日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

BI-3406 是一种强效且选择性的 SOS1-KRAS 相互作用抑制剂,可通过联合 MEK 抑制有效治疗 KRAS 驱动的癌症

Marco H Hofmann #, Michael Gmachl #, Juergen Ramharter #, Fabio Savarese, Daniel Gerlach, Joseph R Marszalek, Michael P Sanderson, Dirk Kessler, Francesca Trapani, Heribert Arnhof, Klaus Rumpel, Dana-Adriana Botesteanu, Peter Ettmayer, Thomas Gerstberger, Christiane Kofink, Tobias Wunberg, Andreas Z

Untargeted Metabolomic Analysis Combined With Multivariate Statistics Reveal Distinct Metabolic Changes in GPR40 Agonist-Treated Animals Related to Bile Acid Metabolism

非靶向代谢组学分析结合多元统计分析揭示了GPR40激动剂治疗动物中与胆汁酸代谢相关的独特代谢变化

Doerfler, Hannes; Botesteanu, Dana-Adriana; Blech, Stefan; Laux, Ralf

Patients with BRCA mutated ovarian cancer may have fewer circulating MDSC and more peripheral CD8+ T cells compared with women with BRCA wild-type disease during the early disease course

与 BRCA 野生型卵巢癌患者相比,在早期疾病过程中,BRCA 突变卵巢癌患者的循环 MDSC 可能较少,而外周 CD8+ T 细胞可能较多

Jung-Min Lee, Dana-Adriana Botesteanu, Yusuke Tomita, Akira Yuno, Min-Jung Lee, Elise C Kohn, Christina M Annunziata, Ursula Matulonis, Lauren A MacDonald, Jayakumar R Nair, Kimberley M Macneill, Jane B Trepel

Prexasertib, a cell cycle checkpoint kinase 1 and 2 inhibitor, in BRCA wild-type recurrent high-grade serous ovarian cancer: a first-in-class proof-of-concept phase 2 study

Prexasertib(一种细胞周期检查点激酶 1 和 2 抑制剂)治疗 BRCA 野生型复发性高级别浆液性卵巢癌:一项首创的概念验证性 II 期研究

Lee, Jung-Min; Nair, Jayakumar; Zimmer, Alexandra; Lipkowitz, Stanley; Annunziata, Christina M; Merino, Maria J; Swisher, Elizabeth M; Harrell, Maria I; Trepel, Jane B; Lee, Min-Jung; Bagheri, Mohammad H; Botesteanu, Dana-Adriana; Steinberg, Seth M; Minasian, Lori; Ekwede, Irene; Kohn, Elise C

Universal response in the RKO colon cancer cell line to distinct antimitotic therapies

RKO结肠癌细胞系对不同的抗有丝分裂疗法均有普遍反应

Lorz, Alexander; Botesteanu, Dana-Adriana; Levy, Doron

Safety and Clinical Activity of the Programmed Death-Ligand 1 Inhibitor Durvalumab in Combination With Poly (ADP-Ribose) Polymerase Inhibitor Olaparib or Vascular Endothelial Growth Factor Receptor 1-3 Inhibitor Cediranib in Women's Cancers: A Dose-Escalation, Phase I Study

程序性死亡配体 1 抑制剂度伐利尤单抗联合聚(ADP-核糖)聚合酶抑制剂奥拉帕尼或血管内皮生长因子受体 1-3 抑制剂西地尼布治疗女性癌症的安全性和临床活性:一项剂量递增的 I 期研究

Lee, Jung-Min; Cimino-Mathews, Ashley; Peer, Cody J; Zimmer, Alexandra; Lipkowitz, Stanley; Annunziata, Christina M; Cao, Liang; Harrell, Maria I; Swisher, Elizabeth M; Houston, Nicole; Botesteanu, Dana-Adriana; Taube, Janis M; Thompson, Elizabeth; Ogurtsova, Aleksandra; Xu, Haiying; Nguyen, Jeffers; Ho, Tony W; Figg, William D; Kohn, Elise C

Modeling Cancer Cell Growth Dynamics In vitro in Response to Antimitotic Drug Treatment

体外模拟癌细胞生长动力学对有丝分裂抑制剂治疗的反应

Lorz, Alexander; Botesteanu, Dana-Adriana; Levy, Doron

Modeling the Dynamics of High-Grade Serous Ovarian Cancer Progression for Transvaginal Ultrasound-Based Screening and Early Detection

构建高级别浆液性卵巢癌进展动态模型,用于经阴道超声筛查和早期检测

Botesteanu, Dana-Adriana; Lee, Jung-Min; Levy, Doron

Mathematical models of breast and ovarian cancers

乳腺癌和卵巢癌的数学模型

Botesteanu, Dana-Adriana; Lipkowitz, Stanley; Lee, Jung-Min; Levy, Doron