日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases

发现TLR7/8拮抗剂MHV370用于治疗系统性自身免疫性疾病

Alper, Phil; Betschart, Claudia; André, Cédric; Boulay, Thomas; Cheng, Dai; Deane, Jonathan; Faller, Michael; Feifel, Roland; Glatthar, Ralf; Han, Dong; Hemmig, Rene; Jiang, Tao; Knoepfel, Thomas; Maginnis, Jillian; Mutnick, Daniel; Pei, Wei; Ruzzante, Giulia; Syka, Peter; Zhang, Guobao; Zhang, Yi; Zink, Florence; Zipfel, Géraldine; Hawtin, Stuart; Junt, Tobias; Michellys, Pierre-Yves

Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist

基于结构的TLR8结合筛选先导化合物结构优化,得到体内有效的TLR7/8拮抗剂

Betschart, Claudia; Faller, Michael; Zink, Florence; Hemmig, René; Blank, Jutta; Vangrevelinghe, Eric; Bourrel, Marjorie; Glatthar, Ralf; Behnke, Dirk; Barker, Kerstin; Heizmann, Andreas; Angst, Daniela; Nimsgern, Pierre; Jacquier, Sébastien; Junt, Tobias; Zipfel, Géraldine; Ruzzante, Giulia; Loetscher, Pius; Limonta, Sarah; Hawtin, Stuart; Andre, Cedric Bernard; Boulay, Thomas; Feifel, Roland; Knoepfel, Thomas

Donor T-cell alloreactivity against host thymic epithelium limits T-cell development after bone marrow transplantation.

供体 T 细胞对宿主胸腺上皮的同种异体反应限制了骨髓移植后 T 细胞的发育

Hauri-Hohl Mathias M, Keller Marcel P, Gill Jason, Hafen Katrin, Pachlatko Esther, Boulay Thomas, Peter Annick, Holländer Georg A, Krenger Werner

The MTE, a new core promoter element for transcription by RNA polymerase II

MTE是RNA聚合酶II转录的一个新的核心启动子元件。

Lim, Chin Yan; Santoso, Buyung; Boulay, Thomas; Dong, Emily; Ohler, Uwe; Kadonaga, James T