日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Discovery of VU6025733 (AG06827): A Highly Selective, Orally Bioavailable, and Structurally Distinct M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM) with Robust In Vivo Efficacy

VU6025733 (AG06827) 的发现:一种高选择性、口服生物利用度高、结构独特的 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM),具有强大的体内疗效

Gregro, Alison R; Park, Charlotte; Long, Madeline F; Baker, Logan A; Bollinger, Katrina A; Ringuette, Anna E; Peng, Li; Luscombe, Vincent B; Billard, Natasha B; Rodriguez, Alice L; Niswender, Colleen M; Peng, Weimin; Dickerson, Jonathan W; Rook, Jerri M; O'Neill, Jordan; Chang, Sichen; Boonen, Harrie C M; Jensen, Thomas; Thomsen, Morten S; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Optimization of Selective and CNS Penetrant Alkyne-Based TREK Inhibitors: The Discovery and Characterization of ONO-9517601 (VU6022856) and ONO-7927846 (VU6024391)

选择性和中枢神经系统渗透性炔基TREK抑制剂的优化:ONO-9517601 (VU6022856) 和 ONO-7927846 (VU6024391) 的发现和表征

Tanaka, Motoyuki; Sekioka, Yoko; Hashimoto, Gakuji; Mori, Takahiro; Shono, Tomoyuki; Isaji, Yuuki; Hisaichi, Katsuya; Childress, Elizabeth S; Bollinger, Sean; Schmitt, Joza A; Chopko, Trevor C; Garrison, Aaron T; Perry, Charles K; Chronister, Keagan; Kramer, Meghan; Chang, Sichen; Watson, Katherine J; Dickerson, Jonathan W; Bubser, Michael; Rook, Jerri M; Jones, Carrie K; Boutaud, Olivier; Bridges, Thomas M; Denton, Jerod S; Engers, Darren W; Kurata, Haruto; Lindsley, Craig W

Discovery of ONO-TR-772 (VU6018042): A Highly Selective and CNS Penetrant TREK Inhibitor in Vivo Tool Compound

ONO-TR-772 (VU6018042) 的发现:一种高选择性且能穿透中枢神经系统的 TREK 抑制剂体内工具化合物

Tanaka, Motoyuki; Mori, Takahiro; Hashimoto, Gakuji; Mitsui, Katsukuni; Kishi, Akihiro; Childress, Elizabeth S; Bollinger, Sean R; Chopko, Trevor C; Bridges, Thomas M; Stafford, Douglas G; Huang, Zhonping; Wolf, Mark A; Engers, Darren W; Denton, Jerod S; Kurata, Haruto; Lindsley, Craig W

Correction to "Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound"

对“ONO-2920632 (VU6011887) 的发现:一种高选择性且能穿透中枢神经系统的 TREK-2 (TWIK 相关 K+ 通道 2) 优先激活剂体内工具化合物”的更正

Yashiro, Kentaro; Iwaki, Yuzo; Urata, Hirohito; Kokubo, Masaya; Mori, Takahiro; Sekioka, Yoko; Isami, Koichi; Kato, Junya; Wieting, Joshua; McGowan, Kevin M; Bridges, Thomas M; Boutaud, Olivier; Engers, Darren W; Denton, Jerod S; Kurata, Haruto; Lindsley, Craig W

Discovery of VU0467319: an M(1) Positive Allosteric Modulator Candidate That Advanced into Clinical Trials

VU0467319 的发现:一种进入临床试验的 M(1) 正向变构调节剂候选药物

Poslunsey, Michael S; Wood, Michael R; Han, Changho; Stauffer, Shaun R; Panarese, Joseph D; Melancon, Bruce J; Engers, Julie L; Dickerson, Jonathan W; Peng, Weimin; Noetzel, Meredith J; Cho, Hyekyung P; Rodriguez, Alice L; Hopkins, Corey R; Morrison, Ryan; Crouch, Rachel D; Bridges, Thomas M; Blobaum, Anna L; Boutaud, Olivier; Daniels, J Scott; Kates, Michael J; Castelhano, Arlindo; Rook, Jerri M; Niswender, Colleen M; Jones, Carrie K; Conn, P Jeffrey; Lindsley, Craig W

