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Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment

乳腺肿瘤转移及其微环境：肿瘤的生长和治疗靶向都需要种子和土壤

Bonni, Shirin; Brindley, David N; Chamberlain, M Dean; Daneshvar-Baghbadorani, Nima; Freywald, Andrew; Hemmings, Denise G; Hombach-Klonisch, Sabine; Klonisch, Thomas; Raouf, Afshin; Shemanko, Carrie Simone; Topolnitska, Diana; Visser, Kaitlyn; Vizeacoumar, Franco J; Wang, Edwin; Gibson, Spencer B

肿瘤

肿瘤免疫

发表日期：2024

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Insights into autotaxin- and lysophosphatidate-mediated signaling in the pancreatic ductal adenocarcinoma tumor microenvironment: a survey of pathway gene expression

胰腺导管腺癌肿瘤微环境中自泌素和溶血磷脂酸介导的信号通路研究：通路基因表达分析

期刊:American Journal of Cancer Research

影响因子:2.9

doi:10.62347/KQNW1871

Benesch, Matthew Gk; Wu, Rongrong; Rog, Colin J; Brindley, David N; Ishikawa, Takashi; Takabe, Kazuaki

Late Breaking Abstracts for ECO 2024

ECO 2024 最新摘要

期刊:Cell Biochemistry and Biophysics

影响因子:2.5

doi:10.1007/s12013-021-01024-6

Venkatraman, Ganesh; Tang, Xiaoyun; Du, Guangwei; Parisentti, Amadeo M; Hemmings, Denise G; Brindley, David N

发表日期：2024

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Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer

自泌素和溶血磷脂酸信号通路：缓解乳腺癌治疗耐药性的主要靶点

期刊:World Journal of Oncology

影响因子:2.2

doi:10.14740/wjon1762

Benesch, Matthew G K; Tang, Xiaoyun; Brindley, David N; Takabe, Kazuaki

Lysophosphatidic Acid Receptor Signaling in the Human Breast Cancer Tumor Microenvironment Elicits Receptor-Dependent Effects on Tumor Progression

溶血磷脂酸受体信号在人乳腺癌肿瘤微环境中引发受体依赖性肿瘤进展效应

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms24129812

Benesch, Matthew G K; Wu, Rongrong; Tang, Xiaoyun; Brindley, David N; Ishikawa, Takashi; Takabe, Kazuaki

Infliximab, a Monoclonal Antibody against TNF-α, Inhibits NF-κB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs

英夫利昔单抗是一种抗TNF-α的单克隆抗体，可抑制NF-κB活化、自泌素表达和乳腺癌肺转移。

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers16010052

Shinde, Anjali; Tang, Xiaoyun; Singh, Rajesh; Brindley, David N

Decreased Lipid Phosphate Phosphatase 1/3 and Increased Lipid Phosphate Phosphatase 2 Expression in the Human Breast Cancer Tumor Microenvironment Promotes Tumor Progression and Immune System Evasion

人乳腺癌肿瘤微环境中脂质磷酸磷酸酶1/3表达降低和脂质磷酸磷酸酶2表达升高促进肿瘤进展和免疫逃逸

期刊:Cancers

影响因子:4.4

doi:10.3390/cancers15082299

Benesch, Matthew G K; Wu, Rongrong; Tang, Xiaoyun; Brindley, David N; Ishikawa, Takashi; Takabe, Kazuaki

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

PDGFRα增强人巨细胞病毒对乳腺癌细胞的感染，但对成纤维细胞的感染则增加涉及溶血磷脂酸信号传导的促转移炎症

期刊:International Journal of Molecular Sciences

影响因子:4.9

doi:10.3390/ijms22189817

Yang, Zelei; Tang, Xiaoyun; McMullen, Todd P W; Brindley, David N; Hemmings, Denise G

Immunology/Inflammation

FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival

FOXQ1在不同乳腺癌亚型中差异表达，低表达与较差的总体生存率相关。

期刊:Breast Cancer-Targets and Therapy

影响因子:3.4

doi:10.2147/BCTT.S282860

Elian, Fahed A; Are, Ubah; Ghosh, Sunita; Nuin, Paulo; Footz, Tim; McMullen, Todd P W; Brindley, David N; Walter, Michael A

Inhibition of autotaxin activity with IOA-289 decreases fibrosis in mouse E0771 breast tumors.

用 IOA-289 抑制自泌素活性可减少小鼠 E0771 乳腺肿瘤的纤维化

Breast Tumor Metastasis and Its Microenvironment: It Takes Both Seed and Soil to Grow a Tumor and Target It for Treatment

乳腺肿瘤转移及其微环境：肿瘤的生长和治疗靶向都需要种子和土壤

Insights into autotaxin- and lysophosphatidate-mediated signaling in the pancreatic ductal adenocarcinoma tumor microenvironment: a survey of pathway gene expression

胰腺导管腺癌肿瘤微环境中自泌素和溶血磷脂酸介导的信号通路研究：通路基因表达分析

Late Breaking Abstracts for ECO 2024

ECO 2024 最新摘要

Autotaxin and Lysophosphatidate Signaling: Prime Targets for Mitigating Therapy Resistance in Breast Cancer

自泌素和溶血磷脂酸信号通路：缓解乳腺癌治疗耐药性的主要靶点

Lysophosphatidic Acid Receptor Signaling in the Human Breast Cancer Tumor Microenvironment Elicits Receptor-Dependent Effects on Tumor Progression

溶血磷脂酸受体信号在人乳腺癌肿瘤微环境中引发受体依赖性肿瘤进展效应

Infliximab, a Monoclonal Antibody against TNF-α, Inhibits NF-κB Activation, Autotaxin Expression and Breast Cancer Metastasis to Lungs

英夫利昔单抗是一种抗TNF-α的单克隆抗体，可抑制NF-κB活化、自泌素表达和乳腺癌肺转移。

Decreased Lipid Phosphate Phosphatase 1/3 and Increased Lipid Phosphate Phosphatase 2 Expression in the Human Breast Cancer Tumor Microenvironment Promotes Tumor Progression and Immune System Evasion

人乳腺癌肿瘤微环境中脂质磷酸磷酸酶1/3表达降低和脂质磷酸磷酸酶2表达升高促进肿瘤进展和免疫逃逸

PDGFRα Enhanced Infection of Breast Cancer Cells with Human Cytomegalovirus but Infection of Fibroblasts Increased Prometastatic Inflammation Involving Lysophosphatidate Signaling

PDGFRα增强人巨细胞病毒对乳腺癌细胞的感染，但对成纤维细胞的感染则增加涉及溶血磷脂酸信号传导的促转移炎症

FOXQ1 is Differentially Expressed Across Breast Cancer Subtypes with Low Expression Associated with Poor Overall Survival

FOXQ1在不同乳腺癌亚型中差异表达，低表达与较差的总体生存率相关。