日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Designed endocytosis-inducing proteins degrade targets and amplify signals

设计的内吞诱导蛋白可降解靶标并放大信号

Buwei Huang #, Mohamad Abedi #, Green Ahn #, Brian Coventry #, Isaac Sappington, Cong Tang, Rong Wang, Thomas Schlichthaerle, Jason Z Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam Chazin-Gray, Sidney Chan, Stacey Gerben, Analisa Murray, Shunzhi Wang, Jason O'Neill, Li Yi, Ronald Yeh, Ayesh

Modulation of FGF pathway signaling and vascular differentiation using designed oligomeric assemblies

利用设计的寡聚体组装体调控FGF通路信号传导和血管分化

Natasha I Edman ,Ashish Phal ,Rachel L Redler ,Thomas Schlichthaerle ,Sanjay R Srivatsan ,Devon Duron Ehnes ,Ali Etemadi ,Seong J An ,Andrew Favor ,Zhe Li ,Florian Praetorius ,Max Gordon ,Thomas Vincent ,Silvia Marchiano ,Leslie Blakely ,Chuwei Lin ,Wei Yang ,Brian Coventry ,Derrick R Hicks ,Longxing Cao ,Neville Bethel ,Piper Heine ,Analisa Murray ,Stacey Gerben ,Lauren Carter ,Marcos Miranda ,Babak Negahdari ,Sangwon Lee ,Cole Trapnell ,Ying Zheng ,Charles E Murry ,Devin K Schweppe ,Benjamin S Freedman ,Lance Stewart ,Damian C Ekiert ,Joseph Schlessinger ,Jay Shendure ,Gira Bhabha ,Hannele Ruohola-Baker ,David Baker

Accurate de novo design of heterochiral protein-protein interactions

异手性蛋白质-蛋白质相互作用的精确从头设计

Ke Sun #, Sicong Li #, Bowen Zheng #, Yanlei Zhu #, Tongyue Wang #, Mingfu Liang, Yue Yao, Kairan Zhang, Jizhong Zhang, Hongyong Li, Dongyang Han, Jishen Zheng, Brian Coventry, Longxing Cao, David Baker, Lei Liu, Peilong Lu2

De novo design of miniprotein antagonists of cytokine storm inducers

细胞因子风暴诱导剂的微蛋白拮抗剂的从头设计

Buwei Huang #, Brian Coventry #, Marta T Borowska #, Dimitrios C Arhontoulis #, Marc Exposit #, Mohamad Abedi, Kevin M Jude, Samer F Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Maggie Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance Stewart, Debor

Designed miniproteins potently inhibit and protect against MERS-CoV

设计的微型蛋白可有效抑制和预防 MERS-CoV

Robert J Ragotte, M Alejandra Tortorici, Nicholas J Catanzaro, Amin Addetia, Brian Coventry, Heather M Froggatt, Jimin Lee, Cameron Stewart, Jack T Brown, Inna Goreshnik, Jeremiah N Sims, Lukas F Milles, Basile I M Wicky, Matthias Glögl, Stacey Gerben, Alex Kang, Asim K Bera, William Sharkey, Alexan

Improving de novo protein binder design with deep learning

利用深度学习改进从头蛋白质结合剂设计

Nathaniel R Bennett #, Brian Coventry #, Inna Goreshnik, Buwei Huang, Aza Allen, Dionne Vafeados, Ying Po Peng, Justas Dauparas, Minkyung Baek, Lance Stewart, Frank DiMaio, Steven De Munck, Savvas N Savvides, David Baker

Designed Endocytosis-Triggering Proteins mediate Targeted Degradation

设计的内吞触发蛋白介导靶向降解

Buwei Huang, Mohamad Abedi, Green Ahn, Brian Coventry, Isaac Sappington, Rong Wang, Thomas Schlichthaerle, Jason Z Zhang, Yujia Wang, Inna Goreshnik, Ching Wen Chiu, Adam Chazin-Gray, Sidney Chan, Stacey Gerben, Analisa Murray, Shunzhi Wang, Jason O'Neill, Ronald Yeh, Ayesha Misquith, Anitra Wolf, L

Design of protein-binding proteins from the target structure alone

仅从目标结构设计蛋白质结合蛋白

Longxing Cao #, Brian Coventry #, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora Picton

Computational design of a neutralizing antibody with picomolar binding affinity for all concerning SARS-CoV-2 variants

对所有相关 SARS-CoV-2 变体具有皮摩尔结合亲和力的中和抗体的计算设计

Bo-Seong Jeong, Jeong Seok Cha, Insu Hwang, Uijin Kim, Jared Adolf-Bryfogle, Brian Coventry, Hyun-Soo Cho, Kyun-Do Kim, Byung-Ha Oh

Perturbing the energy landscape for improved packing during computational protein design

在计算蛋白质设计过程中扰动能量景观以改善堆积

Jack B Maguire, Hugh K Haddox, Devin Strickland, Samer F Halabiya, Brian Coventry, Jermel R Griffin, Surya V S R K Pulavarti, Matthew Cummins, David F Thieker, Eric Klavins, Thomas Szyperski, Frank DiMaio, David Baker, Brian Kuhlman