日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Microglia depletion reduces human neuronal APOE4-related pathologies in a chimeric Alzheimer's disease model

在嵌合型阿尔茨海默病模型中,小胶质细胞耗竭可减轻人类神经元中与 APOE4 相关的病理变化。

Antara Rao ,Nuo Chen ,Min Joo Kim ,Jessica Blumenfeld ,Oscar Yip ,Zherui Liang ,David Shostak ,Yanxia Hao ,Maxine R Nelson ,Nicole Koutsodendris ,Brian Grone ,Leo Ding ,Seo Yeon Yoon ,Patrick Arriola ,Misha Zilberter ,Yadong Huang

The APOE-R136S mutation protects against APOE4-driven Tau pathology, neurodegeneration and neuroinflammation

APOE-R136S 突变可预防 APOE4 驱动的 Tau 病理、神经退行性和神经炎症

Maxine R Nelson, Peng Liu, Ayushi Agrawal, Oscar Yip, Jessica Blumenfeld, Michela Traglia, Min Joo Kim, Nicole Koutsodendris, Antara Rao, Brian Grone, Yanxia Hao, Seo Yeon Yoon, Qin Xu, Samuel De Leon, Tenzing Choenyi, Reuben Thomas, Francisco Lopera, Yakeel T Quiroz, Joseph F Arboleda-Velasquez, Er

Neuronal APOE4 removal protects against tau-mediated gliosis, neurodegeneration and myelin deficits

神经元 APOE4 去除可防止 tau 介导的神经胶质增生、神经退行性病变和髓鞘缺陷

Nicole Koutsodendris, Jessica Blumenfeld, Ayushi Agrawal, Michela Traglia, Brian Grone, Misha Zilberter, Oscar Yip, Antara Rao, Maxine R Nelson, Yanxia Hao, Reuben Thomas, Seo Yeon Yoon, Patrick Arriola, Yadong Huang2

APOE4-promoted gliosis and degeneration in tauopathy are ameliorated by pharmacological inhibition of HMGB1 release

APOE4 促进的 tau 蛋白病变中的胶质增生和退行性变可通过药理学抑制 HMGB1 释放而得到改善。

Nicole Koutsodendris ,Jessica Blumenfeld ,Ayushi Agrawal ,Michela Traglia ,Oscar Yip ,Antara Rao ,Min Joo Kim ,Maxine R Nelson ,Yung-Hua Wang ,Brian Grone ,Yanxia Hao ,Reuben Thomas ,Misha Zilberter ,Seo Yeon Yoon ,Patrick Arriola ,Yadong Huang

Microglia Depletion Reduces Human Neuronal APOE4-Driven Pathologies in a Chimeric Alzheimer's Disease Model

小胶质细胞耗竭可减少嵌合阿尔茨海默病模型中人类神经元 APOE4 驱动的病理

Antara Rao, Nuo Chen, Min Joo Kim, Jessica Blumenfeld, Oscar Yip, Yanxia Hao, Zherui Liang, Maxine R Nelson, Nicole Koutsodendris, Brian Grone, Leo Ding, Seo Yeon Yoon, Patrick Arriola, Yadong Huang