日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Safety, tolerability, and immunogenicity of INO-4500, a synthetic DNA-based vaccine against Lassa virus, in a phase 1b clinical trial in healthy Ghanaian adults

在加纳健康成年人中开展的 1b 期临床试验中,研究人员评估了 INO-4500(一种合成 DNA 疫苗,用于预防拉沙病毒)的安全性、耐受性和免疫原性。

Koram, Kwadwo Ansah; Walker, Kathleen A; Orizu, Bonaventure; Marrero, Idania; Boyer, Jean; Yang, ShuPing; Broderick, Kate E; Kusi, Kwadwo Asamoah; Kyei-Baafour, Eric; Ofori, Ebenezer Addo; Pobee, Abigail; Adu-Amankwah, Susan; Amoakoh-Coleman, Mary; Amoakoh, Hannah Brown; Abuaku, Benjamin; Badji, Edem; Ntiri, Michael; Quaye, Lydia; Morrow, Matthew P; Sylvester, Albert J; Reuschel, Emma L; Gillespie, Elisabeth; Liebowitz, David; Humeau, Laurent M

Safety, tolerability, and immunogenicity of a DNA-based vaccine (INO-4700) against Middle East respiratory syndrome coronavirus: phase 2a study in healthy volunteers

DNA疫苗(INO-4700)对抗中东呼吸综合征冠状病毒的安全性、耐受性和免疫原性:健康志愿者中的2a期研究

Agnes, Joseph T; Marcus, Sarah A; Al-Ghraibeh, Sahem S; Al-Sweedan, Suleimman Ahmad; Kosgei, Josphat; Ogutu, Bernhards; Yang, ShuPing; Walker, Kathleen A; Orizu, Bonaventure; Broderick, Kate E; Boyer, Jean; Ramos, Stephanie; Morrow, Matthew P; Kraynyak, Kimberly; Sylvester, Albert J; Gillespie, Elisabeth; Liebowitz, David; Humeau, Laurent M

Safety and immunogenicity of INO-4800 DNA vaccine against SARS-CoV-2: A preliminary report of an open-label, Phase 1 clinical trial.

INO-4800 DNA疫苗对SARS-CoV-2的安全性和免疫原性:一项开放标签1期临床试验的初步报告

Tebas Pablo, Yang ShuPing, Boyer Jean D, Reuschel Emma L, Patel Ami, Christensen-Quick Aaron, Andrade Viviane M, Morrow Matthew P, Kraynyak Kimberly, Agnes Joseph, Purwar Mansi, Sylvester Albert, Pawlicki Jan, Gillespie Elisabeth, Maricic Igor, Zaidi Faraz I, Kim Kevin Y, Dia Yaya, Frase Drew, Pezzoli Patrick, Schultheis Katherine, Smith Trevor R F, Ramos Stephanie J, McMullan Trevor, Buttigieg Karen, Carroll Miles W, Ervin John, Diehl Malissa C, Blackwood Elliott, Mammen Mammen P, Lee Jessica, Dallas Michael J, Brown Ami Shah, Shea Jacqueline E, Kim J Joseph, Weiner David B, Broderick Kate E, Humeau Laurent M

Intradermal delivery of a synthetic DNA vaccine protects macaques from Middle East respiratory syndrome coronavirus

皮内注射合成DNA疫苗可保护猕猴免受中东呼吸综合征冠状病毒感染

Patel, Ami; Reuschel, Emma L; Xu, Ziyang; Zaidi, Faraz I; Kim, Kevin Y; Scott, Dana P; Mendoza, Janess; Ramos, Stephanie; Stoltz, Regina; Feldmann, Friederike; Okumura, Atsushi; Meade-White, Kimberly; Haddock, Elaine; Thomas, Tina; Rosenke, Rebecca; Lovaglio, Jamie; Hanley, Patrick W; Saturday, Greg; Muthumani, Kar; Feldmann, Heinz; Humeau, Laurent M; Broderick, Kate E; Weiner, David B

Live Virus Neutralisation of the 501Y.V1 and 501Y.V2 SARS-CoV-2 Variants following INO-4800 Vaccination of Ferrets

雪貂接种 INO-4800 疫苗后,501Y.V1 和 501Y.V2 SARS-CoV-2 变种的活病毒中和作用

Riddell, Shane; Goldie, Sarah; McAuley, Alexander J; Kuiper, Michael J; Durr, Peter A; Blasdell, Kim R; Tachedjian, Mary; Druce, Julian D; Smith, Trevor R F; Broderick, Kate E; Vasan, Seshadri S

One or two dose regimen of the SARS-CoV-2 synthetic DNA vaccine INO-4800 protects against respiratory tract disease burden in nonhuman primate challenge model.

