日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery and development of a new oxazolidinone with reduced toxicity for the treatment of tuberculosis

发现和开发一种毒性降低的新型噁唑烷酮类药物用于治疗结核病

Crowley, Brendan M; Boshoff, Helena I; Boving, Aidan; Tan, Vee Y; Zhu, Jianghai; Hoyt, Forrest; Miller, Randy R; Ehrhart, Julie; Boyce, Christopher W; Young, Katherine; Nantermet, Philippe G; Su, Jing; Yang, Lihu; Painter, Ronald E; Corcoran, Emily B; Hoar, Jason L; Oh, Sangmi; Holtzman, David L; Levi, Micha; Anderson, Aparna; Otieno, Monicah A; Zimmerman, Matthew; Kaya, Firat; Massoudi, Lisa M; Ramey, Michelle E; Bauman, Allison A; Lenaerts, Anne J; Roberston, Gregory T; Dartois, Véronique; Wells, Charles D; Barry, Clifton E 3rd; Olsen, David B

PET/CT imaging of tuberculosis lung lesions in marmosets treated with different drug regimens aligns with human clinical outcomes

对接受不同药物治疗方案的狨猴进行结核性肺部病变的PET/CT成像,结果与人类临床疗效相符。

Greenstein, Talia; Via, Laura E; Moraes, Mariana Pereira; Weiner, Danielle M; Dayao, Emmanuel K; Walker, April M; Abdi, Ayan; Fleegle, Joel D; Gomez, Felipe; Repoli, Katelyn M; Woodcock, Michael J; Boshoff, Helena I M; Egbelowo, Oluwaseun; Gausi, Kamunkhwala; Denti, Paolo; Kaya, Firat; Zimmerman, Matthew; Miller, Eric L; Dartois, Véronique A; Barry, Clifton E 3rd; Aldridge, Bree B

Identification and Evaluation of dibasic piperidines as novel cell wall inhibitors against Mycobacterium tuberculosis

鉴定和评价二元哌啶类化合物作为新型抗结核分枝杆菌细胞壁抑制剂

Naylor, Claire; Prosser, Gareth A; Bayliss, Tracy; Berle, Lila; Wallach, Joshua B; Kim, Heather; Olvera, Rodrigo Aguilera; Thompson, Stephen; Ioerger, Thomas R; Simpson, Laura; Casanueva, Ruth; Guijarro-Lopez, Laura; Read, Kevin D; Wyatt, Paul G; Schnappinger, Dirk; Barry, Clifton E; Green, Simon R; Boshoff, Helena I; Cleghorn, Laura A T

SuFEx-based antitubercular compound irreversibly inhibits Pks13

基于 SuFEx 的抗结核化合物不可逆地抑制 Pks13

Krieger, Inna V; Sukheja, Paridhi; Yang, Baiyuan; Tang, Su; Selle, Daniel; Woods, Ashley; Engelhart, Curtis; Kumar, Pradeep; Harbut, Michael B; Liu, Dongdong; Tsuda, Brendan; Qin, Bo; Bare, Grant A L; Li, Gencheng; Chi, Victor; Gambacurta, Julian; Hvizdos, Janine; Reagan, Matthew; Jones, Isabelle L; Massoudi, Lisa M; Woolhiser, Lisa K; Cascioferro, Alessandro; Kundrick, Erica; Singh, Parul; Reiley, William; Ioerger, Thomas R; Kandula, Dilipkumar Reddy; McCabe, Jacob W; Guo, Taijie; Alland, David; Boshoff, Helena I; Schnappinger, Dirk; Robertson, Gregory T; Mdluli, Khisi; Lee, Kyoung-Jin; Dong, Jiajia; Li, Shuangwei; Schultz, Peter G; Joseph, Sean B; Love, Melissa S; Sharpless, K Barry; Petrassi, H Michael; Chatterjee, Arnab K; Sacchettini, James C; McNamara, Case W

Sanfetrinem, an oral β-lactam antibiotic repurposed for the treatment of tuberculosis

Sanfetrinem,一种口服β-内酰胺类抗生素,被重新用于治疗结核病

Ramón-García, Santiago; González Del Río, Rubén; Arenaz-Callao, María Pilar; Boshoff, Helena I; Rullas, Joaquín; Anca, Sara; Cacho Izquierdo, Mónica; Porras de Francisco, Esther; Pérez Herrán, Esther; Santos-Villarejo, Angel; Mendoza-Losana, Alfonso; Ferrer-Bazaga, Santiago; Thompson, Charles J; Barros Aguirre, David; Bates, Robert H

Thioquinazolinones as Antituberculosis Agents Targeting Phosphopantetheinyl Transferase

硫代喹唑啉酮类化合物作为靶向磷酸泛酰巯基转移酶的抗结核药物

Singh, Amrita; Zwerneman, Logan T; Planck, Kyle; Kaneko, Takushi; Perkowski, Andrew J; Suh, Christine M; Alex, Alexander; Bean, James; Burns-Huang, Kristin; Zhang, David; Boshoff, Helena I M; Roubert, Christine; Krieger, Inna; Gardner, Mark; Cautain, Bastien; Cooper, Christopher B; Tanvir, Zaid; Sacchettini, James; Gold, Ben S; Rhee, Kyu Y; Fotouhi, Nader; Nathan, Carl F; Aubé, Jeffrey

Fragment-Based Development of Small Molecule Inhibitors Targeting Mycobacterium tuberculosis Cholesterol Metabolism.

基于片段的小分子抑制剂开发靶向结核分枝杆菌胆固醇代谢

Kavanagh Madeline E, McLean Kirsty J, Gilbert Sophie H, Amadi Cecilia N, Snee Matthew, Tunnicliffe Richard B, Arora Kriti, Boshoff Helena I M, Fanourakis Alexander, Rebollo-Lopez Maria Jose, Ortega Fatima, Levy Colin W, Munro Andrew W, Leys David, Abell Chris, Coyne Anthony G

Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors

结核分枝杆菌MmpL3抑制剂的常见生物学特性

Ames, Lauren; Allen, Renee; Boshoff, Helena I M; Cleghorn, Laura A T; Engelhart, Curtis A; Schnappinger, Dirk; Parish, Tanya

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of Mycobacterium tuberculosis

鉴定出一系列含有五氟苯基部分的化合物,该化合物靶向 Pks13 以抑制结核分枝杆菌的生长

Green, Simon R; Harrison, Justin R; Thompson, Stephen; Murugesan, Dinakaran; Libardo, M Daben J; Engelhart, Curtis A; Meshanni, Jaclynn; Fletcher, Daniel; Scullion, Paul; Edwards, Darren; Epemolu, Ola; Mutter, Nicole; Shishikura, Yoko; Riley, Jennifer; Ioerger, Thomas R; Roca Guillén, Jose Juan; López, Laura Guijarro; Read, Kevin D; Barry, Clifton E 3rd; Schnappinger, Dirk; Wyatt, Paul G; Boshoff, Helena I M; Cleghorn, Laura A T

Developing novel indoles as antitubercular agents and simulated annealing-based analysis of their binding with MmpL3

开发新型吲哚类化合物作为抗结核药物,并基于模拟退火方法分析其与MmpL3的结合

Ray, Rajdeep; Das, Stutee; Birangal, Sumit Raosaheb; Boshoff, Helena I; Roma, Jose Santinni; Lobo, Manisha; Hariharapura, Raghu Chandrashekhar; Shenoy, G Gautham