日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Initial sites of SIV rebound after antiretroviral treatment cessation in rhesus macaques

恒河猴停止抗逆转录病毒治疗后SIV病毒反弹的初始部位

Keele, Brandon F; Okoye, Afam A; Immonen, Taina T; Varco-Merth, Benjamin; Duell, Derick; Nkoy, Candice; Goodwin, William; Hoffmeister, Shelby; Hughes, Colette M; Kose, Emek; Conchas, Andrew; Goodman, Charles A; Fennessey, Christine M; Macairan, Agatha; Bosche, William J; Fast, Randy; Homick, Christopher M; Hull, Mike; Oswald, Kelli; Shoemaker, Rebecca; Silipino, Lorna; Welker, Jorden L; Smedley, Jeremy; Labriola, Caralyn S; Axthelm, Michael K; Hansen, Scott G; Estes, Jacob D; Barouch, Dan H; Lifson, Jeffrey D; Picker, Louis J

Boosting SIV-specific CD8+ T cell responses prior to ART interruption extends time to SIVmac239 rebound.

在 ART 中断之前增强 SIV 特异性 CD8+ T 细胞反应可延长 SIVmac239 反弹的时间。

Omange Were R, Varco-Merth Benjamin D, Fadeyi Omo, Marenco Alejandra, Takata Hiroshi, Duell Derick M, Goodwin William D, Armitage Paula, Fennessey Christine M, Kose Emek, Immonen Taina T, Kosmider Ewelina, Bosche William J, Fast Randy, Homick Chris, Oswald Kelli, Shoemaker Rebecca, Bochart Rachele, MacAllister Rhonda, Labriola Caralyn S, Smedley Jeremy V, Axthelm Michael K, Edlefsen Paul T, Keele Brandon F, Lifson Jeffrey D, Gergen Janina, Petsch Benjamin, Rauch Susanne, Picker Louis J, Okoye Afam A

The TLR7 agonist vesatolimod does not measurably induce SIV expression in macaques receiving combination antiretroviral therapy initiated during chronic infection

TLR7激动剂vesatolimod在接受慢性感染期间开始的联合抗逆转录病毒疗法的猕猴中,不能显著诱导SIV表达。

Swanstrom, Adrienne E; Oswald, Kelli; Fast, Randy; Shoemaker, Rebecca; Thomas, James A; Pyle, Cathi; Hull, Michael; Bosche, William J; Li, Yuan; Breed, Matthew W; Kramer, Joshua A; Donohue, Duncan; Trubey, Charles M; Deleage, Claire; Geleziunas, Romas; Lifson, Jeffrey D; Del Prete, Gregory Q

Microtubule polymerization generates microtentacles important in circulating tumor cell invasion

微管聚合产生微触手,微触手在循环肿瘤细胞侵袭中起重要作用。

Kainka, Lucina; Shaebani, Reza; Kaiser, Kathi; Bosche, Jonas; Santen, Ludger; Lautenschläger, Franziska

Identification of initial sites of SIV rebound after treatment cessation

确定治疗停止后SIV反弹的初始部位

Picker, Louis; Keele, Brandon; Okoye, Afam; Immonen, Taina; Varco-Merth, Benjamin; Duell, Derick; Nkoy, Candice; Goodwin, William; Hoffmeister, Shelby; Kose, Emek; Conchas, Andrew; Goodman, Charles; Fennessey, Christine; Macairan, Agatha; Bosche, William; Fast, Randy; Homick, Christopher; Hull, Michael; Oswald, Kelli; Shoemaker, Rebecca; Silipino, Lorna; Welker, Jorden; Smedley, Jeremy; Labriola, Caralyn; Axthelm, Michael; Estes, Jacob; Barouch, Dan; Lifson, Jeffrey

Widespread tissue distribution of transcriptionally active, clonally expanded HIV-1 proviruses despite suppressive antiretroviral therapy

尽管接受了抑制性抗逆转录病毒治疗,但转录活跃、克隆扩增的HIV-1前病毒仍广泛分布于各种组织中。

Imamichi, Hiromi; Natarajan, Ven; Scrimieri, Francesca; Smith, Mindy; Badralmaa, Yunden; Bosche, Marjorie; Hensien, Jack; Buerkert, Thomas; Chang, Weizhong; Sherman, Brad; Singh, Kanal; Lane, H Clifford

No evidence for ongoing replication on ART in SIV-infected macaques

没有证据表明SIV感染的猕猴在接受抗逆转录病毒治疗期间病毒仍在持续复制。

Immonen, Taina T; Fennessey, Christine M; Lipkey, Leslie; Newman, Laura; Macairan, Agatha; Bosche, Marjorie; Waltz, Nora; Del Prete, Gregory Q; Lifson, Jeffrey D; Keele, Brandon F

Impact of alemtuzumab-mediated lymphocyte depletion on SIV reservoir establishment and persistence

阿仑单抗介导的淋巴细胞耗竭对SIV病毒库建立和持续存在的影响

Benjamin Varco-Merth ,Morgan Chaunzwa ,Derick M Duell ,Alejandra Marenco ,William Goodwin ,Rachel Dannay ,Michael Nekorchuk ,Danica Shao ,Kathleen Busman-Sahay ,Christine M Fennessey ,Lorna Silipino ,Michael Hull ,William J Bosche ,Randy Fast ,Kelli Oswald ,Rebecca Shoemaker ,Rachele Bochart ,Rhonda MacAllister ,Caralyn S Labriola ,Jeremy V Smedley ,Michael K Axthelm ,Miles P Davenport ,Paul T Edlefsen ,Jacob D Estes ,Brandon F Keele ,Jeffrey D Lifson ,Sharon R Lewin ,Louis J Picker ,Afam A Okoye

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir

在感染SIV的恒河猴中,早期抗逆转录病毒疗法揭示了具有反弹能力的病毒库的多相、可饱和的动态积累过程。

Brandon F Keele ,Afam A Okoye ,Christine M Fennessey ,Benjamin Varco-Merth ,Taina T Immonen ,Emek Kose ,Andrew Conchas ,Mykola Pinkevych ,Leslie Lipkey ,Laura Newman ,Agatha Macairan ,Marjorie Bosche ,William J Bosche ,Brian Berkemeier ,Randy Fast ,Mike Hull ,Kelli Oswald ,Rebecca Shoemaker ,Lorna Silipino ,Robert J Gorelick ,Derick Duell ,Alejandra Marenco ,William Brantley ,Jeremy Smedley ,Michael Axthelm ,Miles P Davenport ,Jeffrey D Lifson ,Louis J Picker

Genetic Downregulation of GABAB Receptors from Oligodendrocyte Precursor Cells Protects Against Demyelination in the Mouse Spinal Cord

少突胶质细胞前体细胞的 GABAB 受体基因下调可防止小鼠脊髓脱髓鞘

Davide Gobbo, Phillip Rieder, Li-Pao Fang, Emeline Buttigieg, Moritz Schablowski, Elisa Damo, Nathalie Bosche, Eleonora Dallorto, Pascal May, Xianshu Bai, Frank Kirchhoff, Anja Scheller