日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Fluorescence Lifetime-Based FRET Biosensors for Monitoring N Terminal Domain-Dependent Interactions of TDP-43 in Living Cells: A Novel Approach for ALS and FTD Drug Discovery.

基于荧光寿命的 FRET 生物传感器用于监测活细胞中 TDP-43 的 N 端结构域依赖性相互作用:一种用于 ALS 和 FTD 药物发现的新方法

Nathan Kochen Noah, Murray Marguerite, Zafari Sophia, Vunnam Nagamani, Liao Elly E, Chen Lihsia, Braun Anthony R, Sachs Jonathan N

Post-translational modification sites are present in hydrophilic cavities of alpha-synuclein, tau, FUS, and TDP-43 fibrils: A molecular dynamics study

α-突触核蛋白、tau蛋白、FUS蛋白和TDP-43原纤维的亲水腔中存在翻译后修饰位点:一项分子动力学研究

Kochen, Noah Nathan; Seaney, Darren; Vasandani, Vivek; Murray, Marguerite; Braun, Anthony R; Sachs, Jonathan N

Proteasomal Stimulation by MK886 and Its Derivatives Can Rescue Tau-Induced Neurite Pathology

MK886及其衍生物对蛋白酶体的刺激可以挽救tau蛋白诱导的神经突病变

Liao, Elly E; Yang, Mu; Nathan Kochen, Noah; Vunnam, Nagamani; Braun, Anthony R; Ferguson, David M; Sachs, Jonathan N

α-Synuclein's Uniquely Long Amphipathic Helix Enhances its Membrane Binding and Remodeling Capacity

α-突触核蛋白独特的长两亲性螺旋结构增强了其膜结合和重塑能力

Braun, Anthony R; Lacy, Michael M; Ducas, Vanessa C; Rhoades, Elizabeth; Sachs, Jonathan N

Polyunsaturated chains in asymmetric lipids disorder raft mixtures and preferentially associate with α-Synuclein

不对称脂质中的多不饱和链会扰乱脂筏混合物,并优先与α-突触核蛋白结合。

Brummel, Benjamin E; Braun, Anthony R; Sachs, Jonathan N

Membrane remodeling and mechanics: Experiments and simulations of α-Synuclein

膜重塑与力学:α-突触核蛋白的实验与模拟

West, Ana; Brummel, Benjamin E; Braun, Anthony R; Rhoades, Elizabeth; Sachs, Jonathan N

α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles

α-突触核蛋白降低小单层囊泡模拟中的张力并增加其波动性

Braun, Anthony R; Sachs, Jonathan N

Determining Structural and Mechanical Properties from Molecular Dynamics Simulations of Lipid Vesicles

利用脂质囊泡的分子动力学模拟确定其结构和力学性质

Braun, Anthony R; Sachs, Jonathan N

Open and closed conformations of the isolated transmembrane domain of death receptor 5 support a new model of activation

死亡受体5分离的跨膜结构域的开放和封闭构象支持一种新的激活模型。

Lewis, Andrew K; James, Zachary M; McCaffrey, Jesse E; Braun, Anthony R; Karim, Christine B; Thomas, David D; Sachs, Jonathan N

Interpretation of fluctuation spectra in lipid bilayer simulations

脂质双层模拟中波动谱的解释

Brandt, Erik G; Braun, Anthony R; Sachs, Jonathan N; Nagle, John F; Edholm, Olle