文献库，生知库 | 链接生命科学的每一步

日期影响因子

CRISPR Screens Identify PIK3C2A as a Novel Mediator of EGFR Inhibitor Resistance in Head and Neck Squamous Cell Carcinoma

CRISPR筛选鉴定出PIK3C2A是头颈部鳞状细胞癌中EGFR抑制剂耐药性的新型介质

期刊:Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

影响因子:2.2

doi:10.1002/hed.70048

Wang, Jiayu; Ludwig, Megan L; Kulkarni, Aditi; Birkeland, Andrew C; Michmerhuizen, Nicole L; Gensterblum-Miller, Elizabeth; Zhai, Jingyi; Jiang, Hui; Swiecicki, Paul; Buchakjian, Marisa; Heft Neal, Molly; Chinn, Steven B; Spector, Matthew E; Brenner, J Chad

细胞生物学

发表日期：2026

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UV1 plus pembrolizumab in recurrent and metastatic head and neck squamous cell carcinoma: safe, immunogenic, but lacking efficacy

UV1联合帕博利珠单抗治疗复发性和转移性头颈部鳞状细胞癌：安全、具有免疫原性，但缺乏疗效

期刊:Translational Cancer Research

影响因子:1.7

doi:10.21037/tcr-2025-1-2689

Flores, Guillermo; Buchakjian, Marisa R; Heft Neal, Molly; Brenner, J Chad

细胞生物学

免疫/内分泌

发表日期：2026

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FDG-PET-Based Selective Deescalation of Chemoradiation in Human Papillomavirus-Related Oropharyngeal Squamous Cell Carcinoma: A Multicenter Phase II Trial

基于FDG-PET的选择性降低人乳头瘤病毒相关口咽鳞状细胞癌放化疗强度：一项多中心II期试验

期刊:Clinical Cancer Research

doi:10.1158/1078-0432.CCR-25-2820

Mierzwa, Michelle; Rosen, Benjamin; Suresh, Krithika; Dinesh, Arjun; Regan, Sam; Brummel, Collin; Wong, Kakit; Casper, Keith; Prince, Mark; Malloy, Kelly; Shuman, Andrew; Chinn, Steven; Cao, Yue; Aryal, Madhava; Heft-Neal, Molly; Stucken, Chaz; Buchakjian, Marisa; Forner, David; Yalamanchi, Pratyusha; Swiecicki, Paul; Lawrence, Theodore S; Akhdar, Rawan; Tewari, Muneesh; Bhambhani, Chandan; Walline, Heather; Brenner, J Chad; Shah, Jennifer; Worden, Francis

细胞生物学

发表日期：2026

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A PP2A molecular glue overcomes RAS/MAPK inhibitor resistance in KRAS-mutant non-small cell lung cancer

PP2A分子胶克服了KRAS突变型非小细胞肺癌的RAS/MAPK抑制剂耐药性

期刊:Journal of Clinical Investigation

影响因子:13.6

doi:10.1172/JCI193790

Raines, Brynne; Tseng-Rogenski, Stephanie; Dowdican, Amanda C; Peris, Irene; Hinderman, Matthew; Zawacki, Kaitlin P; Barrie, Kelsey; Hodges Onishi, Gabrielle; Dymond, Alexander M; Luther, Tahra K; Musser, Sydney; Karaj Majchrowski, Behirda; Brenner, J Chad; Ahmed, Aqila; Taylor, Derek J; O'Connor, Caitlin M; Narla, Goutham

细胞生物学

发表日期：2025

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Genomic Signatures of Poor Prognosis in Merkel Cell Carcinoma: A Single-Institution Prospective Study

默克尔细胞癌预后不良的基因组特征：一项单中心前瞻性研究

期刊:Molecular Cancer Research

影响因子:4.7

doi:10.1158/1541-7786.MCR-24-1138

Smith, Joshua D; Bhangale, Apurva D; Gu, Wenjin; Brummel, Collin; Gensterblum-Miller, Elizabeth; McLean, Scott; Harms, Paul W; Harms, Kelly L; Bichakjian, Christopher K; Spector, Matthew E; Mills, Ryan E; Brenner, J Chad

细胞生物学

发表日期：2025

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Addressing knowledge gaps in HPV-related oropharyngeal cancer prevention: A call for action

弥合HPV相关口咽癌预防方面的知识差距：行动呼吁

期刊:Oral Oncology

影响因子:3.9

doi:10.1016/j.oraloncology.2025.107234

Dermody, Sarah M; Walline, Heather; Bhambhani, Chandan; Tewari, Muneesh; Swiecicki, Paul L; Mierzwa, Michelle; Heft Neal, Molly E; Spector, Matthew E; Brenner, J Chad

发表日期：2025

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Asymmetric integration of various cancer datasets for identifying risk-associated variants and genes

不对称整合各种癌症数据集以识别风险相关变异和基因

期刊:Bioinformatics Advances

影响因子:2.8

doi:10.1093/bioadv/vbaf253

Wang, Ruixuan; Tran, Lam; Brennan, Benjamin; Fritsche, Lars G; He, Kevin; Brenner, J Chad; Jiang, Hui

发表日期：2025

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Tumor Hypoxia and CD8(+) T-Cell Infiltration in Patients With Advanced Laryngeal Cancer

晚期喉癌患者的肿瘤乏氧和CD8(+) T细胞浸润

期刊:Otolaryngology-Head and Neck Surgery

影响因子:2.5

doi:10.1002/ohn.1291

Smith, Joshua D; Gensterblum-Miller, Elizabeth; Forner, David W A; Yalamanchi, Pratyusha; Buchakjian, Marisa R; Chinn, Steven B; Shuman, Andrew G; Casper, Keith A; Malloy, Kelly M; Stucken, Chaz L; Mclean, Scott A; Mierzwa, Michelle L; Shah, Jennifer; Swiecicki, Paul L; Worden, Francis P; Prince, Mark E P; Spector, Matthew E; Brenner, J Chad; Heft Neal, Molly E

细胞生物学

免疫/内分泌

发表日期：2025

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Combined Tumor Infiltrating Lymphocytes and PD-L1 Status in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma

复发/转移性头颈部鳞状细胞癌中肿瘤浸润淋巴细胞和PD-L1状态的联合分析

期刊:Head and Neck-Journal for the Sciences and Specialties of the Head and Neck

影响因子:2.2

doi:10.1002/hed.28128

Haring, Catherine T; Smith, Joshua D; Dermody, Sarah M; McHugh, Jonathan B; Perry, William R; Brummel, Collin; Spector, Matthew E; Brenner, J Chad; Swiecicki, Paul L

细胞生物学

发表日期：2025

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First-line therapy for recurrent metastatic head and neck squamous cell carcinoma: every rose has its thorn

复发性转移性头颈部鳞状细胞癌的一线治疗：每朵玫瑰都有刺

期刊:Translational Cancer Research

影响因子:1.7

doi:10.21037/tcr-2025-782

Hasan, Dena; Brenner, J Chad; Swiecicki, Paul L; Heft Neal, Molly E

细胞生物学

发表日期：2025

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