日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Machine says go, doctor says no: an ecological momentary assessment analysis examining clinicians' perceptions of, and their antibiotic prescribing behaviour when using rapid molecular diagnostic tests in intensive care

机器说可以,医生说不行:一项生态瞬时评估分析,旨在考察临床医生在重症监护中使用快速分子诊断检测时的认知及其抗生素处方行为。

Stewart, Sarah-Jane F; Enne, Virve I; Pandolfo, Alyssa M; Jani, Yogini H; Brealey, David; Brett, Stephen J; Livermore, David M; Gant, Vanya; Horne, Rob

Biomarker-Guided Antibiotic Duration for Hospitalized Patients With Suspected Sepsis: The ADAPT-Sepsis Randomized Clinical Trial

生物标志物指导疑似脓毒症住院患者的抗生素疗程:ADAPT-脓毒症随机临床试验

Dark, Paul; Hossain, Anower; McAuley, Daniel F; Brealey, David; Carlson, Gordon; Clayton, Jonathan C; Felton, Timothy W; Ghuman, Belinder K; Gordon, Anthony C; Hellyer, Thomas P; Lone, Nazir I; Manazar, Uzma; Richards, Gillian; McCullagh, Iain J; McMullan, Ronan; McNamee, James J; McNeil, Hannah C; Mouncey, Paul R; Naisbitt, Micheal J; Parker, Robert J; Poole, Ruth L; Rostron, Anthony J; Singer, Mervyn; Stevenson, Matt D; Walsh, Tim S; Welters, Ingeborg D; Whitehouse, Tony; Whiteley, Simon; Wilson, Peter; Young, Keith K; Perkins, Gavin D; Lall, Ranjit

Dexmedetomidine- or Clonidine-Based Sedation Compared With Propofol in Critically Ill Patients: The A2B Randomized Clinical Trial

右美托咪定或可乐定镇静与丙泊酚镇静在危重患者中的比较:A2B随机临床试验

Walsh, Timothy S; Parker, Richard A; Aitken, Leanne M; McKenzie, Cathrine A; Emerson, Lydia; Boyd, Julia; Macdonald, Alix; Beveridge, Gayle; Giddings, Annabel; Hope, David; Irvine, Sîan; Tuck, Sharon; Lone, Nazir I; Kydonaki, Kalliopi; Norrie, John; Brealey, David; Antcliffe, David; Reay, Michael; Williams, Alan; Bewley, Jeremy; Creagh-Brown, Benedict; McAuley, Daniel F; Dark, Paul; Wise, Matt P; Gordon, Anthony C; Perkins, Gavin D; Reade, Michael C; Blackwood, Bronagh; MacLullich, Alasdair; Glen, Robert; Page, Valerie J; Weir, Christopher J

INHALE WP3, a multicentre, open-label, pragmatic randomised controlled trial assessing the impact of rapid, ICU-based, syndromic PCR, versus standard-of-care on antibiotic stewardship and clinical outcomes in hospital-acquired and ventilator-associated pneumonia

INHALE WP3 是一项多中心、开放标签、实用性随机对照试验,旨在评估基于 ICU 的快速综合征 PCR 检测与标准治疗相比,对医院获得性肺炎和呼吸机相关性肺炎的抗菌药物管理和临床结局的影响。

Enne, Virve I; Stirling, Susan; Barber, Julie A; High, Juliet; Russell, Charlotte; Brealey, David; Dhesi, Zaneeta; Colles, Antony; Singh, Suveer; Parker, Robert; Peters, Mark; Cherian, Benny P; Riley, Peter; Dryden, Matthew; Simpson, Ruan; Patel, Nehal; Cassidy, Jane; Martin, Daniel; Welters, Ingeborg D; Page, Valerie; Kandil, Hala; Tudtud, Eleanor; Turner, David; Horne, Robert; O'Grady, Justin; Swart, Ann Marie; Livermore, David M; Gant, Vanya

An international observational study validating gene-expression sepsis immune subgroups

一项国际观察性研究验证了基因表达脓毒症免疫亚组

Antcliffe, David B; Peronnet, Estelle; Pène, Frédéric; Strålin, Kristoffer; Brealey, David; Blein, Sophie; Cleaver, Richard; Cronhjort, Maria; Diehl, Jean-Luc; Voiriot, Guillaume; Fleurie, Aurore; Lannsjö, Claudia; Lukaszewicz, Anne-Claire; Mårtensson, Johan; Pham, Tài; De Prost, Nicolas; Ricard, Jean-Damien; Singer, Mervyn; Terraz, Gabriel; Timsit, Jean-François; Unge, Christian; Vieillard-Baron, Antoine; Wahlin, Rebecka Rubenson; Llitjos, Jean-François; Gordon, Anthony C

Sepsis-induced hypocholesterolemia is linked to low cardiomyocyte membrane cholesterol and impaired catecholamine responsiveness

脓毒症引起的低胆固醇血症与心肌细胞膜胆固醇降低和儿茶酚胺反应受损有关。

Kleyman, Anna; Pisciotta, Walter; Gaupp, Charlotte; Khaliq, Waqas; Hofmaenner, Daniel; Brealey, David; Pinto, Bernardo Bollen; Andreis, Davide Tommaso; Waugh, Mark Gerard; Melis, Miranda J; Miller, Muska; Mehmetaj, Klea; Bauer, Michael; Press, Adrian; Singer, Mervyn

Plasma from patients with sepsis induces release of neutrophil extracellular traps from healthy volunteer neutrophils ex vivo

脓毒症患者的血浆可诱导健康志愿者中性粒细胞在体外释放中性粒细胞胞外陷阱(NETs)。

Villa, Antoine; Xue, Haiyan; Scully, Marie; David, Sascha; Bercades, Georgia; Brealey, David; Singer, Mervyn; Snow, Timothy Arthur Chandos; Arulkumaran, Nishkantha

Preoperative activation of the renin-angiotensin system and myocardial injury in noncardiac surgery: exploratory mechanistic analysis of the SPACE randomised controlled trial.

非心脏手术中肾素-血管紧张素系统术前激活与心肌损伤:SPACE随机对照试验的探索性机制分析

Gutierrez Del Arroyo Ana, Abbott Tom E F, Patel Akshaykumar, Begum Salma, Dias Priyanthi, Brealey David, Pearse Rupert M, Kapil Vikas, Ackland Gareth L

Digital integration of research conduct into clinical care: results of the PROSPECTOR randomised feasibility study

将研究成果数字化融入临床护理:PROSPECTOR随机可行性研究的结果

Wilson, Matthew G; Asselbergs, Folkert W; Saleem, Nausheen; Jeilani, Lelia; Brealey, David; Sydes, Matthew R; Harris, Steve

The amphiregulin- epidermal growth factor receptor axis as a therapeutic target in sepsis

双调蛋白-表皮生长因子受体轴作为脓毒症的治疗靶点

Walsh, Rebecca; Snow, Timothy Arthur Chandos; Martinez, Alexandra Z; Brealey, David; Singer, Mervyn; Das, Abhishek; Arulkumaran, Nishkantha