日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Mutant and Wild-Type RAS Cross-talk and Stoichiometric Deficiencies Are Determinants of Sensitivity to Targeted Therapies in KRASG12R Pancreatic Ductal Adenocarcinoma.

突变型和野生型 RAS 串扰和化学计量缺陷是 KRASG12R 胰腺导管腺癌对靶向治疗敏感性的决定因素。

Kamgar Mandana, Hobbes G Aaron, Davidson Raven, Dorbin Daniel, Herrera Juliannie, Langenheim John F, Burge Rachel A, Aldakkak Mohammed, Conrardy Ryan D, Szabo Aniko, Thalji Sam Z, Mayer Bradley, Grahl Justin J, Chung Brian Y, Phan Alexandria, Thomas James P, Seo Y David, Evans Douglas B, Christians Kathleen K, Erickson Beth, Hall William A, George Ben, Tsai Susan, Lytle Nikki K, Der Channing J, Kurzrock Razelle, McFall Thomas

The microbial tryptophan metabolite indole acts on the gastrointestinal tract to improve glucose homeostasis in a mouse model of diabetes by enhancing GLP-1 secretion and L cell differentiation

微生物色氨酸代谢产物吲哚作用于胃肠道,通过增强GLP-1分泌和L细胞分化,改善糖尿病小鼠模型的葡萄糖稳态。

Phuah, Phyllis; Norton, Mariana; Cheng, Sijing; Roberts, Anna G; Pirri, Daniela; Meyer, Leah; Chung, Pei-En; Dunsterville, Cecilia; Karwowski, Rafal; Lam, Brian Y H; Otsubo, Emile; Aleksashina, Sofia; Gribble, Fiona M; Reimann, Frank; Hanyaloglu, Aylin C; Yeo, Giles S H; Bewick, Gavin A; Jones, Ben; Owen, Bryn; Murphy, Kevin G

Cross-species studies implicate the melanocortin 3 receptor more strongly in the control of pubertal development than energy balance

跨物种研究表明,黑皮质素3受体在青春期发育调控中的作用比能量平衡更强。

Duckett, Katie; McClellan, Alyce; Corbin, Laura J; Cimino, Irene; Elhakeem, Ahmed; Goncalves Soares, Ana; Williamson, Alice; Cross, Eloise; Fairhurst-Hunter, Zammy; Petrovski, Slavé; Rimmington, Debra; Alegre-Díaz, Jesús; Berumen, Jaime; Kuri-Morales, Pablo; Tapia-Conyer, Roberto; Mokrosinski, Jacek; Farooqi, I Sadaf; Rasheed, Asif; Saleheen, Danish; Butterworth, Adam S; Timpson, Nicholas J; Coll, Anthony P; Raffan, Eleanor; Lam, Brian Y H; O'Rahilly, Stephen

Dehydrative formation and biological evaluation of allylic sulfonamides from allylic alcohols using recyclable silica-supported acid catalysts

利用可回收的二氧化硅负载酸催化剂,由烯丙醇脱水生成烯丙基磺酰胺及其生物学评价

Brandeburg, Zachary C; Koster, Kourtney L; Krishnan, Bhavya; Yang, Brian Y; Zhou, Hannah; Sinkwich, Jacob T; Kampmeyer, Patrick M; Sheaff, Robert J; Lamar, Angus A

Myeloid progenitor dysregulation fuels immunosuppressive macrophages in tumours

髓系祖细胞失调促进肿瘤中免疫抑制性巨噬细胞的增殖

Hegde, Samarth; Giotti, Bruno; Soong, Brian Y; Halasz, Laszlo; Le Berichel, Jessica; Schaefer, Maximilian M; Kloeckner, Benoit; Mattiuz, Raphaël; Park, Matthew D; Magen, Assaf; Marks, Adam; Belabed, Meriem; Hamon, Pauline; Chin, Theodore; Troncoso, Leanna; Lee, Juliana J; Fan, Kaili; Ahimovic, Dughan; Bale, Michael J; Nie, Kai; Chung, Grace; D'souza, Darwin; Angeliadis, Krista; Kim-Schulze, Seunghee; Flores, Raja M; Kaufman, Andrew J; Ginhoux, Florent; Buenrostro, Jason D; Josefowicz, Steven Z; Tsankov, Alexander M; Marron, Thomas U; Ma, Sai; Brown, Brian D; Merad, Miriam

A comprehensive spatio-cellular map of the human hypothalamus.

