日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Drug Repurposing: Conversion of the Peripherally Restricted HIV Protease Inhibitor Amprenavir to Potent, Selective, and CNS-Penetrant Agonists for the Cannabinoid Receptor 2

药物再利用:将外周限制性 HIV 蛋白酶抑制剂安普那韦转化为强效、选择性强且能穿透血脑屏障的大麻素受体 2 激动剂

Haymer, Daniel H; Duncan, Renn A; Rodriguez, Alice L; Han, Allie; Lindsay, Richard J; Wijesiri, N Kithmini; Thompson Gray, Analisa; Krishnan, Srinivasan; Qi, Aidong; Brown, Benjamin P; Boutaud, Olivier; Engers, Darren W; Jones, Carrie K; Niswender, Colleen M; Lindsley, Craig W; Bender, Aaron M

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy

VU6025733 (AG06827) 的发现:一种高选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM),具有强大的体内疗效

Gregro, Alison R; Park, Charlotte; Long, Madeline F; Baker, Logan A; Bollinger, Katrina A; Ringuette, Anna E; Peng, Li; Luscombe, Vincent B; Billard, Natasha B; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Dickerson, Jonathan W; Rook, Jerri M; O'Neill, Jordan; Chang, Sichen; Boonen, Harrie C M; Jensen, Thomas; Thomsen, Morten S; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Discovery of 7-(Pyridin-3-yl)thieno[3,2-b]pyridine-5-carboxamides as Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

发现 7-(吡啶-3-基)噻吩并[3,2-b]吡啶-5-甲酰胺类化合物作为代谢型谷氨酸受体5亚型的负变构调节剂

Henderson, Scott H; Ringuette, Anna E; Whomble, David L; Capstick, Rory A; Richardson, Alexa E; Maurer, Mallory A; Billard, Natasha B; Lei, Xia; Wilkinson, Joshua C; Kethanapalli, Sri H; Cho, Hyekyung P; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Rook, Jerri M; Chang, Sichen; Blobaum, Anna L; Boutaud, Olivier; Felts, Andrew S; Conn, P Jeffrey; Lindsley, Craig W; Temple, Kayla J

Discovery of VU6083859, a TAOK1 Selective Inhibitor, and VU6080195, a pan-TAOK Activator

发现 VU6083859(一种 TAOK1 选择性抑制剂)和 VU6080195(一种泛 TAOK 激活剂)

Schultz, Daniel C; Parr, Lauren C; Sweet, Hunter; Lamb, Sean; Engers, Julie L; Napier, Nathaniel C; McKinnie, Hallie G; Whomble, David; Kramlinger, Valerie; Boutaud, Olivier; Lindsley, Craig W

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

TMEM17第二个跨膜结构域的错义变异会破坏其稳定性和功能,并导致广泛的纤毛病表型谱。

Boutaud, Lucile; Li, Chunmei; Moncler, Candice; Verlin, Laure; Garfa-Traoré, Meriem; Bourgon, Nicolas; Akbari, Dhruvin; Porée, Jeanne; Serpieri, Valentina; Panza, Marine; Haddad, Lynda; Nitschké, Patrick; Aziza, Jacqueline; Matt, Cristina; Valente, Enza Maria; Gargallo, Patricia; Dubucs, Charlotte; Attié-Bitach, Tania; Leroux, Michel R; Thomas, Sophie

Protective role of epithelial deoxyhypusine synthase in colorectal carcinogenesis caused by deletion of the adenomatous polyposis coli gene

上皮脱氧次黄嘌呤合成酶在腺瘤性息肉病基因缺失引起的结直肠癌发生中的保护作用

Gobert, Alain P; Hawkins, Caroline V; Snyder, Lydia A; Williams, Kamery J; Barry, Daniel P; Allaman, Margaret M; Asim, Mohammad; McNamara, Kara M; Carey, Shane M; Delgado, Alberto G; Tyree, Regina N; Rose, Kristie L; Wang, Yu; Zhao, Shilin; Boutaud, Olivier; Zagol-Ikapitte, Irène; Piazuelo, M Blanca; Washington, M Kay; Coburn, Lori A; Wilson, Keith T

Chronic Gastroesophageal Reflux Dysregulates Proteostasis in Esophageal Epithelial Cells.

慢性胃食管反流会扰乱食管上皮细胞的蛋白质稳态

Paulrasu Kodisundaram, Caspa Gokulan Ravindran, El-Rifai Wael, Chen Zhibin, Que Jianwen, Wang Timothy C, Boutaud Olivier G, Briegel Karoline, Dikalov Sergey I, Garcia-Buitrago Monica T, Zaika Alexander I

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)

选择性和中枢神经系统渗透性炔基TREK抑制剂的优化:ONO-9517601 (VU6022856) 和 ONO-7927846 (VU6024391) 的发现和表征

Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S; Bollinger, Sean; Schmitt, Joza A; Chopko, Trevor C; Garrison, Aaron T; Perry, Charles K; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J; Dickerson, Jonathan W; Bubser, Michael; Rook, Jerri M; Jones, Carrie K; Boutaud, Olivier; Bridges, Thomas M; Denton, Jerod S; Engers, Darren W; Kurata, Haruto; Lindsley, Craig W

Complete loss of IFT27 function leads to a phenotypic spectrum of fetal lethal ciliopathy associated with altered ciliogenesis

IFT27功能的完全丧失会导致一系列与纤毛发生异常相关的胎儿致死性纤毛病表型。

Haïm, David; Roux, Nathalie; Boutaud, Lucile; Verlin, Laure; Quélin, Chloé; Moncler, Candice; Bourgon, Nicolas; Achaiia, Amale; Roth, Philippe; Marijon, Pierre; Vanlieferinghen, Sarah; Thomas, Sophie; Attié-Bitach, Tania

Discovery of Thieno[3,2-b]pyridine-5-carboxamide and 2,3-Difluorobenzamide Negative Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5

噻吩并[3,2-b]吡啶-5-甲酰胺和2,3-二氟苯甲酰胺作为代谢型谷氨酸受体5亚型的负变构调节剂的发现

Crocker, Katherine E; Henderson, Scott H; Capstick, Rory A; Whomble, David L; Bender, Aaron M; Felts, Andrew S; Han, Changho; Engers, Julie L; Billard, Natasha B; Maurer, Mallory A; Cho, Hyekyung P; Rodriguez, Alice L; Niswender, Colleen M; O'Neill, Jordan; Watson, Katherine J; Chang, Sichen; Blobaum, Anna L; Boutaud, Olivier; Peng, Weimin; Rook, Jerri M; Conn, P Jeffrey; Lindsley, Craig W; Temple, Kayla J