日期:
2020 年 — 2026 年
2020
2021
2022
2023
2024
2025
2026
影响因子:

Tumor-Specific Pro-Thrombotic Gene Expression in Head and Neck Squamous Cell Carcinoma: A Multi-Cohort Transcriptomic Analysis

头颈部鳞状细胞癌中肿瘤特异性促血栓基因表达:一项多队列转录组分析

Arnold, Kiranya E; Debick, Nadia; Brognard, John; Ghosh, Auyon J

PIM kinase inhibition attenuates pro-tumoral and immunosuppressive functions of macrophages in classic Hodgkin lymphoma

PIM激酶抑制剂可减弱经典霍奇金淋巴瘤中巨噬细胞的促肿瘤和免疫抑制功能

Szydłowski, Maciej; Kurtz, Ewa; Garbicz, Filip; Maroszek, Julia; Pawlak, Michał; Ochocka, Natalia; Tabaka, Marcin; Prochorec-Sobieszek, Monika; Szumera-Ciećkiewicz, Anna; Górniak, Patryk; Szymańska-Giemza, Olga; Rymkiewicz, Grzegorz; Kołkowska-Leśniak, Agnieszka; Kukwa, Wojciech; Paszkiewicz-Kozik, Ewa; Totoń-Żurańska, Justyna; Radomska, Sylwia; Pilch, Zofia; Nowis, Dominika; Golab, Jakub; Kurlapski, Michał; Zaucha, Jan Maciej; Braczko, Alicja; Kaszkowiak, Marcin; Wołkow, Paweł; Wiktorska, Katarzyna; Brognard, John; Lichołai, Sabina; Lech-Marańda, Ewa; Juszczyński, Przemysław

CRISPR screens and quantitative proteomics reveal remodeling of the aryl hydrocarbon receptor-driven proteome through PARP7 activity.

CRISPR 筛选和定量蛋白质组学揭示了通过 PARP7 活性重塑芳烃受体驱动的蛋白质组

Gorelik Andrii, Paulo Joao A, Schroeter Christina B, Lad Melanie, Shurr Abigail, Mastrokalou Chara, Siddiqi Samrah, Suyari Osamu, Brognard John, Walter David, Matthews Jason, Palmer Timothy M, Gygi Steven P, Ahel Ivan

Targeting c-MYC and gain-of-function p53 through inhibition or degradation of the kinase LZK suppresses the growth of HNSCC tumors.

通过抑制或降解激酶 LZK 来靶向 c-MYC 和获得功能的 p53,可以抑制 HNSCC 肿瘤的生长

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, Karpińska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John

Defeating kinases that promote tumorigenesis through non-catalytic functions with PROTACs - PIM kinase as an example

利用PROTACs抑制通过非催化功能促进肿瘤发生的激酶——以PIM激酶为例

Torres-Ayuso, Pedro; Brognard, John

Selective Degradation of MLK3 by a Novel CEP1347-VHL-02 PROTAC Compound Limits the Oncogenic Potential of TNBC

新型 CEP1347-VHL-02 PROTAC 化合物选择性降解 MLK3,限制 TNBC 的致癌潜力

Kamila Karpińska, Dawid Mehlich, Venkata R Sabbasani, Michał Łomiak, Pedro Torres-Ayuso, Katarzyna Wróbel, Vi Nguyen-Phuong Truong, Remigiusz Serwa, Rolf E Swenson, John Brognard, Anna A Marusiak

PIM1 targeted degradation prevents the emergence of chemoresistance in prostate cancer

PIM1靶向降解可预防前列腺癌化疗耐药性的出现

Pedro Torres-Ayuso ,Meghri Katerji ,Dawid Mehlich ,Sophia A Lookingbill ,Venkata R Sabbasani ,Hope Liou ,Andrea L Casillas ,Shailender S Chauhan ,Remigiusz Serwa ,Maxine R Rubin ,Anna A Marusiak ,Rolf E Swenson ,Noel A Warfel ,John Brognard

TNIK inhibition sensitizes TNIK-overexpressing lung squamous cell carcinoma to radiotherapy

TNIK 抑制使 TNIK 过表达的肺鳞状细胞癌对放射治疗敏感

Triet Nguyen, Francesca Anna Carrieri, Nick Connis, Audrey Lafargue, Jinhee Chang, Aaron Chan, Amol C Shetty, Yang Song, Tung Hoang, Shreya Jagtap, Dipanwita Dutta Chowdhury, Muhammad Ajmal Khan, Kathleen L Gabrielson, Mohammad Rezaee, Pedro Torres-Ayuso, John Brognard, Christine L Hann, Phuoc T Tra

The SRC family kinase inhibitor NXP900 demonstrates potent antitumor activity in squamous cell carcinomas

SRC家族激酶抑制剂NXP900在鳞状细胞癌中表现出强大的抗肿瘤活性。

Dash, Sweta; Hanson, Sabrina; King, Ben; Nyswaner, Katherine; Foss, Kelcie; Tesi, Noelle; Harvey, Mungo J B; Navarro-Marchal, Saúl A; Woods, Allison; Poradosu, Enrique; Unciti-Broceta, Asier; Carragher, Neil O; Brognard, John

Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth.

通过抑制或降解 LZK 靶向 GOF p53 和 c-MYC 可抑制头颈部肿瘤生长

Funk Amy L, Katerji Meghri, Afifi Marwa, Nyswaner Katherine, Woodroofe Carolyn C, Edwards Zoe C, Lindberg Eric, Bergman Knickole L, Gough Nancy R, Rubin Maxine R, Karpińska Kamila, Trotter Eleanor W, Dash Sweta, Ries Amy L, James Amy, Robinson Christina M, Difilippantonio Simone, Karim Baktiar O, Chang Ting-Chia, Chen Li, Xu Xin, Doroshow James H, Ahel Ivan, Marusiak Anna A, Swenson Rolf E, Cappell Steven D, Brognard John