日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

An oral, liver-restricted LXR inverse agonist for dyslipidemia: preclinical development and phase 1 trial

一种用于治疗血脂异常的口服、肝脏限制性 LXR 反向激动剂:临床前开发和 I 期试验

Li, Xiaoxu; Benegiamo, Giorgia; Vijayakumar, Archana; Sroda, Natalie; Kimura, Masaki; Huss, Ryan S; Weng, Steve; Murakami, Eisuke; Kirby, Brian J; von Alvensleben, Giacomo V G; Kremoser, Claus; Gane, Edward J; Takebe, Takanori; Myers, Robert P; Subramanian, G Mani; Auwerx, Johan

Blocking RAN translation without altering repeat RNAs rescues C9ORF72-related ALS and FTD phenotypes

阻断 RAN 翻译而不改变重复 RNA 可挽救 C9ORF72 相关 ALS 和 FTD 表型

Jiang, Xin; Schaeffer, Laure; Patni, Divya; Russo, Tommaso; Lee, Chao-Zong; Aguilar, Corey; Marques, Christine; Jansen-West, Karen; Hruska-Plochan, Marian; Ray-Soni, Ananya; Lim, Su Min; Held, Aaron; Yue, Mei; Castellanos Otero, Paula; Aryal, Sandeep; Beaussant, Hortense D A M; Basu, Himanish; Takakuwa, Hiro; Daughrity, Lillian M; Ramesh, Nandini; Da Costa, Paulo; A A Quadros, Ana Rita; Nolan, Matthew; Reyes, Charles Jourdan F; Wheeler, Hayden; Moran, Laura C; Griesman, Grant; Wymann, Benjamin; Trombetta, Bianca A; Lopez-De-Silanes, Emma Sofia; Canori, Michael; Krishnan, Gopinath; Vieira Souza Da Silva, Yasmim; Eriani, Gilbert; Albers, Mark W; Arnold, Steven E; Song, Yuyu; Jain, Ankur; Chiu, Isaac M; Zhang, Yong-Jie; Gao, Fen-Biao; Wainger, Brian J; Polymenidou, Magdalini; Petrucelli, Leonard; Martin, Franck; Lagier-Tourenne, Clotilde

Structural basis for the recruitment and selective phosphorylation of Akt by mTORC2.

mTORC2 募集和选择性磷酸化 Akt 的结构基础。

Taylor Martin S, Chen Maggie, Hancock Matthew, Wranik Maximilian, Miller Bryant D, O'Meara Timothy R, Palanski Brad A, Ficarro Scott B, Groendyke Brian J, Xiang Yufei, Kondo Kazuma T, Linde-Garelli Karen Y, Lee Michelle J, Mondal Dibyendu, Freund Daniel, Congreve Samantha, Matas Kaay, Hennink Maximiliaan, Xibinaku Kera, Valenstein Max L, van Eeuwen Trevor, Marto Jarrod A, Sali Andrej, Shi Yi, Gray Nathanael S, Sabatini David M, Chu Nam, Rogala Kacper B, Cole Philip A

Hepatic adaptation to chronic metabolic stress primes tumorigenesis.

肝脏对慢性代谢应激的适应会促进肿瘤发生。

Tzouanas Constantine N, Shay Jessica E S, Sherman Marc S, Rubin Adam J, Mead Benjamin E, Dao Tyler T, Tao Junyan, Lehrich Brandon M, Eng George, Patterson-Fortin Jeffrey, Butzlaff Titus, Mana Miyeko D, Kolb Kellie E, Walesky Chad, Pepe-Mooney Brian J, Smith Colton J, Prakadan Sanjay M, Ramseier Michelle L, Tong Yuzhou Evelyn, Joung Julia, Chi Fangtao, McMahon-Skates Thomas, Winston Carolyn L, Jeong Woo-Jeong, Aney Katherine J, Chen Ethan, Nissim Sahar, Zhang Feng, Deshpande Vikram, Monga Satdarshan P, Lauer Georg M, Goessling Wolfram, Yilmaz Ömer H, Shalek Alex K

Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein.

