日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine A(1)-Receptor That Maintains Its Orthosteric Binding Site's Availability to Bind Ligands

两步配体导向的腺苷A(1)受体共价荧光标记法,可保持其正构结合位点与配体结合的能力

Lin, Chia-Yang; Platt, Simon; Goulding, Joelle; Briddon, Stephen J; Kindon, Nicholas D; Harwood, Clare R; Lai, Chih-Wei; Kellam, Barrie; Hill, Stephen J

Agonist efficacy at the β(2)AR is driven by the faster association rate of the G(s) protein.

β(2)AR 激动剂的效力取决于 G(s) 蛋白结合速率的加快

Harwood Clare R, Sykes David A, Redfern-Nichols Theo, Underwood Owen, Nicholson Colin, Khoshgrudi Armin N, Koers Eline J, Ladds Graham, Briddon Stephen J, Veprintsev Dmitry B

Small Molecule Fluorescent Ligands for the Atypical Chemokine Receptor 3 (ACKR3)

非典型趋化因子受体 3 (ACKR3) 的小分子荧光配体

Dekkers, Sebastian; Comez, Dehan; Karsai, Noemi; Arimont-Segura, Marta; Canals, Meritxell; Caspar, Birgit; de Graaf, Chris; Kilpatrick, Laura E; Leurs, Rob; Kellam, Barrie; Hill, Stephen J; Briddon, Stephen J; Stocks, Michael J

Simple methods for quantifying super-resolved cortical actin

量化超高分辨率皮质肌动蛋白的简便方法

Garlick, Evelyn; Faulkner, Emma L; Briddon, Stephen J; Thomas, Steven G

Bitter taste sensitivity in domestic dogs (Canis familiaris) and its relevance to bitter deterrents of ingestion

家犬(Canis familiaris)的苦味敏感性及其与苦味阻隔剂摄入的相关性

Gibbs, Matthew; Winnig, Marcel; Riva, Irene; Dunlop, Nicola; Waller, Daniel; Klebansky, Boris; Logan, Darren W; Briddon, Stephen J; Holliday, Nicholas D; McGrane, Scott J

Efficient G protein coupling is not required for agonist-mediated internalization and membrane reorganization of the adenosine A3 receptor

腺苷 A3 受体激动剂介导的内化和膜重组不需要有效的 G 蛋白偶联

Leigh A Stoddart, Laura E Kilpatrick, Ross Corriden, Barrie Kellam, Stephen J Briddon, Stephen J Hill

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

脂质锚定的神经激肽1受体拮抗剂通过靶向质膜和内体中的受体的三管齐下作用机制来延长镇痛效果。

Mai, Quynh N; Shenoy, Priyank; Quach, Tim; Retamal, Jeffri S; Gondin, Arisbel B; Yeatman, Holly R; Aurelio, Luigi; Conner, Joshua W; Poole, Daniel P; Canals, Meritxell; Nowell, Cameron J; Graham, Bim; Davis, Thomas P; Briddon, Stephen J; Hill, Stephen J; Porter, Christopher J H; Bunnett, Nigel W; Halls, Michelle L; Veldhuis, Nicholas A

Acylation of the Incretin Peptide Exendin-4 Directly Impacts Glucagon-Like Peptide-1 Receptor Signaling and Trafficking

肠促胰岛素肽艾塞那肽-4的酰化作用直接影响胰高血糖素样肽-1受体信号传导和转运

Lucey, Maria; Ashik, Tanyel; Marzook, Amaara; Wang, Yifan; Goulding, Joëlle; Oishi, Atsuro; Broichhagen, Johannes; Hodson, David J; Minnion, James; Elani, Yuval; Jockers, Ralf; Briddon, Stephen J; Bloom, Stephen R; Tomas, Alejandra; Jones, Ben

Detection of genome-edited and endogenously expressed G protein-coupled receptors

检测基因编辑和内源表达的G蛋白偶联受体

Soave, Mark; Stoddart, Leigh A; White, Carl W; Kilpatrick, Laura E; Goulding, Joëlle; Briddon, Stephen J; Hill, Stephen J

Fluorescent ligands: Bringing light to emerging GPCR paradigms

荧光配体:为新兴的GPCR范式带来曙光

Soave, Mark; Briddon, Stephen J; Hill, Stephen J; Stoddart, Leigh A