日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy

IFN-γ驱动的Th1细胞分化相对于Th17细胞分化的偏倚是CAR-T疗法中细胞因子释放综合征(CRS)和中性粒细胞减少症的根本原因。

Goala, Payal; Zhang, Yongliang; Beatty, Nolan; Pavy, Allan; McSain, Shannon; Sailer, Cooper; Tariq, Muhammad Junaid; Hamid, Showkat; Cortes Gomez, Eduardo; Wang, Jianmin; Massillon, Duna; Ilecki, Maxwell; Boucher, Justin C; Savid-Frontera, Constanza; Lee, Sae Bom; Kotani, Hiroshi; Stone, Meredith L; Jain, Michael D; Davila, Marco L

CD28 co-stimulatory domain enhances efficacy of CER T cell therapy compared to 4-1BB in an ovarian cancer mouse model

在卵巢癌小鼠模型中,与4-1BB相比,CD28共刺激结构域可增强CER T细胞疗法的疗效。

Beatty, Nolan J; Ma, Min; Goala, Payal; McSain, Shannon; Lee, Sae Bom; Boucher, Justin C; Stone, Meredith L; Kang, Yun Pyo; Cortes-Gomez, Eduardo; Wang, Jianmin; Qu, Jun; Davila, Marco L

Effector T cells under hypoxia have an altered transcriptome similar to tumor-stressed T cells found in non-responsive melanoma patients.

缺氧条件下的效应 T 细胞的转录组发生了改变,类似于在无反应性黑色素瘤患者中发现的肿瘤应激 T 细胞

Nagy Mate Z, Plaza-Rojas Lourdes B, Boucher Justin C, Kostenko Elena, Austin Anna L, Tarhini Ahmad A, Chen Zhihua, Du Dongliang, Ojwang' Awino Maureiq E, Davis Joshua, Obermayer Alyssa, Rejniak Katarzyna A, Shaw Timothy I, Guevara-Patino Jose A

The Th1/Th17 axis regulates chimeric antigen receptor (CAR) T cell therapy toxicities

Th1/Th17轴调节嵌合抗原受体(CAR)T细胞疗法的毒性

Goala, Payal; Zhang, Yongliang; Sailer, Cooper; McSain, Shannon; Tariq, Muhammad Junaid; Hamid, Showkat; Gomez, Eduardo Cortes; Wang, Jianmin; Boucher, Justin C; Frontera, Constanza Savid; Lee, Sae Bom; Kotani, Hiroshi; Jain, Michael; Davila, Marco L

Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers

在表达MYC的KRAS突变型癌症中,通过双重抑制SUMO化和MEK增强全面的抗肿瘤免疫反应

Kotani, Hiroshi; Yamano, Tomoyoshi; Boucher, Justin C; Sato, Shigeki; Sakaguchi, Hiroyuki; Fukuda, Koji; Nishiyama, Akihiro; Yamashita, Kaname; Ohtsubo, Koushiro; Takeuchi, Shinji; Nishiuchi, Takumi; Oshima, Hiroko; Oshima, Masanobu; Davila, Marco L; Yano, Seiji

Emerging CAR T Cell Strategies for the Treatment of AML

用于治疗急性髓系白血病的CAR-T细胞疗法的新兴策略

Vishwasrao, Paresh; Li, Gongbo; Boucher, Justin C; Smith, D Lynne; Hui, Susanta K

Generation of Antitumor T Cells For Adoptive Cell Therapy With Artificial Antigen Presenting Cells

利用人工抗原呈递细胞生成抗肿瘤T细胞用于过继细胞疗法

Shrestha, Bishwas; Zhang, Yongliang; Yu, Bin; Li, Gongbo; Boucher, Justin C; Beatty, Nolan J; Tsai, Ho-Chien; Wang, Xuefeng; Mishra, Asmita; Sweet, Kendra; Lancet, Jeffrey E; Kelley, Linda; Davila, Marco L

The eIF2α Kinase Heme-Regulated Inhibitor Protects the Host from Infection by Regulating Intracellular Pathogen Trafficking

eIF2α激酶血红素调节抑制剂通过调节细胞内病原体运输来保护宿主免受感染

Bahnan, Wael; Boucher, Justin C; Gayle, Petoria; Shrestha, Niraj; Rosen, Mark; Aktas, Bertal; Adkins, Becky; Ager, Arba; Khan, Wasif N; Schesser, Kurt