Brandon Dale相关文献与解析，生知库 | 链接生命科学的每一步

Zhaoyu Xue ，Lihuai Qin ，Hongwen Xuan ，Kaixiu Luo ，Mengying Huang ，Ling Xie ，Yangzhou Su ，Longxia Xu ，Josiah Harsh ，Brandon Dale ，Xiaobing Shi ，Xian Chen ，H Ümit Kaniskan ，Jian Jin ，Hong Wen

白血病

ENL

肿瘤免疫

肿瘤

发表日期：2024

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Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

发现一种新型、高效 EZH2 PROTAC 降解剂，用于靶向 EZH2 的非典型致癌功能

期刊:European Journal of Medicinal Chemistry

影响因子:6

doi:10.1016/j.ejmech.2024.116154

Julia Velez, Brandon Dale, Kwang-Su Park, H Ümit Kaniskan, Xufen Yu, Jian Jin

肿瘤

发表日期：2024

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Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

通过新型蛋白质复合物降解剂策略靶向降解 PRC1 成分 BMI1 和 RING1B

期刊:Advanced Science

影响因子:

doi:10.1002/advs.202205573

Kwang-Su Park, Lihuai Qin, Md Kabir, Kaixiu Luo, Brandon Dale, Yue Zhong, Arum Kim, Gang Greg Wang, Husnu Ümit Kaniskan, Jian Jin

信号转导

发表日期：2023

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Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies

通过构效关系研究发现强效、选择性且体内有效的 AKT 激酶蛋白降解剂

期刊:Journal of Medicinal Chemistry

影响因子:6.8

doi:10.1021/acs.jmedchem.1c02165

Xufen Yu, Jia Xu, Yudao Shen, Kaitlyn M Cahuzac, Kwang-Su Park, Brandon Dale, Jing Liu, Ramon E Parsons, Jian Jin

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

通过新型蛋白水解靶向 Zeste 同源物 2 增强子的嵌合体降解剂来靶向三阴性乳腺癌

期刊:ACS Pharmacology & Translational Science

影响因子:4.9

doi:10.1021/acsptsci.2c00100

Brandon Dale, Chris Anderson, Kwang-Su Park, H Ümit Kaniskan, Anqi Ma, Yudao Shen, Chengwei Zhang, Ling Xie, Xian Chen, Xufen Yu, Jian Jin

Discovery of a first-in-class EZH2 selective degrader

发现首创的 EZH2 选择性降解剂

期刊:Nature Chemical Biology

影响因子:12.9

doi:10.1038/s41589-019-0421-4

Anqi Ma #, Elias Stratikopoulos #, Kwang-Su Park #, Jieli Wei, Tiphaine C Martin, Xiaobao Yang, Megan Schwarz, Violetta Leshchenko, Alexander Rialdi, Brandon Dale, Alessandro Lagana, Ernesto Guccione, Samir Parekh, Ramon Parsons, Jian Jin

信号转导

发表日期：2020

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American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria

美国内战植物药物可抑制耐多药细菌的生长、生物膜形成和群体感应

期刊:Scientific Reports

影响因子:3.8

doi:10.1038/s41598-019-44242-y

Micah Dettweiler, James T Lyles, Kate Nelson, Brandon Dale, Ryan M Reddinger, Daniel V Zurawski, Cassandra L Quave

微生物学

发表日期：2019

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A potent and selective ENL degrader suppresses oncogenic gene expression and leukemia progression

一种高效且选择性的ENL降解剂可抑制致癌基因表达和白血病进展。

Discovery of a novel, highly potent EZH2 PROTAC degrader for targeting non-canonical oncogenic functions of EZH2

发现一种新型、高效 EZH2 PROTAC 降解剂，用于靶向 EZH2 的非典型致癌功能

Targeted Degradation of PRC1 Components, BMI1 and RING1B, via a Novel Protein Complex Degrader Strategy

通过新型蛋白质复合物降解剂策略靶向降解 PRC1 成分 BMI1 和 RING1B

Discovery of Potent, Selective, and In Vivo Efficacious AKT Kinase Protein Degraders via Structure-Activity Relationship Studies

通过构效关系研究发现强效、选择性且体内有效的 AKT 激酶蛋白降解剂

Targeting Triple-Negative Breast Cancer by a Novel Proteolysis Targeting Chimera Degrader of Enhancer of Zeste Homolog 2

通过新型蛋白水解靶向 Zeste 同源物 2 增强子的嵌合体降解剂来靶向三阴性乳腺癌

Discovery of a first-in-class EZH2 selective degrader

发现首创的 EZH2 选择性降解剂

American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria

美国内战植物药物可抑制耐多药细菌的生长、生物膜形成和群体感应