日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

High-throughput quantum-mechanics/molecular-mechanics (ONIOM) macromolecular crystallographic refinement with PHENIX/DivCon: the impact of mixed Hamiltonian methods on ligand and protein structure

利用 PHENIX/DivCon 进行高通量量子力学/分子力学 (ONIOM) 大分子晶体学精修:混合哈密顿量方法对配体和蛋白质结构的影响

Borbulevych, Oleg; Martin, Roger I; Westerhoff, Lance M

XModeScore: a novel method for accurate protonation/tautomer-state determination using quantum-mechanically driven macromolecular X-ray crystallographic refinement

XModeScore:一种利用量子力学驱动的大分子X射线晶体学精修进行精确质子化/互变异构体状态测定的新方法

Borbulevych, Oleg; Martin, Roger I; Tickle, Ian J; Westerhoff, Lance M

Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native pMHC Docking Mode

增加肽接触控制修饰的 TCR 的高亲和力结合,同时维持天然 pMHC 对接模式

David K Cole, Malkit Sami, Daniel R Scott, Pierre J Rizkallah, Oleg Y Borbulevych, Penio T Todorov, Ruth K Moysey, Bent K Jakobsen, Jonathan M Boulter, Brian M Baker, Yi Li

Loss of T cell antigen recognition arising from changes in peptide and major histocompatibility complex protein flexibility: implications for vaccine design

肽和主要组织相容性复合体蛋白质柔韧性变化导致 T 细胞抗原识别丧失:对疫苗设计的影响

Francis K Insaidoo, Oleg Y Borbulevych, Moushumi Hossain, Sujatha M Santhanagopolan, Tiffany K Baxter, Brian M Baker

Lysine Nzeta-decarboxylation switch and activation of the beta-lactam sensor domain of BlaR1 protein of methicillin-resistant Staphylococcus aureus

耐甲氧西林金黄色葡萄球菌BlaR1蛋白的赖氨酸Nζ脱羧开关和β-内酰胺传感器结构域的激活

Borbulevych, Oleg; Kumarasiri, Malika; Wilson, Brian; Llarrull, Leticia I; Lee, Mijoon; Hesek, Dusan; Shi, Qicun; Peng, Jeffrey; Baker, Brian M; Mobashery, Shahriar

TCRs used in cancer gene therapy cross-react with MART-1/Melan-A tumor antigens via distinct mechanisms

癌症基因治疗中使用的 TCR 通过不同的机制与 MART-1/Melan-A 肿瘤抗原发生交叉反应

Oleg Y Borbulevych, Sujatha M Santhanagopolan, Moushumi Hossain, Brian M Baker

Conformational melding permits a conserved binding geometry in TCR recognition of foreign and self molecular mimics

构象融合使 TCR 识别外来和自身分子模拟物时具有保守的结合几何结构

Oleg Y Borbulevych, Kurt H Piepenbrink, Brian M Baker

T cell receptor cross-reactivity directed by antigen-dependent tuning of peptide-MHC molecular flexibility

通过抗原依赖性肽-MHC分子柔韧性调节来指导T细胞受体交叉反应

Oleg Y Borbulevych, Kurt H Piepenbrink, Brian E Gloor, Daniel R Scott, Ruth F Sommese, David K Cole, Andrew K Sewell, Brian M Baker

Fluorine substitutions in an antigenic peptide selectively modulate T-cell receptor binding in a minimally perturbing manner

抗原肽中的氟取代以最小干扰的方式选择性调节 T 细胞受体结合

Kurt H Piepenbrink, Oleg Y Borbulevych, Ruth F Sommese, John Clemens, Kathryn M Armstrong, Clare Desmond, Priscilla Do, Brian M Baker

Structures of MART-126/27-35 Peptide/HLA-A2 complexes reveal a remarkable disconnect between antigen structural homology and T cell recognition.

MART-126/27-35 肽/HLA-A2 复合物的结构揭示了抗原结构同源性和 T 细胞识别之间的显著脱节

Borbulevych Oleg Y, Insaidoo Francis K, Baxter Tiffany K, Powell Daniel J Jr, Johnson Laura A, Restifo Nicholas P, Baker Brian M