人类下丘脑的综合空间细胞图谱

Tadross John A, Steuernagel Lukas, Dowsett Georgina K C, Kentistou Katherine A, Lundh Sofia, Porniece Marta, Klemm Paul, Rainbow Kara, Hvid Henning, Kania Katarzyna, Polex-Wolf Joseph, Knudsen Lotte Bjerre, Pyke Charles, Perry John R B, Lam Brian Y H, Brüning Jens C, Yeo Giles S H

Canine genome-wide association study identifies DENND1B as an obesity gene in dogs and humans

犬类全基因组关联研究发现 DENND1B 是犬类和人类的肥胖基因。

Wallis, Natalie J; McClellan, Alyce; Mörseburg, Alexander; Kentistou, Katherine A; Jamaluddin, Aqfan; Dowsett, Georgina K C; Schofield, Ellen; Morros-Nuevo, Anna; Saeed, Sadia; Lam, Brian Y H; Sumanasekera, Natasha T; Chan, Justine; Kumar, Sambhavi S; Zhang, Rey M; Wainwright, Jodie F; Dittmann, Marie; Lakatos, Gabriella; Rainbow, Kara; Withers, David; Bounds, Rebecca; Ma, Marcella; German, Alexander J; Ladlow, Jane; Sargan, David; Froguel, Philippe; Farooqi, I Sadaf; Ong, Ken K; Yeo, Giles S H; Tadross, John A; Perry, John R B; Gorvin, Caroline M; Raffan, Eleanor

A cellular and spatial atlas of TP53-associated tissue remodeling defines a multicellular tumor ecosystem in lung adenocarcinoma.

TP53 相关组织重塑的细胞和空间图谱定义了肺腺癌中的多细胞肿瘤生态系统。

Zhao William, Nguyen Thinh T, Bhagwat Atharva, Kumar Akhil, Giotti Bruno, Kepecs Benjamin, Weirather Jason L, Mahadevan Navin R, Segerstolpe Asa, Dolasia Komal, Abdul-Ghafar Jamshid, Besson Naomi R, Jones Stephanie M, Soong Brian Y, Li Chendi, Vigneau Sebastien, Slyper Michal, Wakiro Isaac, Su Mei-Ju, Helvie Karla, Frangieh Allison, Jane-Valbuena Judit, Ashenberg Orr, Awad Mark, Rotem Asaf, Bueno Raphael, Rozenblatt-Rosen Orit, Pfaff Kathleen, Rodig Scott, Hata Aaron N, Regev Aviv, Johnson Bruce E, Tsankov Alexander M

Single-cell image-based screens identify host regulators of Ebola virus infection dynamics.

基于单细胞图像的筛选方法可识别埃博拉病毒感染动态的宿主调控因子。

Carlson Rebecca J, Patten J J, Stefanakis George, Soong Brian Y, Radhakrishnan Adityanarayanan, Singh Avtar, Thakur Naveen, Sheehan Kathleen C F, Amarasinghe Gaya K, Hacohen Nir, Basler Christopher F, Leung Daisy W, Uhler Caroline, Davey Robert A, Blainey Paul C

BiDAC-dependent degradation of plasma membrane proteins by the endolysosomal system.

BiDAC依赖性内溶酶体系统降解质膜蛋白

Villa Sammy, Jafri Qumber, Lazzari-Dean Julia R, Sangha Manjot, Olsson Niclas, Lefebvre Austin E Y T, Fitzgerald Mark E, Jackson Katrina, Chen Zhenghao, Feng Brian Y, Nile Aaron H, Stokoe David, Bersuker Kirill