日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Unbiased discovery of cancer pathways and therapeutics using Pathway Ensemble Tool and Benchmark

利用通路集成工具和基准测试进行无偏倚的癌症通路和治疗方法发现

Wang, Luopin; Pattnaik, Aryamav; Sahoo, Subhransu Sekhar; Stone, Ella G; Zhuang, Yuxin; Benton, Annaleigh; Tajmul, Md; Chakravorty, Srishti; Dhawan, Deepika; Nguyen, My An; Sirit, Isabella; Mundy, Kyle; Ricketts, Christopher J; Hadisurya, Marco; Baral, Garima; Tinsley, Samantha L; Anderson, Nicole L; Hoda, Smriti; Briggs, Scott D; Kaimakliotis, Hristos Z; Allen-Petersen, Brittany L; Tao, W Andy; Linehan, W Marston; Knapp, Deborah W; Hanna, Jason A; Olson, Matthew R; Afzali, Behdad; Kazemian, Majid

Candida glabrata maintains two HAP1 ohnologs, HAP1A and HAP1B, for distinct roles in ergosterol gene regulation to mediate sterol homeostasis under azole and hypoxic conditions.

光滑念珠菌维持着两个 HAP1 同源物,即 HAP1A 和 HAP1B,它们在麦角甾醇基因调控中发挥着不同的作用,从而在唑类和缺氧条件下介导甾醇稳态

Saha Debasmita, Gregor Justin B, Hoda Smriti, Eastman Katharine E, Gutierrez-Schultz Victor A, Navarrete Mindy, Wisecaver Jennifer H, Briggs Scott D

Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4

组蛋白H3 K36甲基化是由涉及Set2和组蛋白H4相互作用的跨组蛋白甲基化途径介导的。

Du, Hai-Ning; Fingerman, Ian M; Briggs, Scott D

A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway.

组蛋白 H4 和 Dot1 之间的电荷相互作用是 H3K79 甲基化和端粒沉默所必需的:一种新的跨组蛋白途径的发现

Fingerman Ian M, Li Hui-Chun, Briggs Scott D

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36

在酿酒酵母中进行的全蛋白质组分析发现,几个PHD指状结构域是组蛋白H3在赖氨酸4或赖氨酸36位点甲基化的新型直接选择性结合模块。

Shi, Xiaobing; Kachirskaia, Ioulia; Walter, Kay L; Kuo, Jen-Hao A; Lake, Aimee; Davrazou, Foteini; Chan, Steve M; Martin, David G E; Fingerman, Ian M; Briggs, Scott D; Howe, LeAnn; Utz, Paul J; Kutateladze, Tatiana G; Lugovskoy, Alexey A; Bedford, Mark T; Gozani, Or

Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae

酿酒酵母中Set1介导的H3 Lys4三甲基化的整体缺失与基因沉默缺陷相关

Fingerman, Ian M; Wu, Chia-Ling; Wilson, Bradley D; Briggs, Scott D