日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Rigorous evaluation of pathological α-synucleinopathy transmissibility between animals in an experimental model

在实验模型中对动物间病理性α-突触核蛋白病的传播性进行严格评估

Sacino, Amanda N; Golde, Todd E; Borchelt, David R; Giasson, Benoit I; Moehle, Mark S

Fast and slow strains of misfolded mutant superoxide dismutase 1 in familial amyotrophic lateral sclerosis

家族性肌萎缩侧索硬化症中错误折叠突变超氧化物歧化酶 1 的快慢两种菌株

Xu, Guilian; Dillon, Kristy; Lopez, Amanda; Brkic, Selma; Fromholt, Susan; Ostrow, Lyle W; Glass, Jonathan D; Chakrabarty, Paramita; Ayers, Jacob I; Borchelt, David R

Efficient induction of motor neuron disease in transgenic G93A SOD1 mice by prion-like seeding

通过朊病毒样播种在转基因G93A SOD1小鼠中高效诱导运动神经元疾病

Xu, Guilian; Lopez, Amanda; Brkic, Selma; Fromholt, Susan; Chakrabarty, Paramita; Borchelt, David R

Correction: Collusion of α-Synuclein and Aβ aggravating co-morbidities in a novel prion-type mouse model

更正:α-突触核蛋白和Aβ的协同作用加剧了新型朊病毒型小鼠模型中的合并症

Lloyd, Grace M; Dhillon, Jess-Karan S; Gorion, Kimberly-Marie M; Riffe, Cara; Fromholt, Susan E; Xia, Yuxing; Giasson, Benoit I; Borchelt, David R

Hyperacetylation mimetics within the tau filament core inhibits prion-like propagation of misfolded tau

tau 丝核心内的高乙酰化模拟物可抑制错误折叠 tau 的朊病毒样传播

Ethan D Smith, Robert McKenna, Mario Mietzsch, David R Borchelt, Stefan Prokop, Paramita Chakrabarty

Humanized APOE genotypes influence lifespan independently of tau aggregation in the P301S mouse model of tauopathy

在 P301S 小鼠 tau 蛋白病模型中,人源化 APOE 基因型独立于 tau 聚集而影响寿命

Tristan Williams, Tim Bathe, Quan Vo, Patricia Sacilotto, Karen McFarland, Alejandra Jolie Ruiz, Gabriela P Hery, Patrick Sullivan, David R Borchelt, Stefan Prokop, Paramita Chakrabarty

Human tauopathy strains defined by phosphorylation in R1-R2 repeat domains of tau

人类 tau 蛋白病菌株通过 tau 的 R1-R2 重复域磷酸化定义

Ethan D Smith, Quan Vo, Benoit I Giasson, David R Borchelt, Stefan Prokop, Paramita Chakrabarty

Carboxyl truncation of α-synuclein occurs early and is influenced by human APOE genotype in transgenic mouse models of α-synuclein pathogenesis

α-突触核蛋白的羧基截断发生较早,并且在α-突触核蛋白致病性的转基因小鼠模型中受人类APOE基因型的影响。

Lloyd, Grace M; Long, Brooke; Quintin, Stephan; Sorrentino, Zachary A; Gorion, Kimberly-Marie M; Bell, Brach M; Carrillo, Denise; Sullivan, Patrick; Borchelt, David; Giasson, Benoit I

Multiple Factors Influence the Incubation Period of ALS Prion-like Transmission in SOD1 Transgenic Mice

多种因素影响SOD1转基因小鼠ALS朊病毒样传播的潜伏期

Ayers, Jacob I; Xu, Guilian; Lu, Qing; Dillon, Kristy; Fromholt, Susan; Borchelt, David R

Blood-based biomarkers of inflammation in amyotrophic lateral sclerosis

肌萎缩侧索硬化症的血液炎症生物标志物

Kim A Staats, David R Borchelt, Malú Gámez Tansey, James Wymer