日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Structural and functional characterization of TgGSK3, a druggable kinase in Toxoplasma gondii

弓形虫中可成药激酶TgGSK3的结构和功能表征

Diaz-Martin, Silvia; Swale, Christopher; Bellini, Valeria; Dobrescu, Irina; Wenker, Janine; Brenier-Pinchart, Marie-Pierre; Braun, Laurence; Tollec, Alwéna; Corrao, Charlotte; Couté, Yohann; Mas, Caroline; Laurent, Fabrice; Bowler, Matthew; Hakimi, Mohamed-Ali; Bougdour, Alexandre

Uncovering biomarkers for chronic toxoplasmosis detection highlights alternative pathways shaping parasite dormancy.

发现用于检测慢性弓形虫病的生物标志物,揭示了影响寄生虫休眠的替代途径

Robert Marie G, Swale Christopher, Pachano Belen, Dépéry Léa, Bellini Valeria, Dard Céline, Cannella Dominique, Corrao Charlotte, Belmudes Lucid, Couté Yohann, Bougdour Alexandre, Pelloux Hervé, Chapey Emmanuelle, Wallon Martine, Brenier-Pinchart Marie-Pierre, Hakimi Mohamed-Ali

In vitro production of cat-restricted Toxoplasma pre-sexual stages

体外生产猫限制性弓形虫性前阶段

Ana Vera Antunes #, Martina Shahinas #, Christopher Swale #, Dayana C Farhat, Chandra Ramakrishnan, Christophe Bruley, Dominique Cannella, Marie G Robert, Charlotte Corrao, Yohann Couté, Adrian B Hehl, Alexandre Bougdour, Isabelle Coppens, Mohamed-Ali Hakimi

Targeting prolyl-tRNA synthetase via a series of ATP-mimetics to accelerate drug discovery against toxoplasmosis

通过一系列ATP类似物靶向脯氨酰tRNA合成酶,加速弓形虫病药物的发现

Yogavel, Manickam; Bougdour, Alexandre; Mishra, Siddhartha; Malhotra, Nipun; Chhibber-Goel, Jyoti; Bellini, Valeria; Harlos, Karl; Laleu, Benoît; Hakimi, Mohamed-Ali; Sharma, Amit

The Toxoplasma effector GRA28 promotes parasite dissemination by inducing dendritic cell-like migratory properties in infected macrophages

弓形虫效应蛋白GRA28通过诱导受感染巨噬细胞产生类似树突状细胞的迁移特性来促进寄生虫的扩散。

Arne L Ten Hoeve ,Laurence Braun ,Matias E Rodriguez ,Gabriela C Olivera ,Alexandre Bougdour ,Lucid Belmudes ,Yohann Couté ,Jeroen P J Saeij ,Mohamed-Ali Hakimi ,Antonio Barragan

Double drugging of prolyl-tRNA synthetase provides a new paradigm for anti-infective drug development

双重药物靶向脯氨酰tRNA合成酶为抗感染药物研发提供了一种新的范式。

Manickam, Yogavel; Malhotra, Nipun; Mishra, Siddhartha; Babbar, Palak; Dusane, Abhishek; Laleu, Benoît; Bellini, Valeria; Hakimi, Mohamed-Ali; Bougdour, Alexandre; Sharma, Amit

A plant-like mechanism coupling m6A reading to polyadenylation safeguards transcriptome integrity and developmental gene partitioning in Toxoplasma

一种将 m6A 读取与多聚腺苷酸化相结合的类似植物的机制可保障弓形虫的转录组完整性和发育基因分区

Dayana C Farhat, Matthew W Bowler, Guillaume Communie, Dominique Pontier, Lucid Belmudes, Caroline Mas, Charlotte Corrao, Yohann Couté, Alexandre Bougdour, Thierry Lagrange, Mohamed-Ali Hakimi #, Christopher Swale #

ATAD2 controls chromatin-bound HIRA turnover

ATAD2 控制染色质结合的 HIRA 周转

Tao Wang, Daniel Perazza, Fayçal Boussouar, Matteo Cattaneo, Alexandre Bougdour, Florent Chuffart, Sophie Barral, Alexandra Vargas, Ariadni Liakopoulou, Denis Puthier, Lisa Bargier, Yuichi Morozumi, Mahya Jamshidikia, Isabel Garcia-Saez, Carlo Petosa, Sophie Rousseaux, André Verdel, Saadi Khochbin

The Toxoplasma effector TEEGR promotes parasite persistence by modulating NF-κB signalling via EZH2

弓形虫效应分子 TEEGR 通过 EZH2 调节 NF-κB 信号传导,促进寄生虫持续存在

Laurence Braun, Marie-Pierre Brenier-Pinchart, Pierre-Mehdi Hammoudi, Dominique Cannella, Sylvie Kieffer-Jaquinod, Julien Vollaire, Véronique Josserand, Bastien Touquet, Yohann Couté, Isabelle Tardieux, Alexandre Bougdour, Mohamed-Ali Hakimi

Characterization of a Toxoplasma effector uncovers an alternative GSK3/β-catenin-regulatory pathway of inflammation

弓形虫效应子的表征揭示了炎症的替代 GSK3/β-catenin 调节途径

Huan He, Marie-Pierre Brenier-Pinchart, Laurence Braun, Alexandra Kraut, Bastien Touquet, Yohann Couté, Isabelle Tardieux, Mohamed-Ali Hakimi, Alexandre Bougdour