日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

GLP-1-directed NMDA receptor antagonism for obesity treatment

GLP-1 靶向 NMDA 受体拮抗剂用于肥胖症治疗

Jonas Petersen, Mette Q Ludwig, Vaida Juozaityte, Pablo Ranea-Robles, Charlotte Svendsen, Eunsang Hwang, Amalie W Kristensen, Nicole Fadahunsi, Jens Lund, Alberte W Breum, Cecilie V Mathiesen, Luisa Sachs, Roger Moreno-Justicia, Rebecca Rohlfs, James C Ford, Jonathan D Douros, Brian Finan, Bryan Por

Characterization of genetic variants of GIPR reveals a contribution of β-arrestin to metabolic phenotypes

GIPR 基因变异的表征揭示了 β-arrestin 对代谢表型的贡献

Hüsün S Kizilkaya #, Kimmie V Sørensen #, Jakob S Madsen #, Peter Lindquist, Jonathan D Douros, Jette Bork-Jensen, Alessandro Berghella, Peter A Gerlach, Lærke S Gasbjerg, Jacek Mokrosiński, Stephanie A Mowery, Patrick J Knerr, Brian Finan, Jonathan E Campbell, David A D'Alessio, Diego Perez-Tilve, 

Loss of GIPR in LEPR cells impairs glucose control by GIP and GIP:GLP-1 co-agonism without affecting body weight and food intake in mice

LEPR 细胞中 GIPR 的缺失会损害 GIP 和 GIP:GLP-1 共同激动对葡萄糖的控制,但不会影响小鼠的体重和食物摄入量

Seun Akindehin, Arkadiusz Liskiewicz, Daniela Liskiewicz, Miriam Bernecker, Cristina Garcia-Caceres, Daniel J Drucker, Brian Finan, Gerald Grandl, Robert Gutgesell, Susanna M Hofmann, Ahmed Khalil, Xue Liu, Perla Cota, Mostafa Bakhti, Oliver Czarnecki, Aimée Bastidas-Ponce, Heiko Lickert, Lingru Kan

Toward once-monthly insulin therapy via synergy in two pharmacokinetic protractors: Fc-conjugation and fatty acid acylation

通过两种药代动力学指标的协同作用实现每月一次的胰岛素治疗:Fc 结合和脂肪酸酰化

Alexander N Zaykov, Vasily M Gelfanov, Tina M Tagmose, Damien Demozay, Valentina Manfè, Rebecca Rohlfs, Marita Rivir, Diego Perez-Tilve, Brian Finan, Richard D DiMarchi

The incretin co-agonist tirzepatide requires GIPR for hormone secretion from human islets

肠促胰岛素联合激动剂 tirzepatide 需要 GIPR 才能从人类胰岛分泌激素

Kimberley El #, Jonathan D Douros #, Francis S Willard, Aaron Novikoff, Ashot Sargsyan, Diego Perez-Tilve, David B Wainscott, Bin Yang, Alex Chen, Donald Wothe, Callum Coupland, Mattias H Tschöp, Brian Finan, David A D'Alessio, Kyle W Sloop, Timo D Müller, Jonathan E Campbell5

Glucose-dependent insulinotropic polypeptide regulates body weight and food intake via GABAergic neurons in mice

葡萄糖依赖性促胰岛素多肽通过GABA能神经元调节小鼠的体重和食物摄入量。

Arkadiusz Liskiewicz ,Ahmed Khalil,Daniela Liskiewicz ,Aaron Novikoff,Gerald Grandl,Gandhari Maity-Kumar,Robert M Gutgesell,Mostafa Bakhti ,Aimée Bastidas-Ponce ,Oliver Czarnecki ,Konstantinos Makris,Heiko Lickert ,Annette Feuchtinger,Monica Tost,Callum Coupland,Lisa Ständer,Seun Akindehin,Sneha Prakash,Faiyaz Abrar,Russell L Castelino,Yantao He,Patrick J Knerr,Bin Yang,Wouter F J Hogendorf,Shiqi Zhang,Susanna M Hofmann ,Brian Finan,Richard D DiMarchi,Matthias H Tschöp ,Jonathan D Douros,Timo D Müller

Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

Vps37a 通过控制胰高血糖素受体定位到内体来调节肝葡萄糖的产生

Revathi Sekar, Karsten Motzler, Yun Kwon, Aaron Novikoff, Julia Jülg, Bahar Najafi, Surui Wang, Anna-Luisa Warnke, Susanne Seitz, Daniela Hass, Sofiya Gancheva, Sabine Kahl, Bin Yang, Brian Finan, Kathrin Schwarz, Juergen G Okun, Michael Roden, Matthias Blüher, Timo D Müller, Natalie Krahmer, Christ

Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems

发现一种对啮齿动物和人类系统有效的强效 GIPR 肽拮抗剂

Bin Yang, Vasily M Gelfanov, Kimberley El, Alex Chen, Rebecca Rohlfs, Barent DuBois, Ann Maria Kruse Hansen, Diego Perez-Tilve, Patrick J Knerr, David D'Alessio, Jonathan E Campbell, Jonathan D Douros, Brian Finan

Hepatic mTORC2 Signaling Facilitates Acute Glucagon Receptor Enhancement of Insulin-Stimulated Glucose Homeostasis in Mice

肝脏 mTORC2 信号促进小鼠急性胰高血糖素受体增强胰岛素刺激的葡萄糖稳态

Teayoun Kim, Shelly Nason, Jessica Antipenko, Brian Finan, Anath Shalev, Richard DiMarchi, Kirk M Habegger

Pharmacological but not physiological GDF15 suppresses feeding and the motivation to exercise

GDF15 具有药理作用,但并非生理作用,可抑制摄食和运动动机

Anders B Klein #, Trine S Nicolaisen #, Niels Ørtenblad, Kasper D Gejl, Rasmus Jensen, Andreas M Fritzen, Emil L Larsen, Kristian Karstoft, Henrik E Poulsen, Thomas Morville, Ronni E Sahl, Jørn W Helge, Jens Lund, Sarah Falk, Mark Lyngbæk, Helga Ellingsgaard, Bente K Pedersen, Wei Lu, Brian Finan, S