A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes
脂质锚定的神经激肽1受体拮抗剂通过靶向质膜和内体中的受体的三管齐下作用机制来延长镇痛效果。
期刊:Journal of Biological Chemistry
影响因子:3.9
doi:10.1016/j.jbc.2021.100345
Mai, Quynh N; Shenoy, Priyank; Quach, Tim; Retamal, Jeffri S; Gondin, Arisbel B; Yeatman, Holly R; Aurelio, Luigi; Conner, Joshua W; Poole, Daniel P; Canals, Meritxell; Nowell, Cameron J; Graham, Bim; Davis, Thomas P; Briddon, Stephen J; Hill, Stephen J; Porter, Christopher J H; Bunnett, Nigel W; Halls, Michelle L; Veldhuis, Nicholas A