日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk

MC4R 缺乏引起的肥胖与胆固醇、甘油三酯水平降低以及心血管疾病风险降低有关。

Zorn, Stefanie; Bounds, Rebecca; Williamson, Alice; Lawler, Katherine; Hanssen, Ruth; Keogh, Julia; Henning, Elana; Smith, Miriam; Fielding, Barbara A; Umpleby, A Margot; Yasmeen, Summaira; Marti-Solano, Maria; Langenberg, Claudia; Wabitsch, Martin; Collet, Tinh-Hai; Farooqi, I Sadaf

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans

犬类全基因组关联研究发现 DENND1B 是犬类和人类的肥胖基因。

Wallis, Natalie J; McClellan, Alyce; Mörseburg, Alexander; Kentistou, Katherine A; Jamaluddin, Aqfan; Dowsett, Georgina K C; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y H; Sumanasekera, Natasha T; Chan, Justine; Kumar, Sambhavi S; Zhang, Rey M; Wainwright, Jodie F; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I Sadaf; Ong, Ken K; Yeo, Giles S H; Tadross, John A; Perry, John R B; Gorvin, Caroline M; Raffan, Eleanor

Structures of human protein tyrosine phosphatase variants reveal targetable allosteric sites.

人类蛋白酪氨酸磷酸酶变体的结构揭示了可靶向的变构位点。

Perdikari Aliki, Woods Virgil A, Ebrahim Ali, Lawler Katherine, Bounds Rebecca, Shah Dinesh S, Singh Nathanael I, Mehlman Tamar Skaist, Riley Blake T, Sharma Shivani, Morris Jackson W, Keogh Julia M, Henning Elana, Smith Miriam, Farooqi I Sadaf, Keedy Daniel A

Structures of human PTP1B variants reveal allosteric sites to target for weight loss therapy.

人类 PTP1B 变体的结构揭示了可作为减肥疗法靶点的变构位点

Perdikari Aliki, Woods Virgil A, Ebrahim Ali, Lawler Katherine, Bounds Rebecca, Singh Nathanael I, Mehlman Tamar Skaist, Riley Blake T, Sharma Shivani, Morris Jackson W, Keogh Julia M, Henning Elana, Smith Miriam, Farooqi I Sadaf, Keedy Daniel A

Chromosomal deletions on 16p11.2 encompassing SH2B1 are associated with accelerated metabolic disease

包含SH2B1基因的16p11.2染色体缺失与代谢性疾病加速进展相关。

Hanssen, Ruth; Auwerx, Chiara; Jõeloo, Maarja; Sadler, Marie C; Henning, Elana; Keogh, Julia; Bounds, Rebecca; Smith, Miriam; Firth, Helen V; Kutalik, Zoltán; Farooqi, I Sadaf; Reymond, Alexandre; Lawler, Katherine

Obesity Due to Steroid Receptor Coactivator-1 Deficiency Is Associated With Endocrine and Metabolic Abnormalities

类固醇受体共激活因子-1缺乏引起的肥胖与内分泌和代谢异常有关

Cacciottolo, Tessa M; Henning, Elana; Keogh, Julia M; Bel Lassen, Pierre; Lawler, Katherine; Bounds, Rebecca; Ahmed, Rachel; Perdikari, Aliki; Mendes de Oliveira, Edson; Smith, Miriam; Godfrey, Edmund M; Johnson, Elspeth; Hodson, Leanne; Clément, Karine; van der Klaauw, Agatha A; Farooqi, I Sadaf

Genetic architecture of human thinness compared to severe obesity

人类瘦弱与重度肥胖的遗传结构比较

Riveros-McKay, Fernando; Mistry, Vanisha; Bounds, Rebecca; Hendricks, Audrey; Keogh, Julia M; Thomas, Hannah; Henning, Elana; Corbin, Laura J; O'Rahilly, Stephen; Zeggini, Eleftheria; Wheeler, Eleanor; Barroso, Inês; Farooqi, I Sadaf

Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity

对患有严重儿童期肥胖症的个体进行人类和啮齿动物肥胖基因罕见变异分析

Hendricks, Audrey E; Bochukova, Elena G; Marenne, Gaëlle; Keogh, Julia M; Atanassova, Neli; Bounds, Rebecca; Wheeler, Eleanor; Mistry, Vanisha; Henning, Elana; Körner, Antje; Muddyman, Dawn; McCarthy, Shane; Hinney, Anke; Hebebrand, Johannes; Scott, Robert A; Langenberg, Claudia; Wareham, Nick J; Surendran, Praveen; Howson, Joanna M; Butterworth, Adam S; Danesh, John; Nordestgaard, Børge G; Nielsen, Sune F; Afzal, Shoaib; Papadia, Sofia; Ashford, Sofie; Garg, Sumedha; Millhauser, Glenn L; Palomino, Rafael I; Kwasniewska, Alexandra; Tachmazidou, Ioanna; O'Rahilly, Stephen; Zeggini, Eleftheria; Barroso, Inês; Farooqi, I Sadaf

KSR2 mutations are associated with obesity, insulin resistance, and impaired cellular fuel oxidation.

KSR2 突变与肥胖、胰岛素抵抗和细胞燃料氧化受损有关

Pearce Laura R, Atanassova Neli, Banton Matthew C, Bottomley Bill, van der Klaauw Agatha A, Revelli Jean-Pierre, Hendricks Audrey, Keogh Julia M, Henning Elana, Doree Deon, Jeter-Jones Sabrina, Garg Sumedha, Bochukova Elena G, Bounds Rebecca, Ashford Sofie, Gayton Emma, Hindmarsh Peter C, Shield Julian P H, Crowne Elizabeth, Barford David, Wareham Nick J, O'Rahilly Stephen, Murphy Michael P, Powell David R, Barroso Ines, Farooqi I Sadaf