日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Perm1 Gene Therapy Mitigates PRDM16-Associated Cardiomyopathy

Perm1基因疗法可减轻PRDM16相关性心肌病

Rouzbehani, Omid Mt; Stephens, Sophie; Werbner, Ben; Szulik, Marta W; Sun, Bo; Hua, Mira; Watanabe, Shinya; Leonelli, Ava; Goodman, Michael; Bia, Ryan; Davey, Crystal F; Golkowski, Martin G; Franklin, Sarah; Landstrom, Andrew P; Boudina, Sihem

Excessive Ca(2+)-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury

EFHD1介导的过量Ca(2+)依赖性内质网-线粒体接触稳定作用导致肝损伤。

Eberhardt, David R; Rekate, Emma C; Masini, Yasmin B; Duron, Hannah E; Mollinedo, David; Velarde, Adrian M; Stucki, Devorah; Price, Tara; Lee, Sandra H J; Balderas, Enrique; Rai, Neeraj K; Bratt, Ashley R; Balynas, Anthony M; Stubben, Chris J; Bia, Ryan; Maity, Sudipa; Hartel, Nicolas; Yin, Xue; Corbin, Andrea; Kumari, Anshu; Nguyen, Dung M; Shimura, Daisuke; Nguyen, Vu D; Vinod, Vishaka; Chowdhury, Kamrul H; Verdeguer, Francisco; Zvick, Joel; Mimche, Patrice N; Boudina, Sihem; Drakos, Stavros G; Aromolaran, Ademuyiwa S; Franklin, Sarah; Garg, Vivek; Shaw, Robin M; Holland, William L; Summers, Scott A; Pezzolesi, Marcus G; Rutter, Jared; Evason, Kimberley J; Chaudhuri, Dipayan

Loss of hepatic autophagy induces α-cell proliferation through impaired glutamine-dependent gluconeogenesis.

肝脏自噬的丧失通过损害谷氨酰胺依赖性糖异生诱导α细胞增殖

Velasco-Silva Jesse N, Wilkerson Joseph L, Ramos Daniela, Low Hayden K, Bowman Faith, Evason Kimberley J, Boudina Sihem, Holland William L, Ducker Gregory S

Diet-induced MASH liver fibrosis promoted by EphB2 can be targeted by small molecule tetramerization inhibitors

饮食诱导的MASH肝纤维化是由EphB2促进的,可采用小分子四聚体抑制剂进行治疗。

Yoshigi, Masaaki; Kamdem, Severin Donald; Wang, Hanghang; Khambete, Amav; Sprouse, Francis; Kameni, Ernest M; Atiogue, Estelle; Pellizzari, Sarah; Evason, Kimberley J; Helms, My N; Goodman, Michael; Wang, Shuang; So, Jisun; Roh, Hyun Cheol; Boudina, Sihem; Henkemeyer, Mark; Mimche, Patrice N

N-acetylcarnosine attenuates age-associated declines in multi-organ systems to improve survival

N-乙酰肌肽可减轻与年龄相关的多器官系统功能衰退,从而提高生存率

Miranda, Edwin R; Shahtout, Justin L; Watanabe, Shinya; Spaas, Jan; Milam, Norah Y; Neiswanger, Grace; Werbner, Benjamin; Stuart, Deborah; Mookherjee, Sohom; Wilson, Jack; Judge, Michael; Goh, Isabella Y; Slater, Tyler; Gallop, Molly R; Hu, Guoli; Karasawa, Takuya; Landers, Jillian K; Rainbow, Bryann; O'Connor, Kyle T; Black, Nicholas J; Lan, He; Nikolova, Linda S; Li, Ying; Davey, Crystal F; Cox, James E; Boudina, Sihem; Karner, Courtney M; Harasymowicz, Natalia S; Ramkumar, Nirupama; Symons, J David; Chaix, Amandine; Long, Jonathan Z; Drummond, Micah J; Funai, Katsuhiko

