日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Early intervention anti-Aβ immunotherapy attenuates microglial activation without inducing exhaustion at residual plaques

早期干预抗Aβ免疫疗法可减轻小胶质细胞活化,而不会导致残余斑块处的细胞耗竭。

Lis de Weerd ,Selina Hummel ,Stephan A Müller ,Iñaki Paris ,Thomas Sandmann ,Marie Eichholtz ,Robin Gröger ,Amelie L Englert ,Stephan Wagner ,Connie Ha ,Sonnet S Davis ,Valerie Warkins ,Dan Xia ,Brigitte Nuscher ,Anna Berghofer ,Marvin Reich ,Astrid F Feiten ,Kai Schlepckow ,Michael Willem ,Stefan F Lichtenthaler ,Joseph W Lewcock ,Kathryn M Monroe ,Matthias Brendel ,Christian Haass

Distinct regulation of Tau Monomer and aggregate uptake and intracellular accumulation in human neurons

Tau 单体和聚集体在人类神经元中的吸收和细胞内积累的独特调节

Amir T Marvian, Tabea Strauss, Qilin Tang, Benjamin J Tuck, Sophie Keeling, Daniel Rüdiger, Negar Mirzazadeh Dizaji, Hossein Mohammad-Beigi, Brigitte Nuscher, Pijush Chakraborty, Duncan S Sutherland, William A McEwan, Thomas Köglsperger, Stefan Zahler, Markus Zweckstetter, Stefan F Lichtenthaler, Wo

Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits

内源性 TDP-43 的错误定位导致类似 ALS 的早期代谢功能障碍和进行性运动障碍

Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

Targeting the glycine-rich domain of TDP-43 with antibodies prevents its aggregation in vitro and reduces neurofilament levels in vivo

利用抗体靶向 TDP-43 富含甘氨酸的结构域可防止其在体外聚集,并降低体内神经丝水平

Henrick Riemenschneider, Francesca Simonetti #, Udit Sheth #, Eszter Katona #, Stefan Roth, Saskia Hutten, Daniel Farny, Meike Michaelsen, Brigitte Nuscher, Michael K Schmidt, Andrew Flatley, Aloys Schepers, Lara A Gruijs da Silva, Qihui Zhou, Thomas Klopstock, Arthur Liesz, Thomas Arzberger, Jochen

Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency

TREM2 的缺失可以挽救小胶质细胞的过度激活,但不能挽救前粒蛋白缺乏模型中的溶酶体功能障碍和神经毒性。

Anika Reifschneider ,Sophie Robinson ,Bettina van Lengerich ,Johannes Gnörich ,Todd Logan ,Steffanie Heindl ,Miriam A Vogt ,Endy Weidinger ,Lina Riedl ,Karin Wind ,Artem Zatcepin ,Ida Pesämaa ,Sophie Haberl ,Brigitte Nuscher ,Gernot Kleinberger ,Julien Klimmt ,Julia K Götzl ,Arthur Liesz ,Katharina Bürger ,Matthias Brendel ,Johannes Levin ,Janine Diehl-Schmid ,Jung Suh ,Gilbert Di Paolo ,Joseph W Lewcock ,Kathryn M Monroe ,Dominik Paquet ,Anja Capell ,Christian Haass

The porphyrin TMPyP4 inhibits elongation during the noncanonical translation of the FTLD/ALS-associated GGGGCC repeat in the C9orf72 gene

卟啉 TMPyP4 可抑制 C9orf72 基因中 FTLD/ALS 相关 GGGGCC 重复序列的非规范翻译过程中的延长

Kohji Mori, Shiho Gotoh, Tomoko Yamashita, Ryota Uozumi, Yuya Kawabe, Shinji Tagami, Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian Haass, Yoshitaka Nagai, Manabu Ikeda

Poly-glycine-alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3

聚甘氨酸-丙氨酸通过隔离磷酸化的 ATM 和丢失核 hnRNPA3 加剧 C9orf72 重复扩增介导的 DNA 损伤

Yoshihiro Nihei, Kohji Mori, Georg Werner, Thomas Arzberger, Qihui Zhou, Barham Khosravi, Julia Japtok, Andreas Hermann, Andreas Sommacal, Markus Weber; German Consortium for Frontotemporal Lobar Degeneration; Bavarian Brain Banking Alliance; Frits Kamp, Brigitte Nuscher, Dieter Edbauer, Christian H

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

利用靶向柄部的双功能TREM2抗体增强小胶质细胞的保护活性

Kai Schlepckow #,Kathryn M Monroe #,Gernot Kleinberger #,Ludovico Cantuti-Castelvetri,Samira Parhizkar,Dan Xia,Michael Willem,Georg Werner,Nadine Pettkus,Bettina Brunner,Alice Sülzen,Brigitte Nuscher,Heike Hampel,Xianyuan Xiang,Regina Feederle,Sabina Tahirovic,Joshua I Park,Rachel Prorok,Cathal Mahon,Chun-Chi Liang,Ju Shi,Do Jin Kim,Hanna Sabelström,Fen Huang,Gilbert Di Paolo,Mikael Simons,Joseph W Lewcock,Christian Haass

Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model

主动 poly-GA 疫苗接种可预防 C9orf72 小鼠模型中的小胶质细胞活化和运动障碍

Qihui Zhou, Nikola Mareljic, Meike Michaelsen, Samira Parhizkar, Steffanie Heindl, Brigitte Nuscher, Daniel Farny, Mareike Czuppa, Carina Schludi, Alexander Graf, Stefan Krebs, Helmut Blum, Regina Feederle, Stefan Roth, Christian Haass, Thomas Arzberger, Arthur Liesz, Dieter Edbauer

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

TREM2 功能丧失会增加淀粉样蛋白的播种,但会降低斑块相关的 ApoE

Samira Parhizkar, Thomas Arzberger, Matthias Brendel, Gernot Kleinberger, Maximilian Deussing, Carola Focke, Brigitte Nuscher, Monica Xiong, Alireza Ghasemigharagoz, Natalie Katzmarski, Susanne Krasemann, Stefan F Lichtenthaler, Stephan A Müller, Alessio Colombo, Laura Sebastian Monasor, Sabina Tahi