日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Identification of anti-TIM-3 based checkpoint inhibitor combinations with activity in immunotherapy refractory melanoma models

鉴定在免疫疗法难治性黑色素瘤模型中具有活性的基于抗TIM-3的检查点抑制剂组合

Manali S Phadke ,Jiannong Li ,Sathya Sriramareddy ,Paulo C Rodriguez ,Brian Ruffell ,Vincent C Luca ,Thuy T T Tran ,Yian Ann Chen ,Keiran S M Smalley

Interleukin-1α release during necrotic-like cell death generates myeloid-driven immunosuppression that restricts anti-tumor immunity

坏死样细胞死亡过程中释放的白细胞介素-1α会产生髓系驱动的免疫抑制,从而限制抗肿瘤免疫。

Kay Hänggi ,Jie Li ,Achintyan Gangadharan ,Xiaoxian Liu ,Daiana P Celias ,Olabisi Osunmakinde ,Aysenur Keske ,Joshua Davis ,Faiz Ahmad ,Auriane Giron ,Carmen M Anadon ,Alycia Gardner ,David G DeNardo ,Timothy I Shaw ,Amer A Beg ,Xiaoqing Yu ,Brian Ruffell

Macrophage-mediated myelin recycling fuels brain cancer malignancy

巨噬细胞介导的髓鞘再生促进脑癌恶性肿瘤的发生

Daan J Kloosterman ,Johanna Erbani ,Menno Boon ,Martina Farber ,Shanna M Handgraaf ,Masami Ando-Kuri ,Elena Sánchez-López ,Bauke Fontein ,Marjolijn Mertz ,Marja Nieuwland ,Ning Qing Liu ,Gabriel Forn-Cuni ,Nicole N van der Wel ,Anita E Grootemaat ,Luuk Reinalda ,Sander I van Kasteren ,Elzo de Wit ,Brian Ruffell ,Ewa Snaar-Jagalska ,Kevin Petrecca ,Dieta Brandsma ,Alexander Kros ,Martin Giera ,Leila Akkari

Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity

IFNβ 与膜稳定型 CD40L 联合应用可最大程度地激活肿瘤树突状细胞并促进其向淋巴结迁移,从而诱导全身性 T 细胞免疫反应。

Hong Zheng,Xiaoqing Yu,Mohammed L Ibrahim,Dana Foresman,Mengyu Xie,Joseph O Johnson,Theresa A Boyle,Brian Ruffell,Bradford A Perez,Scott J Antonia,Neal Ready,Andreas N Saltos,Mark J Cantwell,Amer A Beg

Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI)

利用人工智能同时分割肺腺癌分级(GLASS-AI)

John H Lockhart, Hayley D Ackerman, Kyubum Lee, Mahmoud Abdalah, Andrew John Davis, Nicole Hackel, Theresa A Boyle, James Saller, Aysenur Keske, Kay Hänggi, Brian Ruffell, Olya Stringfield, W Douglas Cress, Aik Choon Tan, Elsa R Flores

Ablation of the endoplasmic reticulum stress kinase PERK induces paraptosis and type I interferon to promote anti-tumor T cell responses

内质网应激激酶PERK的缺失可诱导副凋亡和I型干扰素,从而促进抗肿瘤T细胞反应。

Jessica K Mandula ,Shiun Chang ,Eslam Mohamed ,Rachel Jimenez ,Rosa A Sierra-Mondragon ,Darwin C Chang ,Alyssa N Obermayer ,Carlos M Moran-Segura ,Satyajit Das ,Julio A Vazquez-Martinez ,Karol Prieto ,Ann Chen ,Keiran S M Smalley ,Brian Czerniecki ,Peter Forsyth ,Richard C Koya ,Brian Ruffell ,Juan R Cubillos-Ruiz ,David H Munn ,Timothy I Shaw ,Jose R Conejo-Garcia ,Paulo C Rodriguez

LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition

LAG3 胞外结构域结构揭示了配体和抗体识别的功能界面

Qianqian Ming, Daiana P Celias, Chao Wu, Aidan R Cole, Srishti Singh, Charlotte Mason, Shen Dong, Timothy H Tran, Gaya K Amarasinghe, Brian Ruffell, Vincent C Luca

TIM-3 blockade enhances IL-12-dependent antitumor immunity by promoting CD8+ T cell and XCR1+ dendritic cell spatial co-localization

TIM-3阻断通过促进CD8+ T细胞和XCR1+ 树突状细胞的空间共定位来增强IL-12依赖性抗肿瘤免疫

Alycia Gardner ,Álvaro de Mingo Pulido ,Kay Hänggi ,Sarah Bazargan ,Alexis Onimus ,Agnieszka Kasprzak ,Jose R Conejo-Garcia ,Katarzyna A Rejniak ,Brian Ruffell

Detection of exogenous DNA uptake by murine dendritic cells

检测小鼠树突状细胞对外部DNA的摄取

Daiana P Celias ,Álvaro de Mingo Pulido ,Brian Ruffell

Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression

肿瘤相关巨噬细胞驱动基质细胞依赖性胶原交联和硬化,从而促进乳腺癌侵袭。

Ori Maller # ,Allison P Drain # ,Alexander S Barrett # ,Signe Borgquist ,Brian Ruffell ,Igor Zakharevich ,Thanh T Pham ,Tina Gruosso ,Hellen Kuasne ,Johnathon N Lakins ,Irene Acerbi ,J Matthew Barnes ,Travis Nemkov ,Aastha Chauhan ,Jessica Gruenberg ,Aqsa Nasir ,Olof Bjarnadottir ,Zena Werb ,Peter Kabos ,Yunn-Yi Chen ,E Shelley Hwang ,Morag Park ,Lisa M Coussens ,Andrew C Nelson ,Kirk C Hansen ,Valerie M Weaver