CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity
利用 CRISPR/Cas9 技术在人类 iPSC 衍生的皮层神经元中进行筛选,发现 NEK6 是 C9orf72 poly(PR) 毒性的新型疾病修饰因子。
期刊:Alzheimers & Dementia
影响因子:11.1
doi:10.1002/alz.12760
Guo, Wenting; Wang, Haibo; Kumar Tharkeshwar, Arun; Couthouis, Julien; Braems, Elke; Masrori, Pegah; Van Schoor, Evelien; Fan, Yannan; Ahuja, Karan; Moisse, Matthieu; Jacquemyn, Maarten; Furtado Madeiro da Costa, Rodrigo; Gajjar, Madhavsai; Balusu, Sriram; Tricot, Tine; Fumagalli, Laura; Hersmus, Nicole; Janky, Rekin's; Impens, Francis; Vanden Berghe, Pieter; Ho, Ritchie; Thal, Dietmar Rudolf; Vandenberghe, Rik; Hegde, Muralidhar L; Chandran, Siddharthan; De Strooper, Bart; Daelemans, Dirk; Van Damme, Philip; Van Den Bosch, Ludo; Verfaillie, Catherine