日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Modelling a pathological GSX2 variant that selectively alters DNA binding reveals hypomorphic mouse brain defects

对一种选择性改变DNA结合的致病性GSX2变体进行建模,揭示了小鼠脑部功能减弱的缺陷。

Laura Tweedie ,Matthew R Riccetti ,Brittany Cain ,Shenyue Qin ,Joseph Salomone ,Jordan A Webb ,Amy Riesenberg ,Lisa A Ehrman ,Ronald R Waclaw ,Rhett A Kovall ,Brian Gebelein ,Kenneth Campbell

A Drosophila Su(H) model of Adams-Oliver Syndrome reveals cofactor titration as a mechanism underlying developmental defects

亚当斯-奥利弗综合征的果蝇 Su(H) 模型揭示了辅因子滴定是导致发育缺陷的机制

Ellen K Gagliani, Lisa M Gutzwiller, Yi Kuang, Yoshinobu Odaka, Phillipp Hoffmeister, Stefanie Hauff, Aleksandra Turkiewicz, Emily Harding-Theobald, Patrick J Dolph, Tilman Borggrefe, Franz Oswald, Brian Gebelein, Rhett A Kovall

Mechanisms of stearoyl CoA desaturase inhibitor sensitivity and acquired resistance in cancer

硬脂酰辅酶 A 去饱和酶抑制剂敏感性和癌症获得性耐药性的机制

Nicole Oatman, Nupur Dasgupta, Priyanka Arora, Kwangmin Choi, Mruniya V Gawali, Nishtha Gupta, Sreeja Parameswaran, Joseph Salomone, Julie A Reisz, Sean Lawler, Frank Furnari, Cameron Brennan, Jianqiang Wu, Larry Sallans, Gary Gudelsky, Pankaj Desai, Brian Gebelein, Matthew T Weirauch, Angelo D'Ales

Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice

保守的Gsx2/Ind同源结构域单体与同源二聚体DNA结合决定了果蝇和小鼠的调控结果

Joseph Salomone,Shenyue Qin,Temesgen D Fufa,Brittany Cain,Edward Farrow,Bin Guan,Robert B Hufnagel,Masato Nakafuku,Hee-Woong Lim,Kenneth Campbell,Brian Gebelein

Enhancers with cooperative Notch binding sites are more resistant to regulation by the Hairless co-repressor

具有合作性 Notch 结合位点的增强子更能抵抗无毛辅阻遏物的调控

Yi Kuang, Anna Pyo, Natanel Eafergan, Brittany Cain, Lisa M Gutzwiller, Ofri Axelrod, Ellen K Gagliani, Matthew T Weirauch, Raphael Kopan, Rhett A Kovall, David Sprinzak, Brian Gebelein

Notch dimerization and gene dosage are important for normal heart development, intestinal stem cell maintenance, and splenic marginal zone B-cell homeostasis during mite infestation

Notch二聚化和基因剂量对于正常心脏发育、肠道干细胞维持以及螨虫侵染期间脾脏边缘区B细胞稳态至关重要。

Francis M Kobia ,Kristina Preusse ,Quanhui Dai ,Nicholas Weaver ,Matthew R Hass ,Praneet Chaturvedi ,Sarah J Stein ,Warren S Pear ,Zhenyu Yuan ,Rhett A Kovall ,Yi Kuang ,Natanel Eafergen ,David Sprinzak ,Brian Gebelein ,Eric W Brunskill ,Raphael Kopan

Enhancer architecture sensitizes cell specific responses to Notch gene dose via a bind and discard mechanism

增强子结构通过结合和丢弃机制使细胞对 Notch 基因剂量产生特异性反应

Yi Kuang #, Ohad Golan #, Kristina Preusse, Brittany Cain, Collin J Christensen, Joseph Salomone, Ian Campbell, FearGod V Okwubido-Williams, Matthew R Hass, Zhenyu Yuan, Nathanel Eafergan, Kenneth H Moberg, Rhett A Kovall, Raphael Kopan, David Sprinzak, Brian Gebelein

Gli3 utilizes Hand2 to synergistically regulate tissue-specific transcriptional networks

Gli3 利用 Hand2 协同调节组织特异性转录网络

Kelsey H Elliott, Xiaoting Chen, Joseph Salomone, Praneet Chaturvedi, Preston A Schultz, Sai K Balchand, Jeffrey D Servetas, Aimée Zuniga, Rolf Zeller, Brian Gebelein, Matthew T Weirauch, Kevin A Peterson, Samantha A Brugmann

Physical interactions between Gsx2 and Ascl1 balance progenitor expansion versus neurogenesis in the mouse lateral ganglionic eminence

Gsx2 和 Ascl1 之间的物理相互作用平衡了小鼠侧神经节隆起中的祖细胞扩增与神经发生。

Kaushik Roychoudhury ,Joseph Salomone ,Shenyue Qin ,Brittany Cain ,Mike Adam ,S Steven Potter ,Masato Nakafuku ,Brian Gebelein ,Kenneth Campbell

A Comprehensive Structure-Function Study of Neurogenin3 Disease-Causing Alleles during Human Pancreas and Intestinal Organoid Development

神经原素 3 致病等位基因在人类胰腺和肠道类器官发育过程中的综合结构功能研究

Xinghao Zhang, Patrick S McGrath, Joseph Salomone, Mohamed Rahal, Heather A McCauley, Jamie Schweitzer, Rhett Kovall, Brian Gebelein, James M Wells