日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Intermittent glucocorticoid treatment improves muscle metabolism via the PGC1α/Lipin1 axis in an aging-related sarcopenia model

间歇性糖皮质激素治疗可通过 PGC1α/Lipin1 轴改善衰老相关肌肉减少症模型中的肌肉代谢

Ashok D Prabakaran, Kevin McFarland, Karen Miz, Hima Bindu Durumutla, Kevin Piczer, Fadoua El Abdellaoui Soussi, Hannah Latimer, Cole Werbrich, Hyun-Jy Chung, N Scott Blair, Douglas P Millay, Andrew J Morris, Brendan Prideaux, Brian N Finck, Mattia Quattrocelli

Hepatocyte Period 1 dictates oxidative substrate selection independent of the core circadian clock

肝细胞周期1决定氧化底物的选择,而与核心生物钟无关。

Jiameng Sun ,Yiming Zhang ,Joshua A Adams ,Cassandra B Higgins ,Shannon C Kelly ,Hao Zhang ,Kevin Y Cho ,Ulysses G Johnson ,Benjamin M Swarts ,Shun-Ichi Wada ,Gary J Patti ,Leah P Shriver ,Brian N Finck ,Erik D Herzog ,Brian J DeBosch

Conditional hepatocyte ablation of PDIA1 uncovers indispensable roles in both APOB and MTTP folding to support VLDL secretion

PDIA1 在肝细胞中的条件性消融揭示了其在 APOB 和 MTTP 折叠中对支持 VLDL 分泌的不可或缺的作用

Zhouji Chen, Shiyu Wang, Anita Pottekat, Alec Duffey, Insook Jang, Benny H Chang, Jaehyung Cho, Brian N Finck, Nicholas O Davidson, Randal J Kaufman

Exploring lipin1 as a promising therapeutic target for the treatment of Duchenne muscular dystrophy

探索 lipin1 作为治疗杜氏肌营养不良症的有希望的治疗靶点

Abdulrahman Jama #, Abdullah A Alshudukhi #, Steve Burke, Lixin Dong, John Karanja Kamau, Brooklyn Morris, Ibrahim A Alkhomsi, Brian N Finck, Andrew Alvin Voss, Hongmei Ren

ANGPTL3 deficiency impairs lipoprotein production and produces adaptive changes in hepatic lipid metabolism

ANGPTL3 缺乏会损害脂蛋白的产生,并导致肝脏脂质代谢发生适应性变化

Kendall H Burks, Yan Xie, Michael Gildea, In-Hyuk Jung, Sandip Mukherjee, Paul Lee, Upasana Pudupakkam, Ryan Wagoner, Ved Patel, Katherine Santana, Arturo Alisio, Ira J Goldberg, Brian N Finck, Edward A Fisher, Nicholas O Davidson, Nathan O Stitziel

Disruption of hepatic mitochondrial pyruvate and amino acid metabolism impairs gluconeogenesis and endurance exercise capacity in mice

肝线粒体丙酮酸和氨基酸代谢中断会损害小鼠的糖异生和耐力运动能力

Michael R Martino, Mohammad Habibi, Daniel Ferguson, Rita T Brookheart, John P Thyfault, Gretchen A Meyer, Louise Lantier, Curtis C Hughey, Brian N Finck

Lipin1 as a therapeutic target for respiratory insufficiency of duchenne muscular dystrophy

Lipin1 作为杜氏肌营养不良症呼吸功能不全的治疗靶点

Alexandra Brown, Brooklyn Morris, John Karanja Kamau, Ryan J Rakoczy, Brian N Finck, Christopher N Wyatt, Hongmei Ren

Site-1 protease inhibits mitochondrial respiration by controlling the TGF-β target gene Mss51

Site-1 蛋白酶通过控制 TGF-β 靶基因 Mss51 抑制线粒体呼吸

Muhammad G Mousa, Lahari Vuppaladhadiam, Meredith O Kelly, Terri Pietka, Shelby Ek, Karen C Shen, Gretchen A Meyer, Brian N Finck, Rita T Brookheart

Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult

肝脏丙酮酸和丙氨酸代谢对于维持抗氧化能力和抵抗氧化损伤至关重要且相互补充

Nicole K H Yiew, Joel H Vazquez, Michael R Martino, Stefanie Kennon-McGill, Jake R Price, Felicia D Allard, Eric U Yee, Alexander J Layman, Laura P James, Kyle S McCommis, Brian N Finck, Mitchell R McGill

Mitochondrial pyruvate carrier inhibition initiates metabolic crosstalk to stimulate branched chain amino acid catabolism

线粒体丙酮酸载体抑制引发代谢串扰,刺激支链氨基酸分解代谢

Daniel Ferguson, Sophie J Eichler, Nicole K H Yiew, Jerry R Colca, Kevin Cho, Gary J Patti, Trevor M Shew, Andrew J Lutkewitte, Sandip Mukherjee, Kyle S McCommis, Natalie M Niemi, Brian N Finck