日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication

一种靶向自身新抗原的CD4+TCR和一种靶向自身新抗原的CD8+TCR是肿瘤根除的必要且充分条件

Steven P Wolf ,Vasiliki Anastasopoulou ,Kimberley Drousch ,Markus I Diehl ,Boris Engels ,Poh Yin Yew ,Kazuma Kiyotani ,Yusuke Nakamura ,Karin Schreiber ,Hans Schreiber # ,Matthias Leisegang #

CAR'TCR-T cells co-expressing CD33-CAR and dNPM1-TCR as superior dual-targeting approach for AML treatment

共表达CD33-CAR和dNPM1-TCR的CAR'TCR-T细胞是治疗急性髓系白血病(AML)的优良双靶向疗法。

Karin Teppert ,Isabella Elias Yonezawa Ogusuku ,Caroline Brandes ,Vera Herbel ,Nora Winter ,Niels Werchau ,Svetlana Khorkova ,Christian Wöhle ,Nojan Jelveh ,Kevin Bisdorf ,Boris Engels ,Thomas Schaser ,Kathleen Anders ,Annette Künkele ,Dominik Lock

Antigen-independent activation enhances the efficacy of 4-1BB-costimulated CD22 CAR T cells

抗原非依赖性激活可增强 4-1BB 共刺激 CD22 CAR T 细胞的功效

Nathan Singh #, Noelle V Frey #, Boris Engels #, David M Barrett, Olga Shestova, Pranali Ravikumar, Katherine D Cummins, Yong Gu Lee, Raymone Pajarillo, Inkook Chun, Amy Shyu, Steven L Highfill, Andrew Price, Linlin Zhao, Liaomin Peng, Brian Granda, Melissa Ramones, Xueqing Maggie Lu, David A Christ

Pancreatic cancer therapy with combined mesothelin-redirected chimeric antigen receptor T cells and cytokine-armed oncolytic adenoviruses

采用间皮素重定向嵌合抗原受体T细胞和细胞因子武装溶瘤腺病毒联合治疗胰腺癌

Keisuke Watanabe ,Yanping Luo ,Tong Da ,Sonia Guedan ,Marco Ruella ,John Scholler ,Brian Keith ,Regina M Young ,Boris Engels ,Suvi Sorsa ,Mikko Siurala ,Riikka Havunen ,Siri Tähtinen ,Akseli Hemminki ,Carl H June

Tumour ischaemia by interferon-γ resembles physiological blood vessel regression

干扰素-γ引起的肿瘤缺血类似于生理性血管退化。

Thomas Kammertoens ,Christian Friese ,Ainhoa Arina ,Christian Idel ,Dana Briesemeister ,Michael Rothe ,Andranik Ivanov ,Anna Szymborska ,Giannino Patone ,Severine Kunz ,Daniel Sommermeyer ,Boris Engels ,Matthias Leisegang ,Ana Textor ,Hans Joerg Fehling ,Marcus Fruttiger ,Michael Lohoff ,Andreas Herrmann ,Hua Yu ,Ralph Weichselbaum ,Wolfgang Uckert ,Norbert Hübner ,Holger Gerhardt ,Dieter Beule ,Hans Schreiber ,Thomas Blankenstein

Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma

针对癌症相关膜黏蛋白 MUC1 的 Tn-糖基形式的工程化 CAR-T 细胞可控制腺癌

Avery D Posey Jr, Robert D Schwab, Alina C Boesteanu, Catharina Steentoft, Ulla Mandel, Boris Engels, Jennifer D Stone, Thomas D Madsen, Karin Schreiber, Kathleen M Haines, Alexandria P Cogdill, Taylor J Chen, Decheng Song, John Scholler, David M Kranz, Michael D Feldman, Regina Young, Brian Keith, 

Eradication of Large Solid Tumors by Gene Therapy with a T-Cell Receptor Targeting a Single Cancer-Specific Point Mutation

通过针对单个癌症特异性点突变的 T 细胞受体基因疗法根除大型实体肿瘤

Matthias Leisegang, Boris Engels, Karin Schreiber, Poh Yin Yew, Kazuma Kiyotani, Christian Idel, Ainhoa Arina, Jaikumar Duraiswamy, Ralph R Weichselbaum, Wolfgang Uckert, Yusuke Nakamura, Hans Schreiber

Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma

针对胶质母细胞瘤的人源化抗 EGFR 变体 III 嵌合抗原受体 T 细胞的合理开发和表征

Laura A Johnson, John Scholler, Takayuki Ohkuri, Akemi Kosaka, Prachi R Patel, Shannon E McGettigan, Arben K Nace, Tzvete Dentchev, Pramod Thekkat, Andreas Loew, Alina C Boesteanu, Alexandria P Cogdill, Taylor Chen, Joseph A Fraietta, Christopher C Kloss, Avery D Posey Jr, Boris Engels, Reshma Singh

Relapse or eradication of cancer is predicted by peptide-major histocompatibility complex affinity

肽-主要组织相容性复合物亲和力可预测癌症的复发或根除

Boris Engels, Victor H Engelhard, John Sidney, Alessandro Sette, David C Binder, Rebecca B Liu, David M Kranz, Stephen C Meredith, Donald A Rowley, Hans Schreiber

MHC-class I-restricted CD4 T cells: a nanomolar affinity TCR has improved anti-tumor efficacy in vivo compared to the micromolar wild-type TCR

MHC I 类限制性 CD4 T 细胞:与微摩尔野生型 TCR 相比,纳摩尔亲和力 TCR 在体内具有更高的抗肿瘤功效

Carolina M Soto, Jennifer D Stone, Adam S Chervin, Boris Engels, Hans Schreiber, Edward J Roy, David M Kranz