Reduced susceptibility of Haemophilus influenzae to the peptide deformylase inhibitor LBM415 can result from target protein overexpression due to amplified chromosomal def gene copy number
由于染色体 def 基因拷贝数扩增导致靶蛋白过度表达，流感嗜血杆菌对肽脱甲酰酶抑制剂 LBM415 的敏感性降低
期刊:Antimicrobial Agents and Chemotherapy
影响因子:4.1
doi:10.1128/AAC.01103-06
Charles R Dean, Shubha Narayan, Joel Richards, Denis M Daigle, Stacy Esterow, Jennifer A Leeds, Heather Kamp, Xiaoling Puyang, Brigitte Wiedmann, Dieter Mueller, Hans Voshol, Jan van Oostrum, Daniel Wall, James Koehn, Joann Dzink-Fox, Neil S Ryder
