日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

VX-445 (elexacaftor) inhibits chloride secretion across human bronchial epithelial cells by directly blocking KCa3.1 channels

VX-445(依来卡托)通过直接阻断KCa3.1通道抑制人支气管上皮细胞的氯离子分泌。

Kolski-Andreaco, Aaron; Balut, Corina M; Green, Matthew D; Sembrat, John; Bridges, Robert J; Singh, Ashvani K; Tse, Chris; Butterworth, Michael B; Devor, Daniel C

Potentiation of BKCa channels by cystic fibrosis transmembrane conductance regulator correctors VX-445 and VX-121.

囊性纤维化跨膜电导调节剂 VX-445 和 VX-121 可增强 BKCa 通道

Kolski-Andreaco Aaron, Taiclet Stefanie, Myerburg Michael M, Sembrat John, Bridges Robert J, Straub Adam C, Wills Zachary P, Butterworth Michael B, Devor Daniel C

Systematic deletion of symmetrical CFTR exons reveals new therapeutic targets for exon skipping antisense oligonucleotides

系统性删除对称性CFTR外显子揭示了外显子跳跃反义寡核苷酸的新治疗靶点

Pena-Rasgado, Cecilia; Rodriguez-Manriquez, Elvia; Dundr, Miroslav; Bridges, Robert J; Hastings, Michelle L; Michaels, Wren E

Integrative chemogenomic analysis identifies small molecules that partially rescue ΔF508-CFTR for cystic fibrosis

整合化学基因组学分析鉴定出可部分挽救囊性纤维化ΔF508-CFTR的小分子

Hodos, Rachel A; Strub, Matthew D; Ramachandran, Shyam; Meleshkevitch, Ella A; Boudko, Dmitri Y; Bridges, Robert J; Dudley, Joel T; McCray, Paul B Jr

Sphingomyelinase decreases transepithelial anion secretion in airway epithelial cells in part by inhibiting CFTR-mediated apical conductance

鞘磷脂酶通过抑制CFTR介导的顶端电导,部分降低气道上皮细胞的跨上皮阴离子分泌。

Cottrill, Kirsten A; Peterson, Raven J; Lewallen, Colby F; Koval, Michael; Bridges, Robert J; McCarty, Nael A

Mechanistic analysis and significance of sphingomyelinase-mediated decreases in transepithelial CFTR currents in nHBEs

鞘磷脂酶介导的nHBE跨上皮CFTR电流降低的机制分析及其意义

Cottrill, Kirsten A; Giacalone, Vincent D; Margaroli, Camilla; Bridges, Robert J; Koval, Michael; Tirouvanziam, Rabindra; McCarty, Nael A

Antisense oligonucleotide-mediated correction of CFTR splicing improves chloride secretion in cystic fibrosis patient-derived bronchial epithelial cells

反义寡核苷酸介导的CFTR剪接校正可改善囊性纤维化患者来源支气管上皮细胞的氯离子分泌

Michaels, Wren E; Bridges, Robert J; Hastings, Michelle L

CFTR modulator theratyping: Current status, gaps and future directions

CFTR调节因子治疗分型:现状、差距和未来方向

Clancy, John Paul; Cotton, Calvin U; Donaldson, Scott H; Solomon, George M; VanDevanter, Donald R; Boyle, Michael P; Gentzsch, Martina; Nick, Jerry A; Illek, Beate; Wallenburg, John C; Sorscher, Eric J; Amaral, Margarida D; Beekman, Jeffrey M; Naren, Anjaparavanda P; Bridges, Robert J; Thomas, Philip J; Cutting, Garry; Rowe, Steven; Durmowicz, Anthony G; Mense, Martin; Boeck, Kris D; Skach, William; Penland, Christopher; Joseloff, Elizabeth; Bihler, Hermann; Mahoney, John; Borowitz, Drucy; Tuggle, Katherine L

Evidence against resveratrol as a viable therapy for the rescue of defective ΔF508 CFTR

证据表明,白藜芦醇并非治疗缺陷型ΔF508 CFTR的有效疗法。

Jai, Ying; Shah, Kalpit; Bridges, Robert J; Bradbury, Neil A

Effect of apical hyperosmotic sodium challenge and amiloride on sodium transport in human bronchial epithelial cells from cystic fibrosis donors

顶端高渗钠刺激和阿米洛利对囊性纤维化供体人支气管上皮细胞钠转运的影响

Rasgado-Flores, Hector; Krishna Mandava, Vamsi; Siman, Homayoun; Van Driessche, Willy; Pilewski, Joseph M; Randell, Scott H; Bridges, Robert J