日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Selective inhibitors of the TrkC.T1 receptor reduce retinal inflammation and delay neuronal death in a model of retinitis pigmentosa.

TrkC.T1 受体的选择性抑制剂可减轻视网膜色素变性模型中的视网膜炎症并延缓神经元死亡

Brahimi Fouad, Nassour Hassan, Galan Alba, Guruswamy Revathy, Ortiz Christina, Nejatie Ali, Nedev Hinyu, Trempe Jean-Francois, Saragovi H Uri

Alternative Splicing of a Receptor Intracellular Domain Yields Different Ectodomain Conformations, Enabling Isoform-Selective Functional Ligands

受体胞内结构域的选择性剪接产生不同的胞外结构域构象,从而实现异构体选择性功能配体。

Brahimi, Fouad; Galan, Alba; Jmaeff, Sean; Barcelona, Pablo F; De Jay, Nicolas; Dejgaard, Kurt; Young, Jason C; Kleinman, Claudia L; Thomas, David Y; Saragovi, H Uri

Rapid High-Yield Production of Functional SARS-CoV-2 Receptor Binding Domain by Viral and Non-Viral Transient Expression for Pre-Clinical Evaluation.

利用病毒和非病毒瞬时表达快速高产生产功能性SARS-CoV-2受体结合域,用于临床前评估

Farnós Omar, Venereo-Sánchez Alina, Xu Xingge, Chan Cindy, Dash Shantoshini, Chaabane Hanan, Sauvageau Janelle, Brahimi Fouad, Saragovi Uri, Leclerc Denis, Kamen Amine A

In retinitis pigmentosa TrkC.T1-dependent vectorial Erk activity upregulates glial TNF-α, causing selective neuronal death

在视网膜色素变性中,TrkC.T1依赖的Erk矢量活性上调神经胶质细胞TNF-α,导致选择性神经元死亡。

Galán, Alba; Jmaeff, Sean; Barcelona, Pablo F; Brahimi, Fouad; Sarunic, Marinko V; Saragovi, H Uri

Bivalent diketopiperazine-based tropomysin receptor kinase C (TrkC) antagonists

基于二酮哌嗪的二价原肌球蛋白受体激酶C (TrkC) 拮抗剂

Liu, Jing; Brahimi, Fouad; Saragovi, H Uri; Burgess, Kevin

Bivalent peptidomimetic ligands of TrkC are biased agonists and selectively induce neuritogenesis or potentiate neurotrophin-3 trophic signals

TrkC的二价肽模拟配体是偏向性激动剂,可选择性地诱导神经突生成或增强神经营养因子-3的营养信号。

Chen, Dianjun; Brahimi, Fouad; Angell, Yu; Li, Yu-Chin; Moscowicz, Jennifer; Saragovi, H Uri; Burgess, Kevin