日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Biophysical and Structural Features of αβT-Cell Receptor Mechanosensing: A Paradigmatic Shift in Understanding T-Cell Activation

αβT细胞受体机械感知的生物物理和结构特征:理解T细胞活化的范式转变

Mallis, Robert J; Brazin, Kristine N; Duke-Cohan, Jonathan S; Akitsu, Aoi; Stephens, Hanna M; Chang-Gonzalez, Ana C; Masi, Daniel J; Kirkpatrick, Evan H; Holliday, Elizabeth L; Feng, Yinnian; Zienkiewicz, Katarzyna J; Lee, Jonathan J; Cinella, Vincenzo; Uberoy, Kaveri I; Tan, Kemin; Wagner, Gerhard; Arthanari, Haribabu; Hwang, Wonmuk; Lang, Matthew J; Reinherz, Ellis L

Atomistic TCR-ligand interactions instruct memory T-cell differentiation

原子级TCR-配体相互作用指导记忆性T细胞分化

Akitsu, Aoi; Tan, Kemin; Mallis, Robert J; Booker, Matthew A; Duke-Cohan, Jonathan S; Brazin, Kristine N; Kirkpatrick, Evan H; Parkins, Andrew N; Aryal, Sarita; Cinella, Vincenzo; Lee, Jonathan J; Uberoy, Kaveri I; Koenig, Jenna K; Biddle, Matthew; Messier, Cameron M; Lizotte, Patrick H; Tolstorukov, Michael Y; Hwang, Wonmuk; Lang, Matthew J; Reinherz, Ellis L

Parsing digital or analog TCR performance through piconewton forces

通过皮牛顿力解析数字或模拟 TCR 性能

Aoi Akitsu, Eiji Kobayashi, Yinnian Feng, Hannah M Stephens, Kristine N Brazin, Daniel J Masi, Evan H Kirkpatrick, Robert J Mallis, Jonathan S Duke-Cohan, Matthew A Booker, Vincenzo Cinella, William W Feng, Elizabeth L Holliday, Jonathan J Lee, Katarzyna J Zienkiewicz, Michael Y Tolstorukov, Wonmuk

Efficient and economic protein labeling for NMR in mammalian expression systems: Application to a preT-cell and T-cell receptor protein.

高效经济的蛋白质标记在哺乳动物表达系统中用于 NMR:应用于前 T 细胞和 T 细胞受体蛋白

Mallis Robert J, Lee Jonathan J, Berg Arjen Van den, Brazin Kristine N, Viennet Thibault, Zmuda Jonathan, Cross Melissa, Radeva Denitsa, Rodriguez-Mias Ricard, Villén Judit, Gelev Vladimir, Reinherz Ellis L, Arthanari Haribabu

Molecular design of the γδT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing

γδT细胞受体胞外结构域的分子设计使其能够在缺乏机械传感的情况下编码生物学上合适的配体识别。

Mallis, Robert J; Duke-Cohan, Jonathan S; Das, Dibyendu Kumar; Akitsu, Aoi; Luoma, Adrienne M; Banik, Debasis; Stephens, Hannah M; Tetteh, Paul W; Castro, Caitlin D; Krahnke, Sophie; Hussey, Rebecca E; Lawney, Brian; Brazin, Kristine N; Reche, Pedro A; Hwang, Wonmuk; Adams, Erin J; Lang, Matthew J; Reinherz, Ellis L

NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology

核磁共振:T细胞发育、pMHC配体识别和TCR机械生物学综合研究的重要结构工具

Mallis, Robert J; Brazin, Kristine N; Duke-Cohan, Jonathan S; Hwang, Wonmuk; Wang, Jia-Huai; Wagner, Gerhard; Arthanari, Haribabu; Lang, Matthew J; Reinherz, Ellis L

The T Cell Antigen Receptor α Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations

细胞抗原受体 α 跨膜结构域通过调节双层浸入和 CD3 亚基关联来协调触发

Kristine N Brazin, Robert J Mallis, Andras Boeszoermenyi, Yinnian Feng, Akihiro Yoshizawa, Pedro A Reche, Pavanjeet Kaur, Kevin Bi, Rebecca E Hussey, Jonathan S Duke-Cohan, Likai Song, Gerhard Wagner, Haribabu Arthanari, Matthew J Lang, Ellis L Reinherz

Mechanosensing drives acuity of αβ T-cell recognition

机械感知驱动αβ T细胞识别的敏锐性

Feng, Yinnian; Brazin, Kristine N; Kobayashi, Eiji; Mallis, Robert J; Reinherz, Ellis L; Lang, Matthew J

Structural Features of the αβTCR Mechanotransduction Apparatus That Promote pMHC Discrimination

促进pMHC识别的αβTCR机械转导装置的结构特征

Brazin, Kristine N; Mallis, Robert J; Das, Dibyendu Kumar; Feng, Yinnian; Hwang, Wonmuk; Wang, Jia-Huai; Wagner, Gerhard; Lang, Matthew J; Reinherz, Ellis L

Constitutively oxidized CXXC motifs within the CD3 heterodimeric ectodomains of the T cell receptor complex enforce the conformation of juxtaposed segments

T细胞受体复合物CD3异二聚体胞外结构域内组成型氧化的CXXC基序,能够维持相邻片段的构象。

Brazin, Kristine N; Mallis, Robert J; Li, Chen; Keskin, Derin B; Arthanari, Haribabu; Gao, Yuanwei; Wu, Shiaw-Lin; Karger, Barry L; Wagner, Gerhard; Reinherz, Ellis L