Discovery of ONO-2920632 (VU6011887): A Highly Selective and CNS Penetrant TREK-2 (TWIK-Related K+ Channel 2) Preferring Activator In Vivo Tool Compound

ONO-2920632 (VU6011887) 的发现:一种高选择性且能穿透中枢神经系统的 TREK-2 (TWIK 相关钾离子通道 2) 优先激活剂的体内工具化合物

Yashiro, Kentaro; Iwaki, Yuzo; Urata, Hirohito; Kokubo, Masaya; Mori, Takahiro; Sekioka, Yoko; Isami, Koichi; Kato, Junya; Wieting, Joshua; McGowan, Kevin M; Bridges, Thomas M; Boutaud, Olivier; Engers, Darren W; Denton, Jerod S; Kurata, Haruto; Lindsley, Craig W

Discovery of VU6008677: A Structurally Distinct Tricyclic M(4) Positive Allosteric Modulator with Improved CYP450 Profile

VU6008677 的发现:一种结构独特的 M(4) 三环正变构调节剂,具有改进的 CYP450 活性

Capstick, Rory A; Bollinger, Sean R; Engers, Julie L; Long, Madeline F; Chang, Sichen; Luscombe, Vincent B; Rodriguez, Alice L; Niswender, Colleen M; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M(4) Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM)

VU6016235 的发现:一种高选择性、口服生物利用度高且结构独特的三环 M(4) 毒蕈碱乙酰胆碱受体正向变构调节剂 (PAM)

Engers, Julie L; Baker, Logan A; Chang, Sichen; Luscombe, Vincent B; Rodriguez, Alice L; Niswender, Colleen M; Cho, Hyekyung P; Bubser, Michael; Gray, Analisa Thompson; Jones, Carrie K; Peng, Weimin; Rook, Jerri M; Bridges, Thomas M; Boutaud, Olivier; Conn, P Jeffrey; Engers, Darren W; Lindsley, Craig W; Temple, Kayla J

Clinical recommendations for polygenic risk score-enhanced breast cancer screening: Can.Heal project

基于多基因风险评分的乳腺癌筛查临床建议:Can.Heal 项目

Bubser, Michael; Bridges, Thomas M; Dencker, Ditte; Gould, Robert W; Grannan, Michael; Noetzel, Meredith J; Lamsal, Atin; Niswender, Colleen M; Daniels, J Scott; Poslusney, Michael S; Melancon, Bruce J; Tarr, James C; Byers, Frank W; Wess, Jürgen; Duggan, Mark E; Dunlop, John; Wood, Michael W; Brandon, Nicholas J; Wood, Michael R; Lindsley, Craig W; Conn, P Jeffrey; Jones, Carrie K; Taha, A; Matt McCrary, J; van Rooij, J; Lahousse, L; Paoletti, F; Pascucci, E; Vaht, M; Pastorino, R; Pezzullo, A M; Boccia, S

Evaluation of intravitreal topotecan dose levels, toxicity and efficacy for retinoblastoma vitreous seeds: a preclinical and clinical study

评估玻璃体内注射拓扑替康治疗视网膜母细胞瘤玻璃体播散的剂量水平、毒性和疗效:一项临床前和临床研究

Bogan, Carley M; Kaczmarek, Jessica V; Pierce, Janene M; Chen, Sheau-Chiann; Boyd, Kelli L; Calcutt, Marion W; Bridges, Thomas M; Lindsley, Craig W; Nadelmann, Jennifer B; Liao, Albert; Hsieh, Terry; Abramson, David H; Francis, Jasmine H; Friedman, Debra L; Richmond, Ann; Daniels, Anthony B