali R M; Singh, Shubham; Sreyas Adury, Venkata Sai; Gupta, Kavya; Mukherjee, Arnab; Saini, Deepak K; Kamat, Siddhesh S; Hazra, Amrita B; Chakrapani, Harinath

Small molecule generators of biologically reactive sulfur species

生物活性硫物种的小分子生成器

Bora, Prerona; Chauhan, Preeti; Pardeshi, Kundansingh A; Chakrapani, Harinath