日期 影响因子
日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:
–

A neurotensin receptor type 1-derived pepducin acts as a biased allosteric modulator to regulate target receptor function

神经降压素受体1型衍生肽素作为一种偏向性变构调节剂，可调节靶受体功能。

期刊:Acta Pharmaceutica Sinica B
影响因子:14.6
doi:10.1016/j.apsb.2025.12.043
Brouillette, Rebecca L; Lussier, Frédérique; Breault, Émile; Meneboo, Nathan; Hassanzadeh, Malihe; Tremblay, Victoria; Chartier, Magali; Midavaine, Élora; Ulrich, Laurence; Côté, Jérôme; Blais, Véronique; Mona, Christine E; Longpré, Jean-Michel; Grandbois, Michel; Boudreault, Pierre-Luc; Audet, Martin; Besserer-Offroy, Élie; Sarret, Philippe
信号转导
发表日期：2026
文献求助 收藏

TMPRSS2 inhibitors with broad-spectrum efficacy against SARS-CoV-2 (JN.1) and influenza A (H1N1) viruses protect mice from influenza A infection

TMPRSS2抑制剂对SARS-CoV-2（JN.1）和甲型流感（H1N1）病毒具有广谱疗效，并能保护小鼠免受甲型流感病毒感染。

期刊:Emerging Microbes & Infections
影响因子:7.5
doi:10.1080/22221751.2026.2616944
Presley, Lianne; Pérez-Vargas, Jimena; Saintigny, Anaïs; Villanueva, Iván; Ho, Michelle; Fone, Jessica; Brinsden, Lara; Kaushik, Nidhi; Olver, Syan; Thompson, Connor A H; Bautista-Sánchez, Diana; Ennis, Siobhan; Chen, Mike; McCallum, Matthew; Brown, Jack T; Ferková, Sára; Hetrick, Brian; Veesler, David; Leduc, Richard; Niikura, Masahiro; Boudreault, Pierre-Luc; Warner, Bryce; Jean, François
炎症/感染
流感
SARS-CoV-2
微生物学
发表日期：2026
文献求助 收藏

Tunable Biased Signaling of the Angiotensin II Type 1 Receptor for Inotropy via C-Terminal Peptide Engineering and Allosteric Site Targeting

通过C端肽工程和变构位点靶向调控血管紧张素II 1型受体的正性肌力信号传导

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01259
Hadjadj, Margot; Hassanzadeh, Malihe; Martel, Justin; Roy, Marie-Frédérique; Giguère, Hugo; Murza, Alexandre; Holleran, Brian J; Namkung, Yoon; Froehlich, Ulrike; Leduc, Richard; Auger-Messier, Mannix; Laporte, Stéphane A; Boudreault, Pierre-Luc
信号转导
发表日期：2026
文献求助 收藏

Androgen Receptor Point Mutations: A Mechanism of Therapeutic Resistance and a Framework for Rational Drug Design

雄激素受体点突变：一种治疗耐药机制和合理药物设计的框架

期刊:Cancers
影响因子:4.4
doi:10.3390/cancers18061043
Colah, Avan; Ferková, Sára; Zhang, Han; Liu, Glenn; MacGillivray, Leonard; Boudreault, Pierre-Luc; Ricke, William
信号转导
治疗耐药
免疫/内分泌
发表日期：2026
文献求助 收藏

Identification of skeletal muscle stem cell adhesion motifs using spot-synthesis-based peptide arrays.

利用基于点合成的肽阵列鉴定骨骼肌干细胞粘附基序。

期刊:iScience
影响因子:4.1
doi:10.1016/j.isci.2025.114498
Leblanc Elizabeth, Schüler Svenja C, Liu Yuguo, Théroux Léa, Le Moal Emmeran, Bonin Marc-André, Boudreault Pierre-Luc, Bentzinger C Florian
发育与干细胞
干细胞
发表日期：2026
文献求助 收藏

Biosensor-guided discovery of peptide inhibitors targeting the ribosomal protein uS5-PDCD2 chaperone interaction

生物传感器引导的靶向核糖体蛋白uS5-PDCD2分子伴侣相互作用的肽抑制剂的发现

期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2026.111415
Mir Hassani, Zabih; Goulet, Frédérique; Nguyen, Duc Tai; Landry-Voyer, Anne-Marie; Kwiatek, Lauren; Gaudet, Shany; Boudreault, Pierre-Luc; Azad, Taha; Bachand, François
CD2
发表日期：2026
文献求助 收藏

Structure-based design of macrocyclic peptides to generate functional antibodies against G protein-coupled receptors

基于结构的环状肽设计用于生成针对G蛋白偶联受体的功能性抗体

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66030-1
Nepveu-Traversy, Marie-Edith; Hassanzadeh, Malihe; Bruneau-Cossette, Laurent; Besserer-Offroy, Élie; Brouillette, Rebecca; Morissette, Sandra; Traboulsi, Hassan; Kirby, Karyn; Murza, Alexandre; Longpré, Jean-Michel; Breton, Billy; Gendron, Fernand-Pierre; Gaudreau, Simon; Boudreault, Pierre-Luc; Sarret, Philippe
信号转导
发表日期：2025
文献求助 收藏

TGFβ-Smad3 signaling restores cell-autonomous Srsf1-mediated splicing of fibronectin in aged skeletal muscle stem cells.

TGFβ-Smad3 信号传导恢复衰老骨骼肌干细胞中 Srsf1 介导的纤连蛋白的细胞自主剪接。

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-66582-2
Liu Yuguo, Schüler Svenja C, Dumontier Simon, Balg Frederic, Bedard Sonia, Desgeorges Thibaut, Feige Jerome N, Boudreault Pierre-Luc, Bentzinger C Florian
发育与干细胞
信号转导
衰老
干细胞
细胞生物学
TGFβ
发表日期：2025
文献求助 收藏

Structural basis of TMPRSS11D specificity and autocleavage activation.

TMPRSS11D 特异性和自切割激活的结构基础

期刊:Nature Communications
影响因子:15.7
doi:10.1038/s41467-025-59677-3
Fraser Bryan J, Wilson Ryan P, Ferková Sára, Ilyassov Olzhas, Lac Jackie, Dong Aiping, Li Yen-Yen, Seitova Alma, Li Yanjun, Hejazi Zahra, Kenney Tristan M G, Penn Linda Z, Edwards Aled, Leduc Richard, Boudreault Pierre-Luc, Morin Gregg B, Bénard François, Arrowsmith Cheryl H
发表日期：2025
文献求助 收藏

Structure-Guided Optimization of Selective Covalent Reversible Peptidomimetic Inhibitors Targeting TMPRSS6

结构导向的TMPRSS6选择性共价可逆肽模拟抑制剂的优化

期刊:Journal of Medicinal Chemistry
影响因子:6.8
doi:10.1021/acs.jmedchem.5c01998
Guerrab, Walid; Lepage, Matthieu; Désilets, Antoine; Joushomme, Alexandre; Desgagné, Michael; Froehlich, Ulrike; Leduc, Richard; Boudreault, Pierre-Luc
发表日期：2025
文献求助 收藏