日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Molecular features of human pathological tau distinguish tauopathy-associated dementias

人类病理性tau蛋白的分子特征可以区分tau蛋白病相关的痴呆症

Kumar, Mukesh; Schlaffner, Christoph N; Tang, Shaojun; Beuvink, Maaike A; Viode, Arthur; Mair, Waltraud; Jha, Meenakshi; Uncu, Ceren; Wesseling, Hendrik; Wang, Tian; Oakley, Derek H; Beerepoot, Pieter; Xue, Jie; Connors, Theresa R; Davis, David A; Frosch, Matthew P; Murray, Melissa E; Spina, Salvatore E; Grinberg, Lea T; Seeley, William W; Miller, Bruce L; Boxer, Adam L; Geschwind, Daniel H; Kosik, Kenneth S; Dickson, Dennis W; Renard, Bernhard Y; DeTure, Michael; McKee, Ann C; Hyman, Bradley T; Steen, Hanno; Steen, Judith A

Structural heterogeneity and substrate engagement mechanism of the bacterial proteasome activator Bpa

细菌蛋白酶体激活剂Bpa的结构异质性和底物结合机制

Davis, Bradley T V; Rennella, Enrico; Haris, Anisha; Ujma, Jakub; Bruton, David; Richardson, Keith; Giles, Kevin; Kay, Lewis E; Vahidi, Siavash

Alzheimer's disease pathology degrades an NMDA receptor-dependent spontaneous activity pattern in cortico-hippocampal circuits.

阿尔茨海默病病理会破坏皮质-海马回路中 NMDA 受体依赖的自发活动模式。

Ellingford Robert, Harris Samuel S, Kehring Marten, Rajani Rikesh M, Lam Francesca Kar Wey, Graykowski David, BÓ§ken Dorothea, Welikovitch Lindsay A, Khasnavis Anita, Laban Rhiannon, Heslegrave Amanda, Yaman Umran, Mate de Gerando Anastasie, Bond Suraya A, Wray Selina, Salih Dervis A, Dupret David, Dolan Raymond J, Klenerman David, Zetterberg Henrik, Hyman Bradley T, Busche Marc Aurel

Progressive neuroinflammation and deficits in motor function in a mouse model with an Epg5 pathogenic variant of Vici syndrome

在携带Vici综合征Epg5致病变异的小鼠模型中,出现进行性神经炎症和运动功能障碍。

Thornton, Bradley T; Hardinger, Alexandra G; Pence, Laramie; Kumar, Priyanka Prem; Connolly, Nikolas; Weir, Scott J; Vivian, Jay L

Brain volume trajectories in Down syndrome and autosomal dominant Alzheimer's disease

唐氏综合征和常染色体显性遗传阿尔茨海默病患者的脑容量变化轨迹

Kennedy, James T; Wisch, Julie K; Boerwinkle, Anna H; Millar, Peter R; McKay, Nicole S; Brickman, Adam M; Chhatwal, Jasmeer P; Mendez, Patricio Chrem; Christian, Bradley T; Cohen, Anne; Cruchaga, Carlos; Daniels, Alisha; Flores, Shaney; Handen, Benjamin L; Hartley, Sigan L; Head, Elizabeth; Ibanez, Laura; Krisnsky-McHale, Sharon J; la Fougere, Christian; Lai, Florence; Laymon, Charles M; Lee, Joseph H; Lee, Jae-Hong; Levin, Johannes; Llibre-Guerra, Jorge; Aguillon, David F; Lott, Ira T; Mapstone, Mark; McDade, Eric; Morris, John; O'Bryant, Sid E; Price, Julie C; Rafii, Michael S; Roh, Jee Hoon; Rosas, H Diana; Schupf, Nicole; Supnet-Bell, Charlene; Xiong, Chengjie; Zaman, Shahid; Benzinger, Tammie L S; Gordon, Brian A; Ances, Beau M

Non-cell-autonomous tumor promotion in DICER1 cancer predisposition

DICER1癌症易感性中的非细胞自主性肿瘤促进作用

Randolph K Larsen th,Jason A Hanna,Hongjian Jin,Kristin B Reed,Darden W Kimbrough,Kyna Vuong,Jongchan Hwang,Grace E Adkins,Jack D Hopkins,Bradley T Stevens,Myron K Evans nd,Casey G Langdon,Catherine J Drummond,Matthew R Garcia,Kristin B Wiggins,Amy R Iverson,David Finkelstein,Patrick A Schreiner,Jason W Rosch,Jerold E Rehg,Kris Ann P Schultz,Mark E Hatley

Prenatal Stress and Prenatal Alcohol Alter the Adult Dopamine System and Alcohol Consumption: Dopamine Drives Drinking Behavior in a Prospective 20-Year Longitudinal Experiment with Rhesus Macaques

产前压力和产前饮酒会改变成年后的多巴胺系统和酒精摄入量:一项针对恒河猴的前瞻性20年纵向实验表明,多巴胺驱动饮酒行为

Converse, Alexander K; Ahlers, Elizabeth O; Barnhart, Todd E; Christian, Bradley T; DeJesus, Onofre T; Engle, Jonathan W; Holden, James E; Larson, Julie A; Moirano, Jeffrey M; Murali, Dhanabalan; Nickles, Robert J; Resch, Leslie M; Moore, Colleen F; Schneider, Mary L

Seed-competent tau oligomers' activity correlates with the rate of progression in sporadic Alzheimer's disease patients

具有种子形成能力的tau寡聚体的活性与散发性阿尔茨海默病患者的疾病进展速度相关

Perbet, Romain; Wiedmer, Anne E; Quitot, Noe; Bhavsar, Harshil; Perrin, Florian; Gaona, Angelica; Mate de Gerando, Anastasie; Gomez Isla, Theresa; Frosch, Matthew P; Das, Sudeshna; Hyman, Bradley T

Alzheimer's disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons.

阿尔茨海默病患者体内产生的高分子量 tau 蛋白会损害海马神经元的爆发性放电

Harris Samuel S, Ellingford Robert, Hartmann Jana, Dasgupta Debanjan, Kehring Marten, Rajani Rikesh M, Graykowski David, Quittot Noé, Sivasankaran Dhanush, Commins Caitlin, Fan Zhanyun, Bond Suraya A, Wolf Fred, Dupret David, Dolan Raymond J, Konnerth Arthur, Neef Andreas, Hyman Bradley T, Busche Marc Aurel

Genetic variation at 11q23.1 confers colorectal cancer risk by dysregulation of colonic tuft cell transcriptional activator POU2AF2.

11q23.1 的基因变异通过结肠簇状细胞转录激活因子 POU2AF2 的失调而增加结直肠癌的风险

Rajasekaran Vidya, Harris Bradley T, Osborn Ruby T, Smillie Claire, Donnelly Kevin, Bacou Marion, Esiri-Bloom Edward, Ooi Li-Yin, Allan Morven, Walker Marion, Reid Stuart, Meynert Alison, Grimes Graeme, Blackmur James P, Vaughan-Shaw Peter G, Law Philip J, Fernández-Rozadilla Ceres, Tomlinson Ian, Houlston Richard S, Myant Kevin B, Din Farhat Vn, Timofeeva Maria, Dunlop Malcolm G, Farrington Susan M