日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

A Therapeutic Small-Interfering RNA Potentiates Janus Kinase 1 Modulation for the Treatment of Dog Inflammatory Diseases.

治疗性小干扰RNA增强Janus激酶1调节作用,用于治疗犬类炎症性疾病

Tang Qi, Fakih Hassan H, Gross Katherine Y, Winter Sarah J, Bramato Brianna M, Yıldız-Altay Ümmügülsüm, Chang Benjamin K, Echeverria Dimas, Jackson Samuel O, McHugh Nicholas, Srnka Alyxandr, Alterman Julia F, Almela Ramón M, Kudej Raymond K, London Cheryl A, Richmond Jillian M, Harris John E, Khvorova Anastasia

Albumin-binding dendrimer-conjugated siRNA enables safe and effective gene silencing throughout the central nervous system

白蛋白结合树状聚合物偶联的siRNA能够安全有效地在整个中枢神经系统中进行基因沉默。

Fakih, Hassan H; Ohara, Masahiro; Summers, Ashley; Sarli, Samantha L; Kelly, Karen; Gagnon, Rosemary; Maru, Bruktawit; Bramato, Brianna; Khvorova, Anastasia; Watts, Jonathan K

Blocking somatic repeat expansion and lowering huntingtin via RNA interference synergize to prevent Huntington's disease pathogenesis in mice

通过RNA干扰抑制体细胞重复序列扩增和降低亨廷顿蛋白水平可协同预防小鼠亨廷顿病的发病机制。

Belgrad, Jillian; Summers, Ashley; Landles, Christian; Greene, Jonathan R; Hildebrand, Samuel; Knox, Emily; Sapp, Ellen; Yamada, Nozomi; Furgal, Raymond; Miller, Rachael; Osborne, Georgina F; Chase, Kathryn; Luu, Eric; Freedman, Jason; Bramato, Brianna; McHugh, Nicholas; Benoit, Vicky; O'Reilly, Daniel; Greer, Paul; Bates, Gillian P; Vogt, Thomas F; Lee, Ramee; Howland, David; DiFiglia, Marian; Aronin, Neil; Khvorova, Anastasia

Agri-environmental policies from 1960 to 2022

1960年至2022年的农业环境政策

Wuepper, David; Wiebecke, Ilsabe; Meier, Lara; Vogelsanger, Sarah; Bramato, Selina; Fürholz, Andrea; Finger, Robert

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system.

可编程双靶向siRNA支架支持中枢神经系统中有效的双基因调控

Belgrad Jillian, Tang Qi, Hildebrand Sam, Summers Ashley, Sapp Ellen, Echeverria Dimas, O'Reilly Dan, Luu Eric, Bramato Brianna, Allen Sarah, Cooper David, Alterman Julia, Yamada Ken, Aronin Neil, DiFiglia Marian, Khvorova Anastasia

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs

鉴定选择性和非选择性靶向C9ORF72的体内活性siRNA

Gilbert, James W; Kennedy, Zachary; Godinho, Bruno M D C; Summers, Ashley; Weiss, Alexandra; Echeverria, Dimas; Bramato, Brianna; McHugh, Nicholas; Cooper, David; Yamada, Ken; Hassler, Matthew; Tran, Hélène; Gao, Fen Biao; Brown, Robert H Jr; Khvorova, Anastasia

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo.

mRNA 核聚集导致 siRNA 在体内对突变亨廷顿 mRNA 和蛋白质的沉默存在差异

Allen Sarah, O'Reilly Daniel, Miller Rachael, Sapp Ellen, Summers Ashley, Paquette Joseph, Echeverria Moreno Dimas, Bramato Brianna, McHugh Nicholas, Yamada Ken, Aronin Neil, DiFiglia Marian, Khvorova Anastasia

Sarcopenia in subjects with Alzheimer's disease: prevalence and comparison of agreement between EGWSOP1, EGWSOP2, and FNIH criteria

阿尔茨海默病患者的肌少症:患病率及EGWSOP1、EGWSOP2和FNIH标准的一致性比较

Barone, Roberta; Bramato, Giulia; Gnoni, Valentina; Giugno, Alessia; Urso, Daniele; Zecca, Chiara; Nigro, Salvatore; Filardi, Marco; Logroscino, Giancarlo

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca(2+) and Mg(2+) in the formulation

在制剂中添加Ca(2+)和Mg(2+)可预防中枢神经系统治疗性寡核苷酸的急性神经毒性

Miller, Rachael; Paquette, Joseph; Barker, Alexandra; Sapp, Ellen; McHugh, Nicholas; Bramato, Brianna; Yamada, Nozomi; Alterman, Julia; Echeveria, Dimas; Yamada, Ken; Watts, Jonathan; Anaclet, Christelle; DiFiglia, Marian; Khvorova, Anastasia; Aronin, Neil

mRNA nuclear clustering leads to a difference in mutant huntingtin mRNA and protein silencing by siRNAs in vivo.

mRNA 核聚集导致突变亨廷顿 mRNA 和蛋白质在体内通过 siRNA 沉默存在差异

Allen Sarah, O'Reilly Daniel, Miller Rachael, Sapp Ellen, Summers Ashley, Paquette Joseph, Moreno Dimas Echeverria, Bramato Brianna, McHugh Nicholas, Yamada Ken, Aronin Neil, DiFiglia Marian, Khvorova Anastasia