日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Reliable repurposing of the antibody interactome inside the cell

细胞内抗体相互作用组的可靠再利用

O'Shea, Caitlin M; Shahzad, Rushba; Aghasoleimani, Kimia; Newman, Stuart; Panmanee, Jiraporn; Schalkwyk, Leonard C; Brooke, Greg N; Benson, Fiona E; Trimmer, James S; Bosco, Daryl A; Fujisawa, Takao; Ichijo, Hidenori; Cashman, Neil R; Engel, Stanislav; Wright, Gareth S A

Breaking β-sheets in FUS prion-like domain preserves phase separation and function but prevents aggregation and toxicity.

破坏 FUS 朊病毒样结构域中的 β 折叠可以保持相分离和功能,但可以防止聚集和毒性。

Wake Noah, Alcalde Juan, Jutzi Daniel, Bajaj Anjali, Kour Sukhleen, Barai Mayur, Weng Shuo-Lin, Cummings Samara, Zheng Tongyin, Anderson Eric N, Wang Szu-Huan, Puterbaugh Ryan, Bosco Daryl A, Schuster Benjamin S, Mittal Jeetain, Pandey Udai Bhan, Ruepp Marc-David, Fawzi Nicolas L

TDP-43 dysfunction leads to impaired proteostasis and predisposes mice to worse neurological outcomes after brain injury

TDP-43功能障碍会导致蛋白质稳态受损,并使小鼠在脑损伤后更容易出现更严重的神经系统后遗症。

Rotunno, Melissa S; Fowler-Magaw, Megan; Zhong, Jianjun; O'Hara, Kennedy; Wiggin, Elenore A; Cameron, Debra; Stallworth, Karly; Bouley, James; McEachern, Holly; Anadolu, Mina N; Nickerson, Jeffrey A; Tapper, Andrew R; Molas, Susanna; Massi, Francesca; Henninger, Nils; King, Oliver D; Bosco, Daryl A

Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury

基线体重和体重减轻与反复闭合性颅脑损伤后的神经功能缺损、组织学改变和死亡之间的差异性关联

Kahriman, Aydan; Bouley, James; Bosco, Daryl A; Shazeeb, Mohammed Salman; Henninger, Nils

Endoplasmic reticulum stress leads to accumulation of wild-type SOD1 aggregates associated with sporadic amyotrophic lateral sclerosis

内质网应激导致野生型SOD1聚集体的积累,这与散发性肌萎缩侧索硬化症有关。

Medinas, Danilo B; Rozas, Pablo; Martínez Traub, Francisca; Woehlbier, Ute; Brown, Robert H; Bosco, Daryl A; Hetz, Claudio

Artifacts to avoid while taking advantage of top-down mass spectrometry based detection of protein S-thiolation

利用自上而下质谱法检测蛋白质S-硫醇化时应避免的伪影

Auclair, Jared R; Salisbury, Joseph P; Johnson, Joshua L; Petsko, Gregory A; Ringe, Dagmar; Bosco, Daryl A; Agar, Nathalie Y R; Santagata, Sandro; Durham, Heather D; Agar, Jeffrey N

Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.

鉴定出肌萎缩侧索硬化症中暴露的超氧化物歧化酶 1 的错误折叠区域

Rotunno Melissa S, Auclair Jared R, Maniatis Stephanie, Shaffer Scott A, Agar Jeffrey, Bosco Daryl A

Functions of FUS/TLS from DNA repair to stress response: implications for ALS

FUS/TLS 的功能涵盖 DNA 修复和应激反应:对 ALS 的启示

Sama, Reddy Ranjith Kumar; Ward, Catherine L; Bosco, Daryl A

Autophagy meets fused in sarcoma-positive stress granules

自噬与肉瘤阳性应激颗粒融合

Matus, Soledad; Bosco, Daryl A; Hetz, Claudio

An emerging role for misfolded wild-type SOD1 in sporadic ALS pathogenesis

野生型SOD1错误折叠在散发性ALS发病机制中的新兴作用

Rotunno, Melissa S; Bosco, Daryl A