日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

IgG Fc engineering to modulate antibody effector functions

通过IgG Fc工程改造来调节抗体效应功能

Wang, Xinhua; Mathieu, Mary; Brezski, Randall J

A single proteolytic cleavage within the lower hinge of trastuzumab reduces immune effector function and in vivo efficacy.

曲妥珠单抗下铰链区内的单个蛋白水解切割会降低免疫效应功能和体内疗效

Fan Xuejun, Brezski Randall J, Fa Ming, Deng Hui, Oberholtzer Allison, Gonzalez Anneliese, Dubinsky William P, Strohl William R, Jordan Robert E, Zhang Ningyan, An Zhiqiang

The origins, specificity, and potential biological relevance of human anti-IgG hinge autoantibodies

人类抗IgG铰链区自身抗体的起源、特异性和潜在生物学意义

Brezski, Randall J; Knight, David M; Jordan, Robert E

Cleavage of IgGs by proteases associated with invasive diseases: an evasion tactic against host immunity?

侵袭性疾病相关蛋白酶对 IgG 的切割:一种逃避宿主免疫的策略?

Brezski, Randall J; Jordan, Robert E

Tumor-associated and microbial proteases compromise host IgG effector functions by a single cleavage proximal to the hinge

肿瘤相关蛋白酶和微生物蛋白酶通过在铰链区附近的一次切割,破坏宿主IgG效应功能。

Brezski, Randall J; Vafa, Omid; Petrone, Diane; Tam, Susan H; Powers, Gordon; Ryan, Mary H; Luongo, Jennifer L; Oberholtzer, Allison; Knight, David M; Jordan, Robert E