通过靶向细胞表面 RNA 结合蛋白治疗急性髓系白血病模型。

George Benson M, Eleftheriou Maria, Yankova Eliza, Perr Jonathan, Chai Peiyuan, Nestola Gianluca, Almahayni Karim, Evans Siân, Damaskou Aristi, Hemberger Helena, Lebedenko Charlotta G, Rak Justyna, Yu Qi, Bapcum Ece, Russell James, Bagri Jaana, Volk Regan F, Spiekermann Malte, Stone Richard M, Giotopoulos George, Huntly Brian J P, Baxter Joanna, Camargo Fernando, Liu Jie, Zaro Balyn W, Vassiliou George S, Möckl Leonhard, de la Rosa Jorge, Flynn Ryan A, Tzelepis Konstantinos

Low-Dose Lithium for Mild Cognitive Impairment: A Pilot Randomized Clinical Trial

低剂量锂治疗轻度认知障碍:一项初步随机临床试验

Gildengers, Ariel G; Ibrahim, Tamer S; Anderson, Stewart J; Emanuel, James E; Santini, Tales; Diaz, Jihui L; Lopresti, Brian J; Royse, Sarah K; Lopez, Oscar L; Zeng, Xuemei; de Almeida, Bruno; Alkhateeb, Salem K; Chu, Cong; Karikari, Thomas K; Lee, Laisze; Weinstein, Andrea M; Butters, Meryl A

Lysine-11 ubiquitination drives type-I/III interferon induction by cGAS-STING and Toll-like receptors 3 and 4

赖氨酸-11泛素化通过cGAS-STING和Toll样受体3和4驱动I/III型干扰素的诱导。

Betrancourt, Alexis; Cinko, M Talha; Varanda, Ana Beatriz; Arias, Maykel; Uranga-Murillo, Iratxe; Peña, Natacha; Kaps, Lucia-Maria; Chau, Long Fung; Buratti, Bianca; Brägelmann, Johannes; de Miguel, Diego; Becker, Kerstin; Casper, Ramona; Martin, Rocio; Alcami, Antonio; Ferguson, Brian J; Pardo, Julian; Rieser, Eva; Walczak, Henning

A stabilized MERS-CoV spike ferritin nanoparticle vaccine elicits robust and protective neutralizing antibody responses

一种稳定的MERS-CoV刺突蛋白铁蛋白纳米颗粒疫苗可诱导产生强效且具有保护作用的中和抗体反应。

Powell, Abigail E; Caruso, Hannah; Park, Soyoon; Chen, Jui-Lin; O'Rear, Jessica; Ferrer, Brian J; Stieh, Daniel J; Weiss, Adam M; Belnap, David M; Walker, Audrey; Bruening, Anneliese; Hartwig, Airn; Sprouse, Kaitlin R; Addetia, Amin; Alshukairi, Abeer N; Ahyong, Vida; Dougherty, Cristy S; Veesler, David; Bowen, Richard; Ledgerwood, Julie E; Kay, Michael S; Weidenbacher, Payton A-B; Palanski, Brad A

Publisher Correction: Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial

出版商更正:突变型 KRAS 疫苗联合双重免疫检查点阻断治疗切除胰腺癌:一项 I 期试验

Huff, Amanda L; Haldar, S Daniel; Girgis, Alexander A; Wang, Hejia Henry; Danilova, Ludmila; Heumann, Thatcher; Berg, Maureen; Wang, Yuxuan; Andaloori, Lalitya; Hernandez, Alexei; Longway, Gabriella; Barrett, Benjamin; Zhu, Zirui; Davis-Marcisak, Emily; Thoburn, Christopher; Leatherman, James; Mitchell, Sarah; Lee, Jae W; Shu, Daniel H; Konig, Maximillian F; Mog, Brian J; Montagne, Janelle; Coyne, Erin M; Bever, Katherine; Baretti, Marina; Yarchoan, Mark; Anders, Robert A; Kagohara, Luciane T; Laheru, Daniel; Thomas, Amy M; Durham, Jennifer; Nauroth, Julie M; Lu, Jiayun; Wang, Hao; Fertig, Elana J; Ho, Won Jin; Azad, Nilofer S; Jaffee, Elizabeth M; Zaidi, Neeha

Allelic variation of Avr genes in highly virulent strains explains severe wheat stem rust epidemics

高致病性菌株中Avr基因的等位基因变异解释了小麦秆锈病的严重流行。

Spanner, Rebecca E; Henningsen, Eva C; Langlands-Perry, Camilla; Chen, Jian; Lubega, Jibril; Matny, Oadi; Lewis, David; Cheah, Li Chen; Su, Zhouyang; Feist, Alexis; Nazareno, Eric S; Li, Feng; Outram, Megan A; Arndell, Taj; Vanhercke, Thomas; Virzì, Nino; Luo, Ming; Ayliffe, Michael; Stone, Eric; Kanyuka, Kostya; Sperschneider, Jana; Dodds, Peter N; Steffenson, Brian J; Figueroa, Melania