日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

ADT-1004: a first-in-class, oral pan-RAS inhibitor with robust antitumor activity in preclinical models of pancreatic ductal adenocarcinoma

ADT-1004:一种首创的口服泛RAS抑制剂,在胰腺导管腺癌的临床前模型中具有强大的抗肿瘤活性

Bandi, Dhana Sekhar Reddy; Nagaraju, Ganji Purnachandra; Sarvesh, Sujith; Carstens, Julienne L; Foote, Jeremy B; Graff, Emily C; Fang, Yu-Hua D; Keeton, Adam B; Chen, Xi; Valiyaveettil, Jacob; Berry, Kristy L; Bae, Sejong; Akce, Mehmet; Gorman, Greg; Yoon, Karina J; Manne, Upender; Boyd, Michael R; Buchsbaum, Donald J; Azmi, Asfar S; Maxuitenko, Yulia Y; Piazza, Gary A; El-Rayes, Bassel F

A Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth and Induces Antitumor Immunity in Gastrointestinal Cancer.

一种具有独特作用机制的泛 RAS 抑制剂可抑制肿瘤生长并诱导胃肠道癌症的抗肿瘤免疫

Foote Jeremy B, Mattox Tyler E, Keeton Adam B, Chen Xi, Smith Forrest T, Berry Kristy, Holmes Thomas W, Wang Junwei, Huang Chung-Hui, Ward Antonio, Mitra Amit K, Ramirez-Alcantara Veronica, Hardy Cherlene, Fleten Karianne G, Flatmark Kjersti, Yoon Karina J, Sarvesh Sujith, Nagaraju Ganji P, Bandi Dhana Sekhar Reddy, Maxuitenko Yulia Y, Valiyaveettil Jacob, Carstens Julienne L, Buchsbaum Donald J, Yang Jennifer, Zhou Gang, Nurmemmedov Elmar, Babic Ivan, Gaponeko Vadim, Abdelkarim Hazem, Boyd Michael R, Gorman Greg, Manne Upender, Bae Sejong, El-Rayes Bassel F, Piazza Gary A

A Novel Pan-RAS Inhibitor with a Unique Mechanism of Action Blocks Tumor Growth in Mouse Models of GI Cancer

一种具有独特作用机制的新型泛RAS抑制剂可抑制小鼠胃肠道癌症模型中的肿瘤生长

Foote, Jeremy B; Mattox, Tyler E; Keeton, Adam B; Chen, Xi; Smith, Forrest; Berry, Kristy L; Holmes, Thomas; Wang, Junwei; Huang, Chung-Hui; Ward, Antonio B; Mitra, Amit K; Ramirez-Alcantara, Veronica; Hardy, Cherlene; Fleten, Karrianne G; Flatmark, Kjersti; Yoon, Karina J; Sarvesh, Sujith; Nagaraju, Ganji Purnachandra; Bandi, Dhana Sekhar Reddy; Maxuitenko, Yulia Y; Valiyaveettil, Jacob; Carstens, Julienne L; Buchsbaum, Donald J; Yang, Jennifer; Zhou, Gang; Nurmemmedov, Elmar; Babic, Ivan; Gaponenko, Vadim; Abdelkarim, Hazem; Boyd, Michael R; Gorman, Gregory S; Manne, Upender; Bae, Sejong; El-Rayes, Bassel F; Piazza, Gary A

PDE5 and PDE10 inhibition activates cGMP/PKG signaling to block Wnt/β-catenin transcription, cancer cell growth, and tumor immunity

PDE5 和 PDE10 抑制剂可激活 cGMP/PKG 信号通路,从而阻断 Wnt/β-catenin 转录、癌细胞生长和肿瘤免疫。

Piazza, Gary A; Ward, Antonio; Chen, Xi; Maxuitenko, Yulia; Coley, Alex; Aboelella, Nada S; Buchsbaum, Donald J; Boyd, Michael R; Keeton, Adam B; Zhou, Gang

Thioltransferase (glutaredoxin) mediates recovery of motor neurons from excitotoxic mitochondrial injury

硫醇转移酶(谷胱甘肽还原酶)介导运动神经元从兴奋性毒性线粒体损伤中恢复。

Kenchappa, Rajappa S; Diwakar, Latha; Boyd, Michael R; Ravindranath, Vijayalakshmi