日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Editorial: Viral impact on CNS: mechanisms of immune dysfunction and cognitive decline

社论:病毒对中枢神经系统的影响:免疫功能障碍和认知功能下降的机制

Angelovich, Thomas A; Mediouni, Sonia; Klein, Robyn S; Estes, Jacob D; Brew, Bruce J; Churchill, Melissa J

Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV.

与前病毒DNA相关的神经炎症在HIV病毒受到抑制的感染者的大脑中持续存在

Byrnes Sarah J, Jamal Eddine Janna, Zhou Jingling, Chalmers Emily, Wanicek Emma, Osman Narin, Jenkins Trisha A, Roche Michael, Brew Bruce J, Estes Jacob D, Angelovich Thomas A, Churchill Melissa J

Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice.

在成年小鼠中,通过诱导敲除犬尿氨酸途径酶 KMO 或 QPRT,肾脏和肝脏功能得以保留。

Summers Benjamin S, Milham Luke, Bustamante Sonia, Gondal Krishan, Rentsch Peggy, Sundaram Gayathri, Lovelace Michael D, Vissel Bryce, Brew Bruce J

Persistent cell-associated HIV-1 RNA in virally suppressed individuals on INSTI-based ART

在接受基于整合酶抑制剂的抗逆转录病毒疗法的病毒抑制个体中,仍存在持续的细胞相关 HIV-1 RNA

Suzuki, Kazuo; Gold, Lucy; Levert, Angelique; Butterly, Shannen; Yoo, Emma; Ishida, Takaomi; Zaunders, John; Cysique, Lucette A; Brew, Bruce J

Neuropathogenesis of acute HIV: mechanisms, biomarkers, and therapeutic approaches

急性 HIV 感染的神经发病机制:机制、生物标志物和治疗方法

Jia, Fangzhi Frank; Brew, Bruce J

Brain RNA profiling highlights multiple disease pathways in persons with HIV-associated neurocognitive disorder

脑RNA谱分析揭示了HIV相关神经认知障碍患者的多种疾病通路

Branton, William G; Zhang, Na; Cohen, Eric A; Brew, Bruce J; Gill, M John; Gelman, Benjamin B; Kong, Linglong; Power, Christopher

A Review of the Evidence for Tryptophan and the Kynurenine Pathway as a Regulator of Stem Cell Niches in Health and Disease

对色氨酸和犬尿氨酸通路作为健康和疾病中干细胞微环境调节因子的证据综述

Summers, Benjamin Sebastian; Thomas Broome, Sarah; Pang, Tsz Wai Rosita; Mundell, Hamish D; Koh Belic, Naomi; Tom, Nicole C; Ng, Mei Li; Yap, Maylin; Sen, Monokesh K; Sedaghat, Sara; Weible, Michael W; Castorina, Alessandro; Lim, Chai K; Lovelace, Michael D; Brew, Bruce J

The roles of the kynurenine pathway in COVID-19 neuropathogenesis

犬尿氨酸通路在 COVID-19 神经发病机制中的作用

Dehhaghi, Mona; Heydari, Mostafa; Panahi, Hamed Kazemi Shariat; Lewin, Sharon R; Heng, Benjamin; Brew, Bruce J; Guillemin, Gilles J

Meaningful cognitive decline is uncommon in virally suppressed HIV, but sustained impairment, subtle decline and abnormal cognitive aging are not

病毒载量受到抑制的艾滋病毒感染者出现显著认知能力下降的情况并不常见,但持续性认知功能障碍、轻微认知能力下降和异常认知老化却并不少见。

Aung, Htein Linn; Siefried, Krista J; Gates, Thomas M; Brew, Bruce J; Mao, Limin; Carr, Andrew; Cysique, Lucette A

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

对病毒血症和病毒抑制的HIV感染者脑内完整和缺陷型HIV前病毒进行区域分析

Angelovich, Thomas A; Cochrane, Catherine R; Zhou, Jingling; Tumpach, Carolin; Byrnes, Sarah J; Jamal Eddine, Janna; Waring, Emily; Busman-Sahay, Kathleen; Deleage, Claire; Jenkins, Trisha A; Hearps, Anna C; Turville, Stuart; Gorry, Paul R; Lewin, Sharon R; Brew, Bruce J; Estes, Jacob D; Roche, Michael; Churchill, Melissa J