Mitofusin-2 Regulates Platelet Mitochondria and Function

线粒体融合蛋白-2调节血小板线粒体及其功能

Jacob, Shancy; Kosaka, Yasuhiro; Bhatlekar, Seema; Denorme, Frederik; Benzon, Haley; Moody, Alexandra; Moody, Victoria; Tugolukova, Emilia A; Hull, Grayson; Kishimoto, Nina; Manne, Bhanu K; Guo, Li; Souvenir, Rhonda; Seliger, Brayden J; Eustes, Alicia S; Hoerger, Kelly; Tolley, Neal D; Fatahian, Amir N; Boudina, Sihem; Christiani, David C; Wei, Yongyue; Ju, Can; Campbell, Robert A; Rondina, Matthew T; Abel, E Dale; Bray, Paul F; Weyrich, Andrew S; Rowley, Jesse W

Stem cell secretome treatment improves whole-body metabolism, reduces adiposity, and promotes skeletal muscle function in aged mice

干细胞分泌组疗法可改善老年小鼠的全身代谢,减少脂肪堆积,并促进骨骼肌功能

Fennel, Zachary J; Bourrant, Paul-Emile; Kurian, Anu Susan; Petrocelli, Jonathan J; de Hart, Naomi M M P; Yee, Elena M; Boudina, Sihem; Keirstead, Hans S; Nistor, Gabrielle; Greilach, Scott A; Berchtold, Nicole C; Lane, Thomas E; Drummond, Micah J

Lipid-associated macrophages reshape BAT cell identity in obesity.

脂质相关巨噬细胞在肥胖症中重塑棕色脂肪组织细胞的特性

Sciarretta Francesca, Ninni Andrea, Zaccaria Fabio, Chiurchiù Valerio, Bertola Adeline, Karlinsey Keaton, Jia Wentong, Ceci Veronica, Di Biagio Claudia, Xu Ziyan, Gaudioso Francesco, Tortolici Flavia, Tiberi Marta, Zhang Jiabi, Carotti Simone, Boudina Sihem, Grumati Paolo, Zhou Beiyan, Brestoff Jonathan R, Ivanov Stoyan, Aquilano Katia, Lettieri-Barbato Daniele

Activating P2Y1 receptors improves function in arteries with repressed autophagy

激活P2Y1受体可改善自噬受到抑制的动脉功能

Cho, Jae Min; Park, Seul-Ki; Kwon, Oh Sung; Taylor La Salle, David; Cerbie, James; Fermoyle, Caitlin C; Morgan, David; Nelson, Ashley; Bledsoe, Amber; Bharath, Leena P; Tandar, Megan; Kunapuli, Satya P; Richardson, Russell S; Anandh Babu, Pon Velayutham; Mookherjee, Sohom; Kishore, Bellamkonda K; Wang, Fei; Yang, Tianxin; Boudina, Sihem; Trinity, Joel D; Symons, John David

Nonsense Variant PRDM16-Q187X Causes Impaired Myocardial Development and TGF-β Signaling Resulting in Noncompaction Cardiomyopathy in Humans and Mice

无义变异PRDM16-Q187X导致心肌发育和TGF-β信号传导受损,从而导致人类和小鼠出现致密性心肌病。

Sun, Bo; Rouzbehani, Omid M T; Kramer, Ryan J; Ghosh, Rajeshwary; Perelli, Robin M; Atkins, Sage; Fatahian, Amir Nima; Davis, Kathryn; Szulik, Marta W; Goodman, Michael A; Hathaway, Marissa A; Chi, Ellenor; Word, Tarah A; Tunuguntla, Hari; Denfield, Susan W; Wehrens, Xander H T; Whitehead, Kevin J; Abdelnasser, Hala Y; Warren, Junco S; Wu, Mingfu; Franklin, Sarah; Boudina, Sihem; Landstrom, Andrew P