日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Phase I, Open-Label, Multicenter, Dose-escalation Study of the Oral Selective FGFR Inhibitor Debio 1347 in Patients with Advanced Solid Tumors Harboring FGFR Gene Alterations

一项针对携带 FGFR 基因改变的晚期实体瘤患者的口服选择性 FGFR 抑制剂 Debio 1347 的 I 期、开放标签、多中心、剂量递增研究

Voss, Martin H; Hierro, Cinta; Heist, Rebecca S; Cleary, James M; Meric-Bernstam, Funda; Tabernero, Josep; Janku, Filip; Gandhi, Leena; Iafrate, A John; Borger, Darrell R; Ishii, Nobuya; Hu, Youyou; Kirpicheva, Yulia; Nicolas-Metral, Valerie; Pokorska-Bocci, Anna; Vaslin Chessex, Anne; Zanna, Claudio; Flaherty, Keith T; Baselga, Jose

PIK3CA activating mutations are associated with more disseminated disease at presentation and earlier recurrence in glioblastoma

PIK3CA激活突变与胶质母细胞瘤初诊时疾病播散程度更严重以及复发更早相关。

Tanaka, Shota; Batchelor, Tracy T; Iafrate, A John; Dias-Santagata, Dora; Borger, Darrell R; Ellisen, Leif W; Yang, Daniel; Louis, David N; Cahill, Daniel P; Chi, Andrew S

Enrichment of HER2 Amplification in Brain Metastases from Primary Gastrointestinal Malignancies

原发性胃肠道恶性肿瘤脑转移中HER2扩增富集

Mitra, Devarati; Clark, Jeffrey W; Shih, Helen A; Oh, Kevin S; Brastianos, Priscilla K; Wo, Jennifer Y; Strickland, Matthew R; Curry, William T; Parikh, Aparna R; Corcoran, Ryan B; Ryan, David P; Iafrate, A John; Borger, Darrell R; Lennerz, Jochen K; Hong, Theodore S

Primary tumor sidedness is an independent prognostic marker for survival in metastatic colorectal cancer: Results from a large retrospective cohort with mutational analysis

原发肿瘤侧别是转移性结直肠癌患者生存的独立预后指标:一项大型回顾性队列研究及突变分析的结果

Kamran, Sophia C; Clark, Jeffrey W; Zheng, Hui; Borger, Darrell R; Blaszkowsky, Lawrence S; Allen, Jill N; Kwak, Eunice L; Wo, Jennifer Y; Parikh, Aparna R; Nipp, Ryan D; Murphy, Janet E; Goyal, Lipika; Zhu, Andrew X; Iafrate, A John; Corcoran, Ryan B; Ryan, David P; Hong, Theodore S

A phase 2 and biomarker study of cabozantinib in patients with advanced cholangiocarcinoma.

卡博替尼治疗晚期胆管癌患者的 2 期临床试验及生物标志物研究

Goyal Lipika, Zheng Hui, Yurgelun Matthew B, Abrams Thomas A, Allen Jill N, Cleary James M, Knowles Michelle, Regan Eileen, Reardon Amanda, Khachatryan Anna, Jain Rakesh K, Nardi Valentina, Borger Darrell R, Duda Dan G, Zhu Andrew X

Elevation of Urinary 2-Hydroxyglutarate in IDH-Mutant Glioma

IDH突变型胶质瘤患者尿2-羟基戊二酸水平升高

Fathi, Amir T; Nahed, Brian V; Wander, Seth A; Iafrate, A John; Borger, Darrell R; Hu, Ranliang; Thabet, Ashraf; Cahill, Daniel P; Perry, Ashley M; Joseph, Christelle P; Muzikansky, Alona; Chi, Andrew S

Prognosis and Clinicopathologic Features of Patients With Advanced Stage Isocitrate Dehydrogenase (IDH) Mutant and IDH Wild-Type Intrahepatic Cholangiocarcinoma

晚期异柠檬酸脱氢酶(IDH)突变型和IDH野生型肝内胆管癌患者的预后和临床病理特征

Goyal, Lipika; Govindan, Aparna; Sheth, Rahul A; Nardi, Valentina; Blaszkowsky, Lawrence S; Faris, Jason E; Clark, Jeffrey W; Ryan, David P; Kwak, Eunice L; Allen, Jill N; Murphy, Janet E; Saha, Supriya K; Hong, Theodore S; Wo, Jennifer Y; Ferrone, Cristina R; Tanabe, Kenneth K; Chong, Dawn Q; Deshpande, Vikram; Borger, Darrell R; Iafrate, A John; Bardeesy, Nabeel; Zheng, Hui; Zhu, Andrew X

A phase 1/2 and biomarker study of preoperative short course chemoradiation with proton beam therapy and capecitabine followed by early surgery for resectable pancreatic ductal adenocarcinoma.

一项针对可切除胰腺导管腺癌的术前短期放化疗(质子束疗法和卡培他滨)后早期手术的 1/2 期生物标志物研究

Hong Theodore S, Ryan David P, Borger Darrell R, Blaszkowsky Lawrence S, Yeap Beow Y, Ancukiewicz Marek, Deshpande Vikram, Shinagare Shweta, Wo Jennifer Y, Boucher Yves, Wadlow Raymond C, Kwak Eunice L, Allen Jill N, Clark Jeffrey W, Zhu Andrew X, Ferrone Cristina R, Mamon Harvey J, Adams Judith, Winrich Barbara, Grillo Tarin, Jain Rakesh K, DeLaney Thomas F, Fernandez-del Castillo Carlos, Duda Dan G

Isocitrate dehydrogenase 1 (IDH1) mutation in breast adenocarcinoma is associated with elevated levels of serum and urine 2-hydroxyglutarate

乳腺腺癌中异柠檬酸脱氢酶1 (IDH1) 突变与血清和尿液中2-羟基戊二酸水平升高相关。

Fathi, Amir T; Sadrzadeh, Hossein; Comander, Amy H; Higgins, Michaela J; Bardia, Aditya; Perry, Ashley; Burke, Meghan; Silver, Regina; Matulis, Christina R; Straley, Kimberly S; Yen, Katharine E; Agresta, Sam; Kim, Hyeryun; Schenkein, David P; Borger, Darrell R

Genomic profiling of intrahepatic cholangiocarcinoma: refining prognosis and identifying therapeutic targets

肝内胆管癌的基因组分析:改善预后并确定治疗靶点

Zhu, Andrew X; Borger, Darrell R; Kim, Yuhree; Cosgrove, David; Ejaz, Aslam; Alexandrescu, Sorin; Groeschl, Ryan Thomas; Deshpande, Vikram; Lindberg, James M; Ferrone, Cristina; Sempoux, Christine; Yau, Thomas; Poon, Ronnie; Popescu, Irinel; Bauer, Todd W; Gamblin, T Clark; Gigot, Jean Francois; Anders, Robert A; Pawlik, Timothy M