SARS-CoV-2 合成 DNA 疫苗 INO-4800 的一剂或两剂方案可在非人灵长类动物攻毒模型中预防呼吸道疾病负担

Gooch Karen E, Smith Trevor R F, Salguero Francisco J, Fotheringham Susan A, Watson Robert J, Dennis Mike J, Handley Alastair, Humphries Holly E, Longet Stephanie, Tipton Tom, Sarfas Charlotte, Sibley Laura, Slack Gillian S, Rayner Emma, Ryan Kathryn A, Schultheis Katherine, Ramos Stephanie J, White Andrew, Charlton Sue, Sharpe Sally A, Gleeson Fergus, Humeau Laurent M, Hall Yper, Broderick Kate E, Carroll Miles W

Nanoparticle Vaccines: In Vivo Assembly of Nanoparticles Achieved through Synergy of Structure‐Based Protein Engineering and Synthetic DNA Generates Enhanced Adaptive Immunity (Adv. Sci. 8/2020)

纳米颗粒疫苗:通过基于结构的蛋白质工程和合成DNA的协同作用实现纳米颗粒的体内组装,从而增强适应性免疫(Adv. Sci. 8/2020)

Townsend, E Andrew; Bremer, Paul T; Faunce, Kaycee E; Negus, S Stevens; Jaster, Alaina M; Robinson, Hannah L; Janda, Kim D; Banks, Matthew L; Xu, Ziyang; Wise, Megan C; Chokkalingam, Neethu; Walker, Susanne; Tello‐Ruiz, Edgar; Elliott, Sarah T C; Perales‐Puchalt, Alfredo; Xiao, Peng; Zhu, Xizhou; Pumroy, Ruth A; Fisher, Paul D; Schultheis, Katherine; Schade, Eric; Menis, Sergey; Guzman, Stacy; Andersen, Hanne; Broderick, Kate E; Humeau, Laurent M; Muthumani, Kar; Moiseenkova‐Bell, Vera; Schief, William R; Weiner, David B; Kulp, Daniel W

Immunotherapy with DNA vaccine and live attenuated rubella/SIV gag vectors plus early ART can prevent SIVmac251 viral rebound in acutely infected rhesus macaques

采用DNA疫苗和减毒活风疹/SIV gag载体进行免疫治疗,并尽早进行抗逆转录病毒治疗,可以预防急性感染SIVmac251的恒河猴体内病毒反弹。

Virnik, Konstantin; Rosati, Margherita; Medvedev, Alexei; Scanlan, Aaron; Walsh, Gabrielle; Dayton, Frances; Broderick, Kate E; Lewis, Mark; Bryson, Yvonne; Lifson, Jeffrey D; Ruprecht, Ruth M; Felber, Barbara K; Berkower, Ira

Active Immunoprophylaxis and Vaccine Augmentations Mediated by a Novel Plasmid DNA Formulation

新型质粒DNA制剂介导的主动免疫预防和疫苗增强作用

Schommer, Nina N; Nguyen, Jacklyn; Yung, Bryan S; Schultheis, Katherine; Muthumani, Kar; Weiner, David B; Humeau, Laurent; Broderick, Kate E; Smith, Trevor R F

Synthetic DNA-Encoded Monoclonal Antibody Delivery of Anti-CTLA-4 Antibodies Induces Tumor Shrinkage In Vivo

合成DNA编码的单克隆抗体递送抗CTLA-4抗体可诱导体内肿瘤缩小

Duperret, Elizabeth K; Trautz, Aspen; Stoltz, Regina; Patel, Ami; Wise, Megan C; Perales-Puchalt, Alfredo; Smith, Trevor; Broderick, Kate E; Masteller, Emma; Kim, J Joseph; Humeau, Laurent; Muthumani, Kar; Weiner, David B