Early expression of mature αβ TCR in CD4(-)CD8(-) T cell progenitors enables MHC to drive development of T-ALL bearing NOTCH mutations
CD4(-)CD8(-) T 细胞祖细胞中成熟 αβ TCR 的早期表达使 MHC 能够驱动携带 NOTCH 突变的 T 细胞急性淋巴细胞白血病 (T-ALL) 的发展。
期刊:Proceedings of the National Academy of Sciences of the United States of America
影响因子:9.1
doi:10.1073/pnas.2118529119
Laffey, Kimberly G; Stiles, Robert J; Ludescher, Melissa J; Davis, Tessa R; Khwaja, Shariq S; Bram, Richard J; Wettstein, Peter J; Ramachandran, Venkataraman; Parks, Christopher A; Reyes, Edwin E; Ferrer, Alejandro; Canfield, Jenna M; Johnson, Cory E; Hammer, Richard D; Gil, Diana; Schrum, Adam G
T细胞
OTC
NOTCH
CD8
白血病
细胞生物学